MetaADEDB 2.0 @ LMMD
valbenazine
(GEJDGVNQKABXKG-CFKGEZKQSA-N)
Structure
SMILES
COc1cc2c(cc1OC)CCN1[C@@H]2C[C@@H](OC(=O)[C@H](C(C)C)N)[C@@H](C1)CC(C)C
Type(s)
Approved; Investigational
ATC code(s)
N07XX13
Molecular Formula:
C24H38N2O4
Molecular Weight:
418.570
Log P:
4.2023
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
1
TPSA:
74.02
CAS Number(s):
1025504-45-3
Synonym(s)
1.
valbenazine
2.
(2R,3R,11BR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H- benzo(a)quinolizin-2-yl l-valinate
3.
NBI-98854
4.
valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester
External Link(s)
MeSHC000603978
PubChem Compound24795069
CHEMBLCHEMBL2364639
DrugBankDB11915
DrugCentral5227
IUPHAR/BPS Guide to PHARMACOLOGY8694
KEGGdr:D10675
Therapeutic Target DatabaseD0IX1I
ZINC43195697
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 678US FAERS
2SomnolenceFAERS: 654US FAERS
3FatigueFAERS: 493US FAERS
4TremorFAERS: 349US FAERS
5DizzinessFAERS: 240US FAERS
6DroolingFAERS: 178US FAERS
7NauseaFAERS: 158US FAERS
8Tardive DyskinesiaFAERS: 130US FAERS
9AnxietyFAERS: 120US FAERS
10Feeling abnormalFAERS: 114US FAERS
11RestlessnessFAERS: 108US FAERS
12Drug effect incompleteFAERS: 104US FAERS
13HeadacheFAERS: 103US FAERS
14AstheniaFAERS: 92US FAERS
15MalaiseFAERS: 85US FAERS
16VomitingFAERS: 82US FAERS
17LethargyFAERS: 77US FAERS
18ConstipationFAERS: 68US FAERS
19UrticariaFAERS: 58US FAERS
20AgitationFAERS: 44US FAERS
21Therapeutic product effect decreasedFAERS: 41US FAERS
22Abdominal discomfortFAERS: 40US FAERS
23Depressed moodFAERS: 38US FAERS
24AkathisiaFAERS: 36US FAERS
25NervousnessFAERS: 33US FAERS
26DysarthriaFAERS: 32US FAERS
27Therapeutic product effect incompleteFAERS: 29US FAERS
28ArthralgiaFAERS: 28US FAERS
29Musculoskeletal stiffnessFAERS: 26US FAERS
30PruritusFAERS: 24US FAERS
31Feeling jitteryFAERS: 23US FAERS
32Loss of personal independence in daily activitiesFAERS: 23US FAERS
33Memory impairmentFAERS: 23US FAERS
34PainFAERS: 23US FAERS
35AngerFAERS: 21US FAERS
36Chest PainFAERS: 21US FAERS
37HypersensitivityFAERS: 21US FAERS
38Restless Legs SyndromeFAERS: 21US FAERS
39BradykinesiaFAERS: 20US FAERS
40Urinary RetentionFAERS: 20US FAERS
41Adverse eventFAERS: 19US FAERS
42Weight decreasedFAERS: 19US FAERS
43Gait inabilityFAERS: 18US FAERS
44PalpitationsFAERS: 18US FAERS
45Urinary tract infectionFAERS: 17US FAERS
46Wrong technique in product usage processFAERS: 17US FAERS
47AlopeciaFAERS: 16US FAERS
48DehydrationFAERS: 14US FAERS
49PneumoniaFAERS: 14US FAERS
50Accidental overdoseFAERS: 13US FAERS
51AmnesiaFAERS: 13US FAERS
52Inappropriate schedule of drug administrationFAERS: 13US FAERS
