Frontiers in Aging Neuroscience · 2023
Sequence evidence
YVRHDLYVRHDL
P12(Ac-YVRHDLYVRHDL-NH2) was purchased from GL Biochem Ltd. (Shanghai).
Experimental observations
Figure 3C: P12 has significant effect on the viability of PC12 cells at 6.25 uM (p < 0.05). But there was no significant difference at other concentrations.
Figure 4: compared with the Aβ positive control group, the fluorescence intensity of P9 and P12 polypeptides has increased, but the difference is not statistically significant (p > 0.05), indicating that P9 and P12 have no inhibitory effect on Aβ aggregation.
Table 3: KD (M) for P12 is 3.266 × 10−7.
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.
