Paper-scoped peptide mentionSequence reported

SA626

PMC10045366::PEP000001

Source publication

Biological Activity of Cyclic Peptide Extracted from Sphaeranthus amaranthoides Using De Novo Sequencing Strategy by Mass Spectrometry for Cancer

Biology · 2023

DOI 10.3390/biology12030412 PMC10045366 PMID 36979104

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 2

Sequence evidence

Reported molecular identity

AAPSPSP

Resolved peptide links

PEPDIA-PLP-000018

Experimental observations

Records linked to this mention

AnticancerCytotoxicPositive observation

Record detail

The SA923 peptide exhibited a potent cytotoxic effect of 89%; when compared to the same dose of SA626, 37%; and SA905, 54%.

Mention PMC10045366::PEP000001PMC10045366text

Measure: percent_inhibition
Value: 37%
Target: 3T3
Assay: MTT assay

Source publication

ToxicityGeneral ToxicNegative / threshold

Record detail

Embryos exposed to different concentrations did not display any visible anomalies. ... peptides from S. amaranthoides do not demonstrate any toxic effect on embryos.

Mention PMC10045366::PEP000001PMC10045366text

Measure: qualitative
Value: no toxic effect
Target: Danio rerio
Assay: Zebrafish embryo toxicity test

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.