Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 883
Aptamer sequence: GTTCGTGGTGTGCTGGATGTCCCGTGCACGGCGCCACGTTTTCCTCTCATCCCCGATGACACATCCAGCAGCACGA
Target unique ID: CRL-2945
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_799 | Apoc37 | Cell | Primary serous ovarian cancer (pSOC) cells | 10.72 μM | PBS | 33787226 |
Structure information of aptamer
| Aptamer Sequence: | GTTCGTGGTGTGCTGGATGTCCCGTGCACGGCGCCACGTTTTCCTCTCATCCCCGATGACACATCCAGCAGCACGA |
| The optimal secondary structure in dot-bracket notation: | ..(((((...((((((((((..(((((.....)).)))........(((((...))))).)))))))))).))))) |
| The centroid secondary structure in dot-bracket notation: | ..(((((...((((((((((..(((..........)))........(((((...))))).)))))))))).))))) |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_799 | Description | Apoc37 |
| Aptamer chemistry | DNA | Length | 76 nt |
| GC content | 60.5% | Molecular weight | 23,274.84 Da |
| Molarity of 1 μg/μl solution | 42.96 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted therapy |
| Sequence | GTTCGTGGTGTGCTGGATGTCCCGTGCACGGCGCCACGTTTTCCTCTCATCCCCGATGACACATCCAGCAGCACGA | ||
| Applications | Molecular tools for rapid intraoperative diagnosis and In vivo imaging of serous ovarian cancer | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| ATCC ID | CRL-2945 | Cell name | Primary serous ovarian cancer (pSOC) cells |
| Category | Human cells | Organism | Homo sapiens, human |
| Product type | N/A | Cell type | N/A |
| Morphology | epithelial-like | Tissue | Ovary |
| Disease | Carcinoma | Product format | Frozen |
| Antigen expression | Cytokeratin 7 (CK-7), positive; calretinin, positive | Genes expressed | p53; cytokeratin 7 (CK-7) positive; calretinin positive; Wilms' tumor protein (WT) positive; BRCA1 negative |
| Cell description | N/A |
|
|
| Application(s) | 3D cell culture; Cancer research | ||
Activity data
|
No relevant experimental diagram |
Interaction ID | 883 |
| Target type | Cell | |
| Target unique ID | CRL-2945 | |
| Activity | 10.72 μM | |
| Binding Conditions/Buffer | PBS |
|
| Assay | N/A |
|
| PubMed ID | 33787226 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_797 | DNA | GTTCGTGGTGTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAGCAGCACGA | |
| Apta_798 | DNA | GTTCGTGGTGTGCTGGATGTCGGAGATGGTCCGCTTCGTTCAACTACTACGCATTTTGACACATCCAGCAGCACGA | |
| Apta_796 | DNA | GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG | |
| Apta_435 | DNA | CCTTCGTTGTCTGCCTTCGTAGGACCGCAGACATCGACGCAGGGAAATTCCGCAAGTCCAGCCAAATGCCACCCTTCAGAATTCGCACCA | |
| Apta_558 | DNA | CCGGTGGGTGGTCAGGTGGGATAGCGTTCCGCGTATGGCCCAGCGCATCACGGGTTCGCACCA | |
| Apta_1072 | DNA | TTGAAGTGACTCCCACCCCGCCCCACCGTCCTTGCCACCGTTCCGCCATAGCAGGT | |
| Apta_1116 | DNA | CGTACGGAATTCGCTAGCCGGGGTGGGAACCAGTCTTGCGCGGGTGACGGATCCGAGCTCCACGTG | |
| Apta_1291 | DNA | CGTACGGAATTCGCTAGCCCCCCGGCAGGCCACGGCTTGGGTTGGTCCCACTGCGCGTGGATCCGAGCTCCACGTG | |
| Apta_1182 | DNA | GAATTCAGTCGGACAGCGTCAGTCGTCCCTTTATGCTTGGTGCTCACCGTCTGAATTTCTTCAGATGGACGAATATCGTCTCCC | |
| Apta_1184 | DNA | GAATTCAGTCGGACAGCGTAATCCCTTGTGTTTGACGTTCGAAGATTATTTCTATCTTTTAGGATGGACGAATATCGTCTCCC | |
| Apta_933 | DNA | GACGCTTACTCAGGTGTGACTCGGGGTGTAGCTCGTTATGATTCGGACAAGACTTACCTTGCGCCTCTGGGATCGAAGGACGCAGATGAAGTCTC | |
| Apta_277 | DNA | TTTTTTGGTCAGATGAGGCCTGGTGATCGTGCCCAGGCCATATGAGCAAGGAACCCCTATGCGTGCT | |
| Apta_321 | DNA | AACCGCCCAAATCCCTAAGAGTCGGACTGCAACCTATGCTATCGTTGATGTCTGTCCAAGCAACACAGACACACTACACACGCACA | |
| Apta_510 | DNA | TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA | |
| Apta_600 | DNA | GTCTCTGTGTGCGCCAGAGAACACTGGGGCAGATATGGGCCAGCACAGAATGAGGCCC | |
| Apta_621 | DNA | AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC | |
| Apta_935 | DNA | GACGCTTACTCAGGTGTGACTCGTCCGTCGGTTCGCCTTGCGAGTGCACGCCGCCAGCCGTTACATAAAGTCTGCCCACTCGAAGGACGCAGATGAAGTCTC | |
| Apta_982 | DNA | ATGACGGGGGTCTAGGCAAGTAATAACGGGGGCAAGCTTTTCTATCTCGTTCTAGGGTA | |
| Apