PepDiana
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Primary experimental recordPositive observation

PMC11277083::ACT006151

KKCH

Evidence text

Paper-level observation

Section 2.2: SPR analysis. The affinity (equilibrium dissociation constant, KD) between the KKCH peptide and the ACE2 protein was 6.24 ± 0.35 × 10^−7 M (association (Ka) = 1.54 ± 0.15 × 10^5 1/Ms; dissociation (Kd) = 9.58 ± 0.76 × 10^−2 1/s).
textConfidence: medium

Assay observation

Activity
Antiviral
Subtype
General Antiviral
Measure
other
Comparator
=
Raw observation
6.24 ± 0.35 × 10^−7 M (KD)
Normalized measurement
=0.000000624 other
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
ACE2
Assay method
Not reported by source
Sequence
KKCHFWPFPW
Standardization
ready simple
Assay conditions
"original_unit=M"

Source publication

A Natural Bioactive Peptide from Pinctada fucata Pearls Can Be Used as a Potential Inhibitor of the Interaction between SARS-CoV-2 and ACE2 against COVID-19

International Journal of Molecular Sciences · 2024

DOI 10.3390/ijms25147902 PMC11277083
Parent mention

Related peptide identities

PEPDIA-PLP-001493

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.