Back to Evidence
Paper-scoped peptide mentionSequence reported

PEP1

PMC11678430::PEP000001

Source publication

Assessing Cytotoxicity, Proteolytic Stability, and Selectivity of Antimicrobial Peptides: Implications for Orthopedic Applications.

International Journal of Molecular Sciences · 2024

Sequence status
reported
Standardization
Sequence ready
Source location
unknown
Activity records
28

Sequence evidence

Reported molecular identity

KKVVFKVKFK

The synthetic peptides KSL (aminoacidic sequence: KKVVFKVKFK)...

Resolved peptide links

Experimental observations

Records linked to this mention

ToxicityCytotoxicPositive observation
Record detail

In the presence of FBS, IC50 values fell in a rather restricted range... with MG63 cells, the cytotoxicity variation in the presence and absence of FBS was marginal (with an IC50 value of 128.2 vs. 111.1 μg/mL, respectively).

Measure
other
Value
128.2 μg/mL
Target
MG63
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

In the absence of FBS, IC50 values always decreased... with MG63 cells, the cytotoxicity variation in the presence and absence of FBS was marginal (with an IC50 value of 128.2 vs. 111.1 μg/mL, respectively).

Measure
other
Value
111.1 μg/mL
Target
MG63
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

Table 2: S.I. values based on IC50 values of hMSCs cultured without FBS. KSL against SE = 34.2 (30.7–37.6).

Measure
SI
Value
34.2 (30.7–37.6)
Target
Staphylococcus epidermidis
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

Table 2: S.I. values based on IC50 values of hMSCs cultured without FBS. KSL against SE = 136.4 (122.6–150.2).

Measure
SI
Value
136.4 (122.6–150.2)
Target
Staphylococcus epidermidis
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

Table 2: S.I. values based on IC50 values of hMSCs cultured with FBS. KSL against SE = 211.6 (199.0–224.3).

Measure
SI
Value
211.6 (199.0–224.3)
Target
Staphylococcus epidermidis
Assay
Not reported by source
Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.