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Paper-scoped peptide mentionSequence reported

temporin-SHf

PMC10847208::PEP000001

Source publication

Antimicrobial and antitumor properties of anuran peptide temporin-SHf induce apoptosis in A549 lung cancer cells.

Amino Acids · 2024

DOI 10.1007/s00726-023-03373-3 PMC10847208 PMID 38319435

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 25

Sequence evidence

Reported molecular identity

FFFLSRIF

FFFLSRIF

Resolved peptide links

PEPDIA-PLP-003483 CTPDB_P065994

Experimental observations

Records linked to this mention

AntimicrobialAnti-Gram-Positive observation

Table 2: Escherichia coli (ATCC 25922) MIC 24.74 ± 0.968 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: MIC
Value: 24.74 ± 0.968 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 2: Pseudomonas aeruginosa (ATCC 15442) MIC 108.32 ± 1.758 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: MIC
Value: 108.32 ± 1.758 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 2: Klebsiella pneumonia (ATCC 13883) MIC 42.56 ± 1.455 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: MIC
Value: 42.56 ± 1.455 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 2: Aeromonas hydrophila (ATCC 7966) MIC 167.35 ± 2.127 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: MIC
Value: 167.35 ± 2.127 µM
Target: Aeromonas hydrophila
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 2: Staphylococcus aureus (MTCC 9542) MIC 34.07 ± 1.632 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: MIC
Value: 34.07 ± 1.632 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 2: Bacillus subtilis (ATCC 6051) MIC 39.27 ± 1.359 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: MIC
Value: 39.27 ± 1.359 µM
Target: Bacillus subtilis
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 3: Aspergillus niger MFC 429.10 ± 2.216 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 429.10 ± 2.216 (MFC)
Target: Aspergillus niger
Assay: Not reported by source

Source publication

AntimicrobialAntifungalPositive observation

Table 3: A. fumigatus MFC 488.89 ± 3.317 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 488.89 ± 3.317 (MFC)
Target: Aspergillus fumigatus
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

The (HL50) 50% erythrolysis was only at 267.97 μM temporin-SHf concentration (Fig. 6). Temporin-SHf was non-hemolytic against human erythrocytes up to 120 μM.

Mention PMC10847208::PEP000001PMC10847208text

Measure: HD50
Value: 267.97 µM
Target: Homo sapiens
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: A549 IC50 6 h = 27.71 ± 1.150 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 27.71 ± 1.150 µM
Target: A549
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: A549 IC50 12 h = 26.27 ± 1.054 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 26.27 ± 1.054 µM
Target: A549
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: A549 IC50 24 h = 24.03 ± 0.945 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 24.03 ± 0.945 µM
Target: A549
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: A549 IC50 48 h = 21.85 ± 0.927 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 21.85 ± 0.927 µM
Target: A549
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: MCF-7 IC50 6 h = 35.77 ± 1.854 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 35.77 ± 1.854 µM
Target: MCF-7
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: MCF-7 IC50 12 h = 34.45 ± 1.645 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 34.45 ± 1.645 µM
Target: MCF-7
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: MCF-7 IC50 24 h = 32.76 ± 1.528 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 32.76 ± 1.528 µM
Target: MCF-7
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: MCF-7 IC50 48 h = 30.79 ± 1.197 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 30.79 ± 1.197 µM
Target: MCF-7
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: PC-3 IC50 6 h = 40.10 ± 0.721 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 40.10 ± 0.721 µM
Target: PC-3
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: PC-3 IC50 12 h = 38.62 ± 0.658 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 38.62 ± 0.658 µM
Target: PC-3
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: PC-3 IC50 24 h = 36.67 ± 0.729 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 36.67 ± 0.729 µM
Target: PC-3
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: PC-3 IC50 48 h = 35.05 ± 0.673 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 35.05 ± 0.673 µM
Target: PC-3
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: HepG2 IC50 6 h = 37.95 ± 1.111 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 37.95 ± 1.111 µM
Target: HepG2
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: HepG2 IC50 12 h = 35.31 ± 1.248 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 35.31 ± 1.248 µM
Target: HepG2
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: HepG2 IC50 24 h = 32.64 ± 1.350 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 32.64 ± 1.350 µM
Target: HepG2
Assay: Not reported by source

Source publication

AnticancerCytotoxicPositive observation

Table 4: HepG2 IC50 48 h = 30.32 ± 1.364 μM

Mention PMC10847208::PEP000001PMC10847208table

Measure: other
Value: 30.32 ± 1.364 µM
Target: HepG2
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.