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Paper-scoped peptide mentionSequence reported

mAc-AMP2

PMC12655060::PEP000001

Source publication

Modified Hevein-like Peptide from Amaranthus caudatus as a Promising Agent Against Pathogenic Candida Species

Pharmaceutics · 2025

DOI 10.3390/pharmaceutics17111406 PMC12655060 PMID 41304745

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 53

Sequence evidence

Reported molecular identity

VGECVRGRCPSGACCSQWGYCGKGPKYCGR

VGECVRGRCPSGACC SQWGYCGKGPKYCGR

Resolved peptide links

PEPDIA-PLP-002970

Experimental observations

Records linked to this mention

AntimicrobialAntifungalPositive observation

Table 1: C. albicans ATCC 18804 MIC 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans ATCC 18804 MIC50 0.19–0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.19–0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans ATCC 18804 MFC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 0.78 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans ATCC 10231 MIC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.78 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans ATCC 10231 MIC50 0.19–0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.19–0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 1: C. albicans ATCC 10231 MFC >6.25 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: >6.25 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 1: C. albicans ATCC 10231 BIC50 25–50 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 25–50 (BIC50)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 1: C. albicans ATCC 10231 BIC 50 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 50 (BIC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans 8.2 MIC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.78 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans 8.2 MIC50 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 1: C. albicans 8.2 MFC >6.25 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: >6.25 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 1: C. albicans 8.2 BIC50 6.25–12.5 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 6.25–12.5 (BIC50)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 1: C. albicans 8.2 BIC 12.5 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 12.5 (BIC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans 9.1 MIC 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans 9.1 MIC50 0.19–0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.19–0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. albicans 9.1 MFC 6.25 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 6.25 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 1: C. albicans 9.1 BIC50 6.25–12.5 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 6.25–12.5 (BIC50)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 1: C. albicans 9.1 BIC 50 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 50 (BIC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. tropicalis v13a4/2 MIC 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida tropicalis
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. tropicalis v13a4/2 MIC50 0.09–0.19 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.09–0.19 µM
Target: Candida tropicalis
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 1: C. tropicalis v13a4/2 MFC >12.5 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: >12.5 (MFC)
Target: Candida tropicalis
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. krusei 225/2 MIC 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida krusei
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. krusei 225/2 MIC50 0.09–0.19 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.09–0.19 µM
Target: Candida krusei
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 1: C. krusei 225/2 MFC >12.5 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: >12.5 (MFC)
Target: Candida krusei
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. glabrata 252/2 MIC 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida glabrata
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 1: C. glabrata 252/2 MIC50 0.09–0.19 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.09–0.19 µM
Target: Candida glabrata
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 1: C. glabrata 252/2 MFC >12.5 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: >12.5 (MFC)
Target: Candida glabrata
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 150 mM NaCl MIC 6.25 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 6.25 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 150 mM NaCl MFC 6.25 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 6.25 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 1.25 mM CaCl2 MIC 3.13 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 3.13 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 1.25 mM CaCl2 MFC 6.25 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 6.25 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 1.25 mM MgCl2 MIC 1.56 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 1.56 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 1.25 mM MgCl2 MFC 3.13 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 3.13 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 10% FBS MIC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.78 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: 10% FBS MFC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 0.78 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: RPMI-1640 MIC 50 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 50 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 2: RPMI-1640 MFC >50 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: >50 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: pH 5.0 MIC 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: pH 5.0 MFC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 0.78 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: pH 7.0 MIC 0.39 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.39 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 2: pH 7.0 MFC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 0.78 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 4: mAc-AMP2 with 3.25 µM GSH MIC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.78 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 4: mAc-AMP2 with 3.25 µM GSH MFC 1.56 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 1.56 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 4: mAc-AMP2 after DTT MIC >12.5 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: >12.5 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 4: mAc-AMP2 after 99°C MIC 0.78 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: MIC
Value: 0.78 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 4: mAc-AMP2 after 99°C MFC 3.13 µM.

Mention PMC12655060::PEP000001PMC12655060table

Measure: other
Value: 3.13 (MFC)
Target: Candida albicans
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Section 3.7: mAc-AMP2 did not cause lysis of erythrocytes after incubation for 2 h even at the concentration of 100 µM.

Mention PMC12655060::PEP000001PMC12655060text

Measure: hemolysis
Value: ~0%
Target: Homo sapiens
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Section 3.7: cell viability of approximately 100% was observed even at the peptide concentration of 100 µM in the case of the Caco-2 cell monolayer.

Mention PMC12655060::PEP000001PMC12655060text

Measure: cell_viability
Value: ~100%
Target: Caco-2
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Section 3.7: The absence of cytotoxic effects was also shown for PBMCs at a mAc-AMP2 concentration of 25 µM.

Mention PMC12655060::PEP000001PMC12655060text

Measure: cell_viability
Value: ~100%
Target: PBMC
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Section 3.3: mAc-AMP2 inhibited adhesion of the clinical isolate 8.2 by 42% at concentration of 1.56 µM.

Mention PMC12655060::PEP000001PMC12655060text

Measure: percent_inhibition
Value: 42%
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Section 3.3: mAc-AMP2 inhibited adhesion of the clinical isolate 8.2 by 45% at concentration of 3.13 µM.

Mention PMC12655060::PEP000001PMC12655060text

Measure: percent_inhibition
Value: 45%
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Section 3.3: mAc-AMP2 inhibited adhesion of the clinical isolate 8.2 by 81% at concentration of 6.25 µM.

Mention PMC12655060::PEP000001PMC12655060text

Measure: percent_inhibition
Value: 81%
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Section 3.3: mAc-AMP2 inhibited adhesion of the clinical isolate 8.2 by 96% at concentration of 12.5 µM.

Mention PMC12655060::PEP000001PMC12655060text

Measure: percent_inhibition
Value: 96%
Target: Candida albicans
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.