53SluggishnessFAERS: 12US FAERS
54Chest discomfortFAERS: 10US FAERS
55CryingFAERS: 10US FAERS
56Drug dose omissionFAERS: 10US FAERS
57DysuriaFAERS: 10US FAERS
58Initial insomniaFAERS: 10US FAERS
59Urinary IncontinenceFAERS: 10US FAERS
60Drug ineffective for unapproved indicationFAERS: 9US FAERS
61IncontinenceFAERS: 9US FAERS
62Incorrect dose administeredFAERS: 9US FAERS
63Intentional product use issueFAERS: 9US FAERS
64Limb discomfortFAERS: 9US FAERS
65Lip swellingFAERS: 9US FAERS
66MyalgiaFAERS: 9US FAERS
67Back PainFAERS: 8US FAERS
68DiscomfortFAERS: 8US FAERS
69DisorientationFAERS: 8US FAERS
70DystoniaFAERS: 8US FAERS
71FlatulenceFAERS: 8US FAERS
72Mental impairmentFAERS: 8US FAERS
73Muscle tightnessFAERS: 8US FAERS
74Reduced facial expressionFAERS: 8US FAERS
75StressFAERS: 8US FAERS
76ApathyFAERS: 7US FAERS
77AphasiaFAERS: 7US FAERS
78BruxismFAERS: 7US FAERS
79ChillsFAERS: 7US FAERS
80Drug dispensing errorFAERS: 7US FAERS
81NasopharyngitisFAERS: 7US FAERS
82Product dose omissionFAERS: 7US FAERS
83Psychiatric decompensationFAERS: 7US FAERS
84SepsisFAERS: 7US FAERS
85Tongue movement disturbanceFAERS: 7US FAERS
86VertigoFAERS: 7US FAERS
87Visual ImpairmentFAERS: 7US FAERS
88DyspepsiaFAERS: 6US FAERS
89Eyelid Function DisorderFAERS: 6US FAERS
90General physical health deteriorationFAERS: 6US FAERS
91InfluenzaFAERS: 6US FAERS
92Mental status changesFAERS: 6US FAERS
93Middle insomniaFAERS: 6US FAERS
94Muscle RigidityFAERS: 6US FAERS
95Myocardial InfarctionFAERS: 6US FAERS
96ParanoiaFAERS: 6US FAERS
97RetchingFAERS: 6US FAERS
98Slow speechFAERS: 6US FAERS
99SomnambulismFAERS: 6US FAERS
100SyncopeFAERS: 6US FAERS
101TrismusFAERS: 6US FAERS
102CatatoniaFAERS: 5US FAERS
103Cold sweatFAERS: 5US FAERS
104DysgeusiaFAERS: 5US FAERS
105Head titubationFAERS: 5US FAERS
106Impaired driving abilityFAERS: 5US FAERS
107Inappropriate schedule of product administrationFAERS: 5US FAERS
108Intentional self-injuryFAERS: 5US FAERS
109Joint stiffnessFAERS: 5US FAERS
110Mood swingsFAERS: 5US FAERS
111Oral painFAERS: 5US FAERS
112SwellingFAERS: 5US FAERS
113Abdominal PainFAERS: 4US FAERS
114ArthritisFAERS: 4US FAERS
115Atrial FibrillationFAERS: 4US FAERS
116Blood glucose increasedFAERS: 4US FAERS
117BradyphreniaFAERS: 4US FAERS
118BronchitisFAERS: 4US FAERS
119ChromaturiaFAERS: 4US FAERS
120DeliriumFAERS: 4US FAERS
121Depressed Level of ConsciousnessFAERS: 4US FAERS
122Emotional disorderFAERS: 4US FAERS
123Emotional distressFAERS: 4US FAERS
124EpistaxisFAERS: 4US FAERS
125HypophagiaFAERS: 4US FAERS
126Peripheral swellingFAERS: 4US FAERS
127Personality ChangeFAERS: 4US FAERS
128Poor quality sleepFAERS: 4US FAERS
