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Primary-literature peptidehigh evidence

PEPDIA-PLP-001025

P15

Aliases: P15, P6

Normalized sequence

GLLSVLKSLKKIVPHVVPKIAEKLNH

26 amino acids

Release PepDiana-V1-20260620

62

Activity records

1

Source papers

57

Positive

5

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

2861.5134 Da

Molecular formula

C134H234N36O32

Theoretical pI

10.1769

Net charge at pH 7

3.9323

GRAVY

0.3269

Instability index

4.8385

Aromaticity

0

Topological polar surface area

1081.55 Ų

cLogP

-5.5699

Hydrogen-bond donors

36

Hydrogen-bond acceptors

38

Rotatable bonds

98

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

GLLSVLKSLKKIVPHVVPKIAEKLNH

HELM 2.0

validated simple linear

PEPTIDE1{G.L.L.S.V.L.K.S.L.K.K.I.V.P.H.V.V.P.K.I.A.E.K.L.N.H}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CN)C(C)C)C(C)CC)C(C)C)C(C)C)C(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O

Paper-level observations

Experimental evidence grouped by activity

Antimicrobial 55 records

PMC12655529

55 observations
Toxicity 7 records

PMC12655529

7 observations

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-001025, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00