ProForma 2.0
validated simple linear
GLLSVLKSLKKIVPHVVPKIAEKLNH
P15
Aliases: P15, P6
Normalized sequence
GLLSVLKSLKKIVPHVVPKIAEKLNH
26 amino acids
Release PepDiana-V1-20260620
62
Activity records
1
Source papers
57
Positive
5
Negative / threshold
Versioned scientific descriptors
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Molecular weight
2861.5134 Da
Molecular formula
C134H234N36O32
Theoretical pI
10.1769
Net charge at pH 7
3.9323
GRAVY
0.3269
Instability index
4.8385
Aromaticity
0
Topological polar surface area
1081.55 Ų
cLogP
-5.5699
Hydrogen-bond donors
36
Hydrogen-bond acceptors
38
Rotatable bonds
98
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
ProForma 2.0
validated simple linear
GLLSVLKSLKKIVPHVVPKIAEKLNH
HELM 2.0
validated simple linear
PEPTIDE1{G.L.L.S.V.L.K.S.L.K.K.I.V.P.H.V.V.P.K.I.A.E.K.L.N.H}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CN)C(C)C)C(C)CC)C(C)C)C(C)C)C(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)O
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Paper-level observations
Table 3: Caerin 1.1-LC 7.11.19K MIC 2 µM against E. coli ATCC 8739
Table 3: Caerin 1.1-LC 7.11.19K MBC 2 µM against E. coli ATCC 8739
Table 3: Caerin 1.1-LC 7.11.19K MIC 2 µM against E. coli ATCC BAA-2340
Table 3: Caerin 1.1-LC 7.11.19K MBC 2 µM against E. coli ATCC BAA-2340
Table 3: Caerin 1.1-LC 7.11.19K MIC 4 µM against E. coli NCTC 13846
Table 3: Caerin 1.1-LC 7.11.19K MBC 4 µM against E. coli NCTC 13846
Table 3: Caerin 1.1-LC 7.11.19K MIC 4 µM against K. pneumoniae ATCC 43816
Table 3: Caerin 1.1-LC 7.11.19K MBC 4 µM against K. pneumoniae ATCC 43816
Table 3: Caerin 1.1-LC 7.11.19K MIC 4 µM against K. pneumoniae ATCC BAA-2342
Table 3: Caerin 1.1-LC 7.11.19K MBC 4 µM against K. pneumoniae ATCC BAA-2342
Table 3: Caerin 1.1-LC 7.11.19K MIC 4 µM against P. aeruginosa ATCC 9027
Table 3: Caerin 1.1-LC 7.11.19K MBC 4 µM against P. aeruginosa ATCC 9027
Table 3: Caerin 1.1-LC 7.11.19K MIC 4 µM against A. baumannii ATCC BAA-747
Table 3: Caerin 1.1-LC 7.11.19K MBC 8 µM against A. baumannii ATCC BAA-747
Table 3: Caerin 1.1-LC 7.11.19K MIC 4 µM against S. aureus ATCC 6538
Table 3: Caerin 1.1-LC 7.11.19K MBC 4 µM against S. aureus ATCC 6538
Table 3: Caerin 1.1-LC 7.11.19K MIC 128 µM against E. faecalis NCTC 12697
Table 3: Caerin 1.1-LC 7.11.19K MBC 128 µM against E. faecalis NCTC 12697
Table 3: Caerin 1.1-LC 7.11.19K MIC 8 µM against MRSA NCTC 12493
Table 3: Caerin 1.1-LC 7.11.19K MBC 8 µM against MRSA NCTC 12493
Table 6: Caerin 1.1-LC 7.11.19K MIC 2 µM against E. coli ATCC BAA-2340 in Na+
Table 6: Caerin 1.1-LC 7.11.19K MIC 2 µM against E. coli ATCC BAA-2340 in K+
Table 6: Caerin 1.1-LC 7.11.19K MIC 2 µM against E. coli ATCC BAA-2340 in NH4+
Table 6: Caerin 1.1-LC 7.11.19K MIC 4 µM against E. coli ATCC BAA-2340 in Mg2+
Table 6: Caerin 1.1-LC 7.11.19K MIC 64 µM against E. coli ATCC BAA-2340 in Ca2+
Table 6: Caerin 1.1-LC 7.11.19K MIC 2 µM against E. coli ATCC BAA-2340 in Fe3+
Table 6: Caerin 1.1-LC 7.11.19K MIC 16 µM against E. coli ATCC BAA-2340 in FBS
Table 6: Caerin 1.1-LC 7.11.19K MIC 2 µM against E. coli ATCC BAA-2340 Control
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 2 µM against E. coli ATCC 8739
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 4 µM against E. coli ATCC 8739
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 4 µM against E. coli ATCC BAA-2340
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 8 µM against E. coli NCTC 13846
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 8 µM against E. coli NCTC 13846
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 64 µM against K. pneumoniae ATCC 43816
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 128 µM against K. pneumoniae ATCC 43816
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 16 µM against K. pneumoniae ATCC BAA-2342
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 32 µM against K. pneumoniae ATCC BAA-2342
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against P. aeruginosa ATCC 9027
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 4 µM against P. aeruginosa ATCC 9027
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 32 µM against A. baumannii ATCC BAA-747
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 128 µM against A. baumannii ATCC BAA-747
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 128 µM against S. aureus ATCC 6538
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 128 µM against S. aureus ATCC 6538
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC >128 µM against E. faecalis NCTC 12697
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 64 µM against MRSA NCTC 12493
Table 3: Caerin 1.1-LC 7.11.19K.V(D)V(D) MBC 64 µM against MRSA NCTC 12493
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 16 µM against E. coli ATCC BAA-2340 in Na+
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 in K+
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 in NH4+
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 32 µM against E. coli ATCC BAA-2340 in Mg2+
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 128 µM against E. coli ATCC BAA-2340 in Ca2+
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 in Fe3+
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 16 µM against E. coli ATCC BAA-2340 in FBS
Table 6: Caerin 1.1-LC 7.11.19K.V(D)V(D) MIC 4 µM against E. coli ATCC BAA-2340 Control
Table 4: Caerin 1.1-LC 7.11.19K HC10 46.5 µM
Table 4: Caerin 1.1-LC 7.11.19K.V(D)V(D) HC10 256 µM
Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against MRC-5
Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 129.6 µM against HEK 293
Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against HMEC-1
Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against HaCaT
Table 5: Caerin 1.1-LC 7.11.19K.V(D)V(D) IC50 NI against RAW 264.7
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-001025, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00