129Psychiatric symptomFAERS: 4US FAERS
130Respiratory FailureFAERS: 4US FAERS
131SchizophreniaFAERS: 4US FAERS
132SinusitisFAERS: 4US FAERS
133TachyphreniaFAERS: 4US FAERS
134AngioedemaFAERS: 3US FAERS
135Bipolar DisorderFAERS: 3US FAERS
136BlepharospasmFAERS: 3US FAERS
137Blood sodium decreasedFAERS: 3US FAERS
138Bone painFAERS: 3US FAERS
139Cerebrovascular accidentFAERS: 3US FAERS
140CystitisFAERS: 3US FAERS
141DiplopiaFAERS: 3US FAERS
142DysphoniaFAERS: 3US FAERS
143Eating disorder symptomFAERS: 3US FAERS
144ErythemaFAERS: 3US FAERS
145Euphoric moodFAERS: 3US FAERS
146Head discomfortFAERS: 3US FAERS
147HungerFAERS: 3US FAERS
148HypokinesiaFAERS: 3US FAERS
149IncoherentFAERS: 3US FAERS
150InfectionFAERS: 3US FAERS
151Intentional dose omissionFAERS: 3US FAERS
152Joint swellingFAERS: 3US FAERS
153Mastication disorderFAERS: 3US FAERS
154Neck PainFAERS: 3US FAERS
155Night sweatsFAERS: 3US FAERS
156Oromandibular dystoniaFAERS: 3US FAERS
157Oropharyngeal painFAERS: 3US FAERS
158OverdoseFAERS: 3US FAERS
159PancreatitisFAERS: 3US FAERS
160Psychotic symptomFAERS: 3US FAERS
161StaringFAERS: 3US FAERS
162Throat irritationFAERS: 3US FAERS
163Tongue bitingFAERS: 3US FAERS
164WheezingFAERS: 3US FAERS
165AkinesiaFAERS: 2US FAERS
166Ankle FractureFAERS: 2US FAERS
167ArthropathyFAERS: 2US FAERS
168Blood prolactin increasedFAERS: 2US FAERS
169Burning sensationFAERS: 2US FAERS
170Cardiac FlutterFAERS: 2US FAERS
171ChokingFAERS: 2US FAERS
172Completed SuicideFAERS: 2US FAERS
173DementiaFAERS: 2US FAERS
174Drug effect variableFAERS: 2US FAERS
175Drug prescribing errorFAERS: 2US FAERS
176Dry skinFAERS: 2US FAERS
177Ear discomfortFAERS: 2US FAERS
178Emergency CareFAERS: 2US FAERS
179Eye painFAERS: 2US FAERS
180FormicationFAERS: 2US FAERS
181HerniaFAERS: 2US FAERS
182HypersomniaFAERS: 2US FAERS
183HyperventilationFAERS: 2US FAERS
184ImpatienceFAERS: 2US FAERS
185InflammationFAERS: 2US FAERS
186Intrusive thoughtsFAERS: 2US FAERS
187Lack of spontaneous speechFAERS: 2US FAERS
188Medication ErrorFAERS: 2US FAERS
189Mouth swellingFAERS: 2US FAERS
190Musculoskeletal PainFAERS: 2US FAERS
191Nasal pruritusFAERS: 2US FAERS
192Negative thoughtsFAERS: 2US FAERS
193NocturiaFAERS: 2US FAERS
194PallorFAERS: 2US FAERS
195Product use in unapproved indicationFAERS: 2US FAERS
196Rash erythematousFAERS: 2US FAERS
197Sexual DysfunctionFAERS: 2US FAERS
198Sleep TalkingFAERS: 2US FAERS
199StomatitisFAERS: 2US FAERS
200StuporFAERS: 2US FAERS
201TachycardiaFAERS: 2US FAERS
202Therapy cessationFAERS: 2US FAERS
203ThrombosisFAERS: 2US FAERS
204TinnitusFAERS: 2US FAERS
205TonsillitisFAERS: 2US FAERS
206ToothacheFAERS: 2US FAERS
