Primary-literature peptidemedium evidence

PEPDIA-PLP-003359

P12

Aliases: P12

FASTA CSV JSON

Normalized sequence

YVRHDLYVRHDL

12 amino acids

Release PepDiana-V1-20260620

Activity records

Source papers

Positive

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

1585.7637 Da

Molecular formula

C72H108N22O19

Theoretical pI

6.919

Net charge at pH 7

-0.0653

GRAVY

-0.75

Instability index

41.2667

Aromaticity

0.1667

Topological polar surface area

679.64 Å²

cLogP

-3.5606

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

YVRHDLYVRHDL

HELM 2.0

validated simple linear

PEPTIDE1{Y.V.R.H.D.L.Y.V.R.H.D.L}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(CC(=O)O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C(C)C)C(C)C)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(C)C)C(=O)O

Paper-level observations

Experimental evidence grouped by activity

Other 2 records

PMC10126514

2 observations

OtherAnti-AggregationPositive observation

Record detail

Figure 4: compared with the Aβ positive control group, the fluorescence intensity of P9 and P12 polypeptides has increased, but the difference is not statistically significant (p > 0.05), indicating that P9 and P12 have no inhibitory effect on Aβ aggregation.

Mention PMC10126514::PEP000003PMC10126514text

Measure: percent_inhibition
Value: fluorescence intensity increased, no inhibitory effect (p>0.05)
Target: Aβ1-42
Assay: Not reported by source

Source publication

OtherBinding AffinityPositive observation

Record detail

Table 3: KD (M) for P12 is 3.266 × 10−7.

Mention PMC10126514::PEP000003PMC10126514table

Measure: Kd
Value: 3.266 × 10−7 M
Target: Aβ1-42
Assay: Not reported by source

Source publication

Toxicity 1 records

PMC10126514

1 observations

ToxicityCytotoxicNegative / threshold

Record detail

Figure 3C: P12 has significant effect on the viability of PC12 cells at 6.25 uM (p < 0.05). But there was no significant difference at other concentrations.

Mention PMC10126514::PEP000003PMC10126514text

Measure: cell_viability
Value: significant effect at 6.25 uM (p<0.05), no significant difference at other concentrations
Target: Rattus norvegicus
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-003359, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00