ProForma 2.0
validated simple linear
GFSSIFHRGVAHRFASHRGLGHR
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000887
peptide_7
Aliases: peptide_7
Normalized sequence
GFSSIFHRGVAHRFASHRGLGHR
23 amino acids
Release PepDiana-V1-20260620
55
Activity records
1
Source papers
53
Positive
2
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
2589.8758 Da
Molecular formula
C115H173N43O27
Theoretical pI
12
Net charge at pH 7
4.1088
GRAVY
-0.4478
Instability index
6.8652
Aromaticity
0.1304
Topological polar surface area
1126.53 Ų
cLogP
-13.0012
Hydrogen-bond donors
43
Hydrogen-bond acceptors
35
Rotatable bonds
83
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{G.F.S.S.I.F.H.R.G.V.A.H.R.F.A.S.H.R.G.L.G.H.R}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)CN)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(C(=O)NC(C)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCNC(=N)N)C(=O)O)C(C)C
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 53 records
PMC12216437
53 observationsAntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against S. aureus ATCC 6538 = 4/8 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against S. aureus ATCC 6538 = 4/8 µM
- Measure
- MBC
- Value
- 8 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against MRSA NCTC 12493 = 32/32 µM
- Measure
- MIC
- Value
- 32 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against MRSA NCTC 12493 = 32/32 µM
- Measure
- MBC
- Value
- 32 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. faecalis NCTC 12697 = 32/64 µM
- Measure
- MIC
- Value
- 32 µM
- Target
- Enterococcus faecalis
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. faecalis NCTC 12697 = 32/64 µM
- Measure
- MBC
- Value
- 64 µM
- Target
- Enterococcus faecalis
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli ATCC 8739 = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli ATCC 8739 = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli NCTC 13846 = 4/4 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli NCTC 13846 = 4/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli ATCC 2340 = 4/4 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli ATCC 2340 = 4/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli ATCC 2469 = 4/4 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against E. coli ATCC 2469 = 4/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against K. pneumoniae ATCC 43816 = 8/8 µM
- Measure
- MIC
- Value
- 8 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against K. pneumoniae ATCC 43816 = 8/8 µM
- Measure
- MBC
- Value
- 8 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against A. baumannii ATCC BAA 747 = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against A. baumannii ATCC BAA 747 = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against P. aeruginosa ATCC 27853 = 4/4 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 3: peptide 7 MIC/MBC against P. aeruginosa ATCC 27853 = 4/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in K+ = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in K+ = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Ca2+ = 64/64 µM
- Measure
- MIC
- Value
- 64 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Ca2+ = 64/64 µM
- Measure
- MBC
- Value
- 64 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Na+ = 8/16 µM
- Measure
- MIC
- Value
- 8 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Na+ = 8/16 µM
- Measure
- MBC
- Value
- 16 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Mg2+ = 8/8 µM
- Measure
- MIC
- Value
- 8 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Mg2+ = 8/8 µM
- Measure
- MBC
- Value
- 8 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Zn2+ = 4/4 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Zn2+ = 4/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Fe3+ = 2/4 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in Fe3+ = 2/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in NH4+ = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in NH4+ = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 10% serum = 4/4 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 10% serum = 4/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 20% serum = 8/16 µM
- Measure
- MIC
- Value
- 8 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: peptide 7 MIC/MBC against E. coli ATCC 8739 in 20% serum = 8/16 µM
- Measure
- MBC
- Value
- 16 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 Control = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 at 80 °C = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 at 80 °C = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.25 mg/mL trypsin = 2/2 µM
- Measure
- MIC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.25 mg/mL trypsin = 2/2 µM
- Measure
- MBC
- Value
- 2 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.5 mg/mL trypsin = 4/4 µM
- Measure
- MIC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 0.5 mg/mL trypsin = 4/4 µM
- Measure
- MBC
- Value
- 4 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 1 mg/mL trypsin = 16/16 µM
- Measure
- MIC
- Value
- 16 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 6: peptide 7 MIC/MBC against E. coli ATCC 8739 with 1 mg/mL trypsin = 16/16 µM
- Measure
- MBC
- Value
- 16 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Fig. 8 and text: peptide 7 at 4×MIC increased survival rate from 60 to 90% for E. coli ATCC 2340 infected larvae
- Measure
- survival_rate
- Value
- 90%
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Fig. 8 and text: peptide 7 increased survival rate from 30 to 55% for E. coli NCTC 13846 infected larvae
- Measure
- survival_rate
- Value
- 55%
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Fig. 8 and text: peptide 7 improved survival rate to 30–45% for E. coli ATCC 2469 infected larvae
- Measure
- survival_rate
- Value
- 30–45%
- Target
- Escherichia coli
- Assay
- Not reported by source
Toxicity 2 records
PMC12216437
2 observationsToxicityHemolyticNegative / threshold
Record detail Table 5: peptide 7 MHC = >128 µM
- Measure
- HD50
- Value
- >128 µM
- Target
- Equus caballus
- Assay
- Not reported by source
ToxicityCytotoxicNegative / threshold
Record detail Table 5: peptide 7 IC50 = >100 µM against HEK-293
- Measure
- other
- Value
- >100 µM
- Target
- HEK-293
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000887, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00