ToxicityCytotoxicPositive observation
Record detail AR-23 consistently affected cell viability at 50 μM, and the 50% cytotoxic concentration was at 25 μM.
- Measure
- CC50
- Value
- 25 μM
- Target
- Vero
- Assay
- Not reported by source
Source publication
Melittin-Related Peptides Interfere with Sandfly Fever Naples Virus Infection by Interacting with Heparan Sulphate
Microorganisms · 2023
- Sequence status
- reported
- Standardization
- Sequence ready
- Source location
- unknown
- Activity records
- 4
Sequence evidence
Reported molecular identity
AIGSILGALAKGLPTLISWIKNR
AIGSILGALAKGLPTLISWIKNR
Resolved peptide links
Experimental observations
Records linked to this mention
AntiviralGeneral AntiviralPositive observation
Record detail RV-23 was found to be more active than AR-23, with an inhibitory concentration of 50% (IC50) at ... 12.5 μM in co-treatment.
- Measure
- other
- Value
- 12.5 μM
- Target
- Vero
- Assay
- Not reported by source
AntiviralGeneral AntiviralPositive observation
Record detail AR-23 was characterized by an IC50 at 10 μM in the same treatment (virus pre-treatment).
- Measure
- other
- Value
- 10 μM
- Target
- Vero
- Assay
- Not reported by source
AntiviralGeneral AntiviralNegative / threshold
Record detail On the contrary, no activity was observed after the viral adsorption step (post-treatment), indicating that the peptides did not interfere later in the infection.
- Measure
- percent_inhibition
- Value
- no activity
- Target
- Vero
- Assay
- Not reported by source
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.