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PEPDIA-INT-012707

Gold

Cyclo(D-Pro-L-Leu), Diketopiperazine (pL)

80

Quality

5

Source DBs

120

Activities

19

Source refs

20

Literature

0

Patents

Integrated record

Sequence and molecular profile

PL
Indexed sequence2 aa
1PL

Length

2

Molecular weight

228.29 Da

Formula

C11H20N2O3

Structure type

Linear

Synthesis

Non-ribosomal

Chirality

-

Family

-

Gene

-

Residue composition

P
1
L
1

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

228.2881 Da

Molecular formula

C11H20N2O3

Theoretical pI

5.955

Net charge at pH 7

-0.0415

GRAVY

1.1

Instability index

5

Aromaticity

0

Topological polar surface area

78.43 Ų

cLogP

0.3539

Hydrogen-bond donors

3

Hydrogen-bond acceptors

3

Rotatable bonds

5

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

PL

HELM 2.0

validated simple linear

PEPTIDE1{P.L}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C1CCCN1)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-012707,
  title = {Cyclo(D-Pro-L-Leu), Diketopiperazine (pL)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-012707},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclo(D-Pro-L-Leu), Diketopiperazine (pL). (2026). PepDiana record PEPDIA-INT-012707. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-012707

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (120 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P012707_ACT_ahtpdb_0001Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3017ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0002Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3074ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0003Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3154ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0004Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3213ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0005Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3330ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0006Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3414ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0007Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3525ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0008Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3578ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0009Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3872ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0000Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4004ahtpdb / linked
CTPDB_P012707_ACT_ahtpdb_0010Metabolic/CardiovascularACE Inhibitor337.32 µMUnknownNot reported by source6523ahtpdb / linked
CTPDB_P012707_ACT_dbaasp_0057Antimicrobial-2370 µMBurkholderia glumae ATCC 33617Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0058Antimicrobial-290 µMBurkholderia gladioli 3704-1-FEDEARROZNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0059Antimicrobial-16 µg/mlAspergillus flavus MTCC 183Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0060Antimicrobial-50 µg/mlCandida albicans MTCC 277Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0061Antimicrobial-16 µg/mlFusarium oxysporum MTCC 284Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0062Antimicrobial-8 µg/mlRhizoctonia solani MTCC 4634Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0063Antimicrobial-4 µg/mlPenicillium expansum MTCC 2006Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0064Antimicrobial-16 µg/mlBacillus subtilis MTCC 2756Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0065Antimicrobial-32 µg/mlBacillus subtilis MTCC 2756Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0066Antimicrobial-32 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0067Antimicrobial-64 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0068Antimicrobial-250 µg/mlEscherichia coli MTCC 2622Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0069Antimicrobial-500 µg/mlEscherichia coli MTCC 2622Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0070Antimicrobial-NAPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0071Antimicrobial-20 µMHuman esophageal carcinoma Eca 109Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0072Antimicrobial-20 µMHuman cervical carcinoma HeLa S3Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0073Antimicrobial-20 µMHuman pancreatic carcinoma Panc-1Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0074Antimicrobial-64 µg/mlPhytophthora capsiciNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0075Antimicrobial-125 µg/mlPhytophthora capsiciNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0076Antimicrobial-125 µg/mlPhytophthora colocasiaeNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0077Antimicrobial-250 µg/mlPhytophthora colocasiaeNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0078Antimicrobial-500 µg/mlBotrytis cinerea MTCC 359Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0079Antimicrobial-1000 µg/mlBotrytis cinerea MTCC 359Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0080Antimicrobial-500 µg/mlColletotrichum gloeosporioides MTCC 2151Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0081Antimicrobial-500 µg/mlColletotrichum gloeosporioides MTCC 2151Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0082Antimicrobial-1939.11±0.54 µg/mlFusarium fujikuroiNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0083Antimicrobial-3490.4±0.61 µg/mlFusarium fujikuroiNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0084Antimicrobial-1450.23±0.39 µg/mlFusarium verticillioidesNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0085Antimicrobial-2601.13±0.36 µg/mlFusarium verticillioidesNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0086Antimicrobial-NAMycobacterium tuberculosis H37RvNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0087Antimicrobial-32 µg/mlEnterococcus faecium K-99-38Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0088Antimicrobial-16 µg/mlEnterococcus faecalis K-99-17Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0089Antimicrobial-8 µg/mlEnterococcus faecalis K-99-258Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0090Antimicrobial-64 µg/mlEnterococcus faecium K-01-312Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0091Antimicrobial-64 µg/mlEnterococcus faecalis K-01-511Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0092Antimicrobial-16 µg/mlEscherichia coli ATCC 10536Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0093Antimicrobial-32 µg/mlBacillus subtilis IAM 1069Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0094Antimicrobial-128 µg/mlMicrococcus luteus ATCC 4698Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0095Antimicrobial-256 µg/mlEnterococcus faecalis ATCC 10541Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0096Antimicrobial-32 µg/mlPseudomonas aeruginosa ATCC 14502Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0097Antimicrobial-64 µg/mlStaphylococcus aureus TK784Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0098Antimicrobial-256 µg/mlStaphylococcus aureus ATCC 9144Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0099Antimicrobial-32 µg/mlCandida albicansNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0100Antimicrobial-16 µg/mlCandida glabrata CMPG 681Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0101Antimicrobial-8 µg/mlCandida tropicalis CMPG 678Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0102Antimicrobial-8 µg/mlCandida tropicalis CMPG 849Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0103Antimicrobial-16 µg/mlCryptococcus neoformans ATCC 13690Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0104Antimicrobial-32 µg/mlCryptococcus neoformans CMPG 682Not reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0105Antimicrobial-13.55 µg/mlBacillus subtilisNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0106Antimicrobial-12.06 µg/mlStaphylococcus aureusNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0107Antimicrobial-12.98 µg/mlSalmonella typhimuriumNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0108Antimicrobial-10.41 µg/mlEscherichia coliNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0109Antimicrobial-1.3±0.1 µg/mlHuman glioblastoma U87-MGNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0110Antimicrobial-19.8±0.8 µg/mlHuman glioblastoma U251-MGNot reported by sourceDBAASPS_15017_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0111Antimicrobial-0.04 µg/mlVibrio anguillarum R82Not reported by sourceDBAASPS_18556_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0112Antimicrobial-20 µMHuman esophageal carcinoma Eca 109Not reported by sourceDBAASPS_18894_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0113Antimicrobial-20 µMHuman cervical carcinoma HeLa S3Not reported by sourceDBAASPS_18894_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0114Antimicrobial-20 µMHuman pancreatic carcinoma Panc-1Not reported by sourceDBAASPS_18894_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0115Antimicrobial-0.12 µg/mlVibrio anguillarum R82Not reported by sourceDBAASPS_18894_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0011Antimicrobial-16 µg/mlBacillus subtilis MTCC 2756Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0012Antimicrobial-32 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0013Antimicrobial-320 µg/mlEscherichia coli MTCC 2622Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0014Antimicrobial-NAPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0015Antimicrobial-16 µg/mlAspergillus flavus MTCC 183Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0016Antimicrobial-64 µg/mlCandida albicans MTCC 277Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0017Antimicrobial-16 µg/mlFusarium oxysporum MTCC 284Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0018Antimicrobial-8 µg/mlRhizoctonia solani MTCC 4634Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0019Antimicrobial-4 µg/mlPenicillium expansum MTCC 2006Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0020Antimicrobial-32 µg/mlStaphylococcus epidermidis MTCC 435Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0021Antimicrobial-64 µg/mlStaphylococcus epidermidis MTCC 435Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0022Antimicrobial-250 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0023Antimicrobial-500 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0024Antimicrobial-250 µg/mlProteus mirabilis MTCC 425Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0025Antimicrobial-500 µg/mlProteus mirabilis MTCC 425Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0026Antimicrobial-500 µg/mlVibrio cholerae MTCC 3905Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0027Antimicrobial-1000 µg/mlVibrio cholerae MTCC 3905Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0028Antimicrobial-32 µg/mlPhytophthora capsiciNot reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0029Antimicrobial-32 µg/mlPhytophthora capsiciNot reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0030Antimicrobial-16 µg/mlPhytophthora colocasiaeNot reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0031Antimicrobial-16 µg/mlPhytophthora colocasiaeNot reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0032Antimicrobial-500 µg/mlBotrytis cinerea MTCC 359Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0033Antimicrobial-500 µg/mlBotrytis cinerea MTCC 359Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0034Antimicrobial-1000 µg/mlColletotrichum gloeosporioides MTCC 2151Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0035Antimicrobial-1000 µg/mlColletotrichum gloeosporioides MTCC 2151Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0036Antimicrobial-8 µg/mlMycobacterium tuberculosis H37RvNot reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0037Antimicrobial-16 µg/mlMycobacterium tuberculosis H37RvNot reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0038Antimicrobial-0.13 µg/mlVibrio anguillarum R82Not reported by sourceDBAASPS_6739_chain0dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0039Antimicrobial-1 µg/mlEnterococcus faecium K-99-38Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0040Antimicrobial-0.5 µg/mlEnterococcus faecalis K-99-17Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0041Antimicrobial-0.25 µg/mlEnterococcus faecalis K-99-258Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0042Antimicrobial-2 µg/mlEnterococcus faecium K-01-312Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0043Antimicrobial-0.5 µg/mlEnterococcus faecalis K-01-511Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0044Antimicrobial-0.5 µg/mlEscherichia coli ATCC 10536Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0045Antimicrobial-1 µg/mlBacillus subtilis IAM 1069Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0046Antimicrobial-0.25 µg/mlMicrococcus luteus ATCC 4698Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0047Antimicrobial-2 µg/mlEnterococcus faecalis ATCC 10541Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0048Antimicrobial-1 µg/mlPseudomonas aeruginosa ATCC 14502Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0049Antimicrobial-0.5 µg/mlStaphylococcus aureus TK784Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0050Antimicrobial-4 µg/mlStaphylococcus aureus ATCC 9144Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0051Antimicrobial-0.25 µg/mlCandida albicansNot reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0052Antimicrobial-4 µg/mlCandida glabrata CMPG 681Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0053Antimicrobial-0.5 µg/mlCandida tropicalis CMPG 678Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0054Antimicrobial-0.5 µg/mlCandida tropicalis CMPG 849Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0055Antimicrobial-0.25 µg/mlCryptococcus neoformans ATCC 13690Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dbaasp_0056Antimicrobial-2 µg/mlCryptococcus neoformans CMPG 682Not reported by sourceDBAASPS_6747_chain1dbaasp / linked
CTPDB_P012707_ACT_dramp_0116AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceDRAMP23561dramp / linked
CTPDB_P012707_ACT_plantpepdb_0117UnknownTasteNot available in the current structured importUnknownNot reported by sourcePPepDB_2933plantpepdb / linked
CTPDB_P012707_ACT_plantpepdb_0118Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcePPepDB_2933plantpepdb / linked
CTPDB_P012707_ACT_satpdb_0119Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcesatpdb27845satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

