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Primary-literature peptidehigh evidence

PEPDIA-PLP-003762

PEP1

Aliases: PEP1

Normalized sequence

KKVVFKVKFK

10 amino acids

Release PepDiana-V1-20260620

28

Activity records

1

Source papers

28

Positive

0

Negative / threshold

Cross-layer links

Related Integrated records

Versioned scientific descriptors

Physicochemical properties and standard representations

not calculated

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

Not calculated

Molecular formula

Not calculated

Theoretical pI

Not calculated

Net charge at pH 7

Not calculated

GRAVY

Not calculated

Instability index

Not calculated

Aromaticity

Not calculated

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: Not recorded

Tool: Not recorded

Calculated: Not recorded

Sequence representations

representations-20260620

ProForma 2.0

Not calculated for this record

HELM 2.0

Not calculated for this record

Canonical SMILES

Not calculated for this record

Isomeric SMILES

Not calculated for this record

Paper-level observations

Experimental evidence grouped by activity

Toxicity 20 records

PMC11678430

20 observations
ToxicityCytotoxicPositive observation
Record detail

In the presence of FBS, IC50 values fell in a rather restricted range... with MG63 cells, the cytotoxicity variation in the presence and absence of FBS was marginal (with an IC50 value of 128.2 vs. 111.1 μg/mL, respectively).

Measure
other
Value
128.2 μg/mL
Target
MG63
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

In the absence of FBS, IC50 values always decreased... with MG63 cells, the cytotoxicity variation in the presence and absence of FBS was marginal (with an IC50 value of 128.2 vs. 111.1 μg/mL, respectively).

Measure
other
Value
111.1 μg/mL
Target
MG63
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

Table 2: S.I. values based on IC50 values of hMSCs cultured without FBS. KSL against SE = 34.2 (30.7–37.6).

Measure
SI
Value
34.2 (30.7–37.6)
Target
Staphylococcus epidermidis
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

Table 2: S.I. values based on IC50 values of hMSCs cultured without FBS. KSL against SE = 136.4 (122.6–150.2).

Measure
SI
Value
136.4 (122.6–150.2)
Target
Staphylococcus epidermidis
Assay
Not reported by source
Source publication
ToxicityCytotoxicPositive observation
Record detail

Table 2: S.I. values based on IC50 values of hMSCs cultured with FBS. KSL against SE = 211.6 (199.0–224.3).

Measure
SI
Value
211.6 (199.0–224.3)
Target
Staphylococcus epidermidis
Assay
Not reported by source
Source publication
Antimicrobial 8 records

PMC11678430

8 observations

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-003762, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00