207TorticollisFAERS: 2US FAERS
208TrichorrhexisFAERS: 2US FAERS
209YawningFAERS: 2US FAERS
210AcneFAERS: 1US FAERS
211Alanine Aminotransferase IncreasedFAERS: 1US FAERS
212Alcohol poisoningFAERS: 1US FAERS
213Angina PectorisFAERS: 1US FAERS
214Anticholinergic SyndromeFAERS: 1US FAERS
215Arthropod stingFAERS: 1US FAERS
216Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
217AsthmaFAERS: 1US FAERS
218AtaxiaFAERS: 1US FAERS
219Atypical pneumoniaFAERS: 1US FAERS
220BabesiosisFAERS: 1US FAERS
221BedriddenFAERS: 1US FAERS
222BelligerenceFAERS: 1US FAERS
223Bipolar I disorderFAERS: 1US FAERS
224Bipolar II disorderFAERS: 1US FAERS
225Bladder spasmFAERS: 1US FAERS
226Blood count abnormalFAERS: 1US FAERS
227Blood glucose abnormalFAERS: 1US FAERS
228Blood glucose decreasedFAERS: 1US FAERS
229Blood iron decreasedFAERS: 1US FAERS
230Blood magnesium decreasedFAERS: 1US FAERS
231Blood magnesium increasedFAERS: 1US FAERS
232Blood potassium decreasedFAERS: 1US FAERS
233Blood potassium increasedFAERS: 1US FAERS
234Blood pressure fluctuationFAERS: 1US FAERS
235Blood urine presentFAERS: 1US FAERS
236BradycardiaFAERS: 1US FAERS
237CataractFAERS: 1US FAERS
238Cerebral InfarctionFAERS: 1US FAERS
239Clostridium difficile infectionFAERS: 1US FAERS
240ClumsinessFAERS: 1US FAERS
241Coating in mouthFAERS: 1US FAERS
242Coronary Artery DiseaseFAERS: 1US FAERS
243Diabetes mellitus inadequate controlFAERS: 1US FAERS
244DissociationFAERS: 1US FAERS
245Drug DependenceFAERS: 1US FAERS
246Drug effect delayedFAERS: 1US FAERS
247DysgraphiaFAERS: 1US FAERS
248Electrolyte imbalanceFAERS: 1US FAERS
249Emotional povertyFAERS: 1US FAERS
250Expired product administeredFAERS: 1US FAERS
251Extra dose administeredFAERS: 1US FAERS
252Facial ParesisFAERS: 1US FAERS
253Facial paralysisFAERS: 1US FAERS
254Feeling ColdFAERS: 1US FAERS
255Flat affectFAERS: 1US FAERS
256FlushingFAERS: 1US FAERS
257Foaming at mouthFAERS: 1US FAERS
258Frustration tolerance decreasedFAERS: 1US FAERS
259Gastric infectionFAERS: 1US FAERS
260GastritisFAERS: 1US FAERS
261Gastrointestinal motility disorderFAERS: 1US FAERS
262General symptomFAERS: 1US FAERS
263Gingival discomfortFAERS: 1US FAERS
264Hallucinations, mixedFAERS: 1US FAERS
265Hand-eye coordination impairedFAERS: 1US FAERS
266Heat StrokeFAERS: 1US FAERS
267HemiparesisFAERS: 1US FAERS
268Hilar lymphadenopathyFAERS: 1US FAERS
269HostilityFAERS: 1US FAERS
270HypotensionFAERS: 1US FAERS
271IleusFAERS: 1US FAERS
272ImmobileFAERS: 1US FAERS
273Impaired gastric emptyingFAERS: 1US FAERS
274Inappropriate PrescribingFAERS: 1US FAERS
275Increased tendency to bruiseFAERS: 1US FAERS