2

Records

2

Papers

2

Positive

0

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003925View all experimental records

Provenance

Source database records (19)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

ahtpdb

4004

Raw sequence

PL

ahtpdb

6523

Raw sequence

PL

ahtpdb

3017

Raw sequence

PL

ahtpdb

3074

Raw sequence

PL

ahtpdb

3154

Raw sequence

PL

ahtpdb

3213

Raw sequence

PL

ahtpdb

3330

Raw sequence

PL

ahtpdb

3414

Raw sequence

PL

ahtpdb

3525

Raw sequence

PL

ahtpdb

3578

Raw sequence

PL

ahtpdb

3872

Raw sequence

PL

dbaasp

DBAASPS_6739_chain0

Raw sequence

pL

dbaasp

DBAASPS_6747_chain1

Raw sequence

PL

dbaasp

DBAASPS_15017_chain0

Raw sequence

PL

dbaasp

DBAASPS_18556_chain0

Raw sequence

pl

dbaasp

DBAASPS_18894_chain0

Raw sequence

Pl

dramp

DRAMP23561

Raw sequence

PL

plantpepdb

PPepDB_2933

Raw sequence

PL

satpdb

satpdb27845

Raw sequence

PL

Citation trail

Literature (20 records)

Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

Ariel Cavazos and Elvira Gonzalez de Mejia

Comprehensive Reviews in Food Science and Food Safety Volume 12, Issue 4, pages 364–380, July 20132013

Structure and activity of angiotensin I converting enzyme inhibitory peptides derived from Alaskan pollack skin.

