Back to Evidence

Paper-scoped peptide mentionSequence reported

peptide_7

PMC12216437::PEP000008

Source publication

Enhancing the selectivity and conditional sensitivity of an antimicrobial peptide through cleavage simulations and homoarginine incorporation to combat drug-resistant bacteria.

Scientific Reports · 2025

DOI 10.1038/s41598-025-06522-8 PMC12216437 PMID 40594393

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 55

Sequence evidence

Reported molecular identity

GFSSIFHRGVAHRFASHRGLGHR

Table 1: [hArg7,11,15,19]-des-(Asp20-Cys37)-E2P, 7, sequence GFSSIFhRGVAhRFAShRGLGhR-NH2

Resolved peptide links

PEPDIA-PLP-000887

Experimental observations

Records linked to this mention

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against S. aureus ATCC 6538 = 4/8 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against S. aureus ATCC 6538 = 4/8 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 8 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against MRSA NCTC 12493 = 32/32 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 32 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against MRSA NCTC 12493 = 32/32 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 32 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. faecalis NCTC 12697 = 32/64 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 32 µM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. faecalis NCTC 12697 = 32/64 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 64 µM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli ATCC 8739 = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli ATCC 8739 = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli NCTC 13846 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli NCTC 13846 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli ATCC 2340 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli ATCC 2340 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli ATCC 2469 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against E. coli ATCC 2469 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against K. pneumoniae ATCC 43816 = 8/8 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 8 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against K. pneumoniae ATCC 43816 = 8/8 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 8 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against A. baumannii ATCC BAA 747 = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against A. baumannii ATCC BAA 747 = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against P. aeruginosa ATCC 27853 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: peptide 7 MIC/MBC against P. aeruginosa ATCC 27853 = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in K+ = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in K+ = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Ca2+ = 64/64 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 64 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Ca2+ = 64/64 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 64 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Na+ = 8/16 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Na+ = 8/16 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 16 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Mg2+ = 8/8 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Mg2+ = 8/8 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Zn2+ = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Zn2+ = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Fe3+ = 2/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Fe3+ = 2/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in NH4+ = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in NH4+ = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 10% serum = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 10% serum = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 20% serum = 8/16 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 20% serum = 8/16 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 16 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

ToxicityHemolyticNegative / threshold

Table 5: peptide 7 MHC = >128 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: HD50
Value: >128 µM
Target: Equus caballus
Assay: Not reported by source

Source publication

ToxicityCytotoxicNegative / threshold

Table 5: peptide 7 IC50 = >100 µM against HEK-293

Mention PMC12216437::PEP000008PMC12216437table

Measure: other
Value: >100 µM
Target: HEK-293
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 at 80 °C = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 at 80 °C = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.25 mg/mL trypsin = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.25 mg/mL trypsin = 2/2 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 2 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.5 mg/mL trypsin = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.5 mg/mL trypsin = 4/4 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 1 mg/mL trypsin = 16/16 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MIC
Value: 16 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 1 mg/mL trypsin = 16/16 µM

Mention PMC12216437::PEP000008PMC12216437table

Measure: MBC
Value: 16 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Fig. 8 and text: peptide 7 at 4×MIC increased survival rate from 60 to 90% for E. coli ATCC 2340 infected larvae

Mention PMC12216437::PEP000008PMC12216437text

Measure: survival_rate
Value: 90%
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Fig. 8 and text: peptide 7 increased survival rate from 30 to 55% for E. coli NCTC 13846 infected larvae

Mention PMC12216437::PEP000008PMC12216437text

Measure: survival_rate
Value: 55%
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Fig. 8 and text: peptide 7 improved survival rate to 30–45% for E. coli ATCC 2469 infected larvae

Mention PMC12216437::PEP000008PMC12216437text

Measure: survival_rate
Value: 30–45%
Target: Escherichia coli
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.