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Paper-scoped peptide mentionSequence reported

C-CR5

PMC12839123::PEP000002

Source publication

Comparison of In Vitro Multiple Physiological Activities of Cys–Tyr–Gly–Ser–Arg (CYGSR) Linear and Cyclic Peptides and Analysis Based on Molecular Docking

Biomolecules · 2026

Sequence status
reported
Standardization
Sequence ready
Source location
unknown
Activity records
11

Sequence evidence

Reported molecular identity

CYGSR

CYGSR

Resolved peptide links

Experimental observations

Records linked to this mention

AntioxidantPositive observation
Record detail

the IC50 of C-CR5 was found to be 16.92 ± 0.47 μg/mL (29.86 ± 0.83 μM). Figure 3 caption: IC50 = 16.92 ± 0.47 μg/mL; (29.86 ± 0.83 μM), n = 3.

Measure
other
Value
16.92 ± 0.47 μg/mL (29.86 ± 0.83 μM)
Target
Not reported by source
Assay
Not reported by source
Source publication
AntioxidantAntibacterialPositive observation
Record detail

C-CR5 showed very high activity from 73% to 83% under the same concentration condition [25–400 μg/mL].

Measure
percent_inhibition
Value
73% (at 25 μg/mL)
Target
Not reported by source
Assay
Not reported by source
Source publication
AntioxidantAntibacterialPositive observation
Record detail

C-CR5 showed very high activity from 73% to 83% under the same concentration condition [25–400 μg/mL].

Measure
percent_inhibition
Value
83% (at 400 μg/mL)
Target
Not reported by source
Assay
Not reported by source
Source publication
AntioxidantTyrosinase InhibitorPositive observation
Record detail

the IC50 of C-CR5 was identified as 104.2 ± 5.3 μg/mL (184.0 ± 9.4 μM). Figure 4 caption: IC50 = 104.2 ± 5.3 μg/mL; (184.0 ± 9.4 μM), n = 3.

Measure
other
Value
104.2 ± 5.3 μg/mL (184.0 ± 9.4 μM)
Target
mushroom tyrosinase
Assay
Not reported by source
Source publication
AntioxidantTyrosinase InhibitorPositive observation
Record detail

C-CR5 showed a rapid increase from 30.91% to 97.79% in the same concentration section [50–800 μg/mL].

Measure
percent_inhibition
Value
30.91% (at 50 μg/mL)
Target
mushroom tyrosinase
Assay
Not reported by source
Source publication
AntioxidantTyrosinase InhibitorPositive observation
Record detail

C-CR5 showed a rapid increase from 30.91% to 97.79% in the same concentration section [50–800 μg/mL].

Measure
percent_inhibition
Value
97.79% (at 800 μg/mL)
Target
mushroom tyrosinase
Assay
Not reported by source
Source publication
AntioxidantMMP-1 InhibitorPositive observation
Record detail

the expression level of C-CR5 decreased sharply from 200 μg/mL to 63.31%.

Measure
percent_inhibition
Value
63.31% expression (36.69% inhibition) at 200 μg/mL
Target
CCD-986sk
Assay
Not reported by source
Source publication
AntioxidantMMP-1 InhibitorPositive observation
Record detail

decreased to 7.78% at 400 μg/mL, showing almost complete inhibitory effects.

Measure
percent_inhibition
Value
7.78% expression (92.22% inhibition) at 400 μg/mL
Target
CCD-986sk
Assay
Not reported by source
Source publication
ToxicityCytotoxicNegative / threshold
Record detail

As a result of treating the RAW 264.7 macrophages with L-CR5 and C-CR5 at a concentration of 6.25–400 μg/mL, cell viability was maintained at 95% or more in all treatment groups.

Measure
cell_viability
Value
≥95%
Target
RAW 264.7
Assay
Not reported by source
Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.