Byun HG1, Kim SK.

J Biochem Mol Biol. 2002 Mar 31;35(2):239-43.2002PMID 12297036

Peptides with angiotensin I converting enzyme (ACE) inhibitory activity generated from porcine skeletal muscle proteins by the action of meat-borne Lactobacillus.

Castellano P1, Aristoy MC, Sentandreu MÁ, Vignolo G, Toldrá F.

J Proteomics. 2013 Aug 26;89:183-90.2013PMID 23806758

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

MOTIFS WITH POTENTIAL PHYSIOLOGICAL ACTIVITY IN FOOD PROTEINS - BIOPEP DATABASE

Iwaniak, Anna; Dziuba, Bartlomiej

Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p592009

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Isolation of proline-based cyclic dipeptides from Bacillus sp. N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties.

Kumar N, Mohandas C, Nambisan B, Kumar DR, Lankalapalli RS

World J Microbiol Biotechnol2013PMID 23065379

Isolation of proline-based cyclic dipeptides from Bacillus sp. N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties.

Kumar N, Mohandas C, Nambisan B, Kumar DR, Lankalapalli RS

World J Microbiol Biotechnol2013PMID 24622848

Isolation of proline-based cyclic dipeptides from Bacillus sp. N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties.

Kumar N, Mohandas C, Nambisan B, Kumar DR, Lankalapalli RS

World J Microbiol Biotechnol2013PMID 24122628

Isolation of proline-based cyclic dipeptides from Bacillus sp. N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties.

Kumar N, Mohandas C, Nambisan B, Kumar DR, Lankalapalli RS

World J Microbiol Biotechnol2013PMID 24047443

Isolation of proline-based cyclic dipeptides from Bacillus sp. N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties.

Kumar N, Mohandas C, Nambisan B, Kumar DR, Lankalapalli RS

World J Microbiol Biotechnol2013PMID 14575426

Cyclic dipeptides exhibit synergistic, broad spectrum antimicrobial effects and have anti-mutagenic properties.

Rhee KH

Int J Antimicrob Agents2004PMID 15519471

Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens.

Betancur LA, Forero AM, Romero-Otero A, Sepúlveda LY, Moreno-Sarmiento NC, Castellanos L, Ramos FA

J Antibiot (Tokyo)2019PMID 31243345

Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens.

Betancur LA, Forero AM, Romero-Otero A, Sepúlveda LY, Moreno-Sarmiento NC, Castellanos L, Ramos FA

J Antibiot (Tokyo)2019PMID 28223778

Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens.

Betancur LA, Forero AM, Romero-Otero A, Sepúlveda LY, Moreno-Sarmiento NC, Castellanos L, Ramos FA

J Antibiot (Tokyo)2019PMID 22747978

Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens.

Betancur LA, Forero AM, Romero-Otero A, Sepúlveda LY, Moreno-Sarmiento NC, Castellanos L, Ramos FA

J Antibiot (Tokyo)2019PMID 30270742

Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens.

Betancur LA, Forero AM, Romero-Otero A, Sepúlveda LY, Moreno-Sarmiento NC, Castellanos L, Ramos FA

J Antibiot (Tokyo)2019PMID 35142498

Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens.

Betancur LA, Forero AM, Romero-Otero A, Sepúlveda LY, Moreno-Sarmiento NC, Castellanos L, Ramos FA

J Antibiot (Tokyo)2019PMID 28512456

Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens.

Betancur LA, Forero AM, Romero-Otero A, Sepúlveda LY, Moreno-Sarmiento NC, Castellanos L, Ramos FA

J Antibiot (Tokyo)2019PMID 27806640

Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries

Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies

Cell2018PMID 29307492

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "10% Killing",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Vero cells"
    }
  ]
}
Source metadata
[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CC"
}