276Increased upper airway secretionFAERS: 1US FAERS
277Infrequent bowel movementsFAERS: 1US FAERS
278Injection site painFAERS: 1US FAERS
279Irregular sleep phaseFAERS: 1US FAERS
280Joint InstabilityFAERS: 1US FAERS
281Joint injuryFAERS: 1US FAERS
282LacerationFAERS: 1US FAERS
283LeukopeniaFAERS: 1US FAERS
284Limb operationFAERS: 1US FAERS
285Lyme DiseaseFAERS: 1US FAERS
286Mallet fingerFAERS: 1US FAERS
287MonoplegiaFAERS: 1US FAERS
288Morbid thoughtsFAERS: 1US FAERS
289Muscle strainFAERS: 1US FAERS
290MydriasisFAERS: 1US FAERS
291NarcolepsyFAERS: 1US FAERS
292NephrolithiasisFAERS: 1US FAERS
293NeuralgiaFAERS: 1US FAERS
294Obsessive-Compulsive DisorderFAERS: 1US FAERS
295Occupational exposure to productFAERS: 1US FAERS
296Oral mucosal exfoliationFAERS: 1US FAERS
297Orthostatic hypertensionFAERS: 1US FAERS
298Paranasal sinus discomfortFAERS: 1US FAERS
299Paranasal sinus hyposecretionFAERS: 1US FAERS
300Pericardial effusionFAERS: 1US FAERS
301Pharyngeal swellingFAERS: 1US FAERS
302PneumonitisFAERS: 1US FAERS
303Poor peripheral circulationFAERS: 1US FAERS
304Poor quality product administeredFAERS: 1US FAERS
305Post procedural complicationFAERS: 1US FAERS
306PresyncopeFAERS: 1US FAERS
307Procedural complicationFAERS: 1US FAERS
308Product dispensing errorFAERS: 1US FAERS
309Product physical issueFAERS: 1US FAERS
310Product supply issueFAERS: 1US FAERS
311Product use complaintFAERS: 1US FAERS
312Renal painFAERS: 1US FAERS
313Resting TremorFAERS: 1US FAERS
314RhinitisFAERS: 1US FAERS
315SarcoidosisFAERS: 1US FAERS
316SciaticaFAERS: 1US FAERS
317Seasonal Affective DisorderFAERS: 1US FAERS
318Seizure like phenomenaFAERS: 1US FAERS
319Sinus operationFAERS: 1US FAERS
320Sleep ParalysisFAERS: 1US FAERS
321SneezingFAERS: 1US FAERS
322SoliloquyFAERS: 1US FAERS
323Spinal cord abscessFAERS: 1US FAERS
324Status EpilepticusFAERS: 1US FAERS
325Suicide attemptFAERS: 1US FAERS
326Tension HeadacheFAERS: 1US FAERS
327TensionFAERS: 1US FAERS
328Terminal stateFAERS: 1US FAERS
329Therapeutic response unexpectedFAERS: 1US FAERS
330Therapy changeFAERS: 1US FAERS
331Tongue discomfortFAERS: 1US FAERS
332Tongue exfoliationFAERS: 1US FAERS
333Tooth InfectionFAERS: 1US FAERS
334Troponin increasedFAERS: 1US FAERS
335Unevaluable eventFAERS: 1US FAERS
336Unresponsive to stimuliFAERS: 1US FAERS
337Upper-airway cough syndromeFAERS: 1US FAERS
338Urine amphetamine positiveFAERS: 1US FAERS
339Vascular painFAERS: 1US FAERS
340White blood cell count decreasedFAERS: 1US FAERS
341Wound InfectionFAERS: 1US FAERS
342cancer surgeryFAERS: 1US FAERS
343nervous system disorderFAERS: 1US FAERS
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.