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Paper-scoped peptide mentionSequence reported

L-glutamine

PMC13077270::PEP000001

Source publication

Multi-omics analysis of glutamine and fish collagen peptides in alleviating post-antibiotic Streptococcus pneumoniae injury in feline lung cells.

Experimental and Therapeutic Medicine · 2026

DOI 10.3892/etm.2026.13143 PMC13077270 PMID 41988354

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 16

Sequence evidence

Reported molecular identity

Q

L-glutamine (GLU, purity >99%) ... sourced from Shanghai Macklin Biochemical Co., Ltd.

Resolved peptide links

PEPDIA-PLP-002269

Experimental observations

Records linked to this mention

ToxicityCytotoxicPositive observation

CCK-8 assays demonstrated that GLU (1.25-20 mM) ... had no adverse effects on FCA-L2 cell viability.

Mention PMC13077270::PEP000001PMC13077270text

Measure: cell_viability
Value: no adverse effects
Target: FCA-L2
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

higher concentrations (40-80 mM GLU ...) demonstrated slight promotive effects on cell growth, confirming their safety.

Mention PMC13077270::PEP000001PMC13077270text

Measure: cell_viability
Value: slight promotive effects
Target: FCA-L2
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

treatment with GLU reduced LDH release to 225.86±17.42% (40 mM)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 225.86±17.42% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

treatment with GLU reduced LDH release to ... 228.05±15.29% (80 mM)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 228.05±15.29% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

IL-1β decreased from 96.96±4.66 pg/ml (SP) to 75.61±7.01 pg/ml (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 75.61±7.01 pg/ml
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

TNF-α decreased from 19.88±1.85 pg/ml to 16.72±1.07 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 16.72±1.07 pg/ml
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

IL-8 decreased from 60.02±4.47 pg/ml to 55.67±2.80 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 55.67±2.80 pg/ml
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

OtherAntibacterialPositive observation

Claudin increased from 59.76 pg/mg (SP) to 74.22 (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 74.22 pg/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

OtherAntibacterialPositive observation

ZO-1 increased from 395.17 to 484.65 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 484.65 ng/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

OtherAntibacterialPositive observation

occludin increased from 84.39 to 99.20 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 99.20 ng/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

OtherAntibacterialPositive observation

E-cadherin, its expression was significantly restored by GLU treatment, increasing from 424.23 ng/mg in the SP group to 465.27 ng/mg.

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 465.27 ng/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

treatment with 40 mM GLU ... restored cell morphology and increased the relative density to 85.89 ...%

Mention PMC13077270::PEP000001PMC13077270text

Measure: cell_viability
Value: 85.89% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

GLU ... treatment effectively mitigated this effect, reducing the intensity to 314.27 ...%

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 314.27% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

SP infection significantly elevated MDA levels ... These alterations were significantly reversed by both GLU ... treatment.

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: significantly reversed
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

SP infection significantly ... reduced SOD ... activities ... These alterations were significantly reversed by both GLU ... treatment.

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: significantly reversed
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

SP infection significantly ... reduced ... GPX activities ... These alterations were significantly reversed by both GLU ... treatment.

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: significantly reversed
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.