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Paper-scoped peptide mentionSequence reported

P11

PMC10126514::PEP000002

Source publication

The interaction of peptide inhibitors and Aβ protein: Binding mode analysis, inhibition of the formation of Aβ aggregates, and then exert neuroprotective effects.

Frontiers in Aging Neuroscience · 2023

DOI 10.3389/fnagi.2023.1139418PMC10126514PMID 37113572
Sequence status
reported
Standardization
Sequence ready
Source location
text
Activity records
3

Sequence evidence

Reported molecular identity

YVRHSVYVRHSV

P11(Ac-YVRHSVYVRHSV-NH2) was purchased from GL Biochem Ltd. (Shanghai).

Resolved peptide links

PEPDIA-PLP-003362

Experimental observations

Records linked to this mention

ToxicityCytotoxicNegative / threshold
Record detail

Figure 3B: cell viability began to decrease significantly at low concentration (3.125 uM) of P11 (p < 0.05), showing that this concentration can make cells significantly toxic (p < 0.05). Other concentrations also have significant effects on cell viability (p < 0.05).

Mention PMC10126514::PEP000002PMC10126514text
Measure
cell_viability
Value
cell viability decreased significantly at 3.125 uM (p<0.05) and other concentrations (p<0.05)
Target
Rattus norvegicus
Assay
Not reported by source
Source publication
OtherAnti-AggregationPositive observation
Record detail

Figure 4: The fluorescence intensity of P11 polypeptide decreased, but the difference was not statistically significant (p > 0.05), indicating that P11 has a certain inhibitory ability on Aβ aggregation.

Mention PMC10126514::PEP000002PMC10126514text
Measure
percent_inhibition
Value
fluorescence intensity decreased, but not statistically significant (p>0.05)
Target
Aβ1-42
Assay
Not reported by source
Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.