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Paper-scoped peptide mentionSequence reported

P15

PMC12655529::PEP000015

Source publication

Serendipitous Hinge Modulation Hypothetically Reprograms Caerin 1.1-LC Antibacterial Mechanism and Gram-Negative Selectivity

Pharmaceutics · 2025

DOI 10.3390/pharmaceutics17111500 PMC12655529 PMID 41304836

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 33

Sequence evidence

Reported molecular identity

GLLSVLKSLKKIVPHVVPKIAEKLNH

GLLSVLKSLKKIVPHvvPKIAEKL-NH2

Resolved peptide links

PEPDIA-PLP-001025

Experimental observations

Records linked to this mention

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 2 µM against E. coli ATCC 8739

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 2.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 4 µM against E. coli ATCC 8739

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 4 µM against E. coli ATCC BAA-2340

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 8 µM against E. coli NCTC 13846

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 8.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 8 µM against E. coli NCTC 13846

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 8.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 64 µM against K. pneumoniae ATCC 43816

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 64.0 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 128 µM against K. pneumoniae ATCC 43816

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 128.0 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 16 µM against K. pneumoniae ATCC BAA-2342

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 16.0 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 32 µM against K. pneumoniae ATCC BAA-2342

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 32.0 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against P. aeruginosa ATCC 9027

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 4 µM against P. aeruginosa ATCC 9027

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 32 µM against A. baumannii ATCC BAA-747

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 32.0 µM
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 128 µM against A. baumannii ATCC BAA-747

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 128.0 µM
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 128 µM against S. aureus ATCC 6538

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 128.0 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 128 µM against S. aureus ATCC 6538

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 128.0 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Negative / threshold

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC >128 µM against E. faecalis NCTC 12697

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: >128 µM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 64 µM against MRSA NCTC 12493

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 64.0 µM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 64 µM against MRSA NCTC 12493

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 64.0 µM
Target: MRSA
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Table 4: Caerin 1.1-LC 7.11.19K.V(D)V(D) HC10 256 µM

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 256.0 µM
Target: erythrocytes
Assay: Not reported by source

Source publication

ToxicityCytotoxicNegative / threshold

Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against MRC-5

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: NI
Target: MRC-5
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 129.6 µM against HEK 293

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 129.6 µM
Target: HEK 293
Assay: Not reported by source

Source publication

ToxicityCytotoxicNegative / threshold

Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against HMEC-1

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: NI
Target: HMEC-1
Assay: Not reported by source

Source publication

ToxicityCytotoxicNegative / threshold

Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against HaCaT

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: NI
Target: HaCaT
Assay: Not reported by source

Source publication

ToxicityCytotoxicNegative / threshold

Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against RAW 264.7

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: NI
Target: RAW 264.7
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 16 µM against E. coli ATCC BAA-2340 in Na+

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 16.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 in K+

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 in NH4+

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 32 µM against E. coli ATCC BAA-2340 in Mg2+

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 32.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 128 µM against E. coli ATCC BAA-2340 in Ca2+

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 128.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 in Fe3+

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 16 µM against E. coli ATCC BAA-2340 in FBS

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 16.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 Control

Mention PMC12655529::PEP000015PMC12655529table

Measure: unknown
Value: 4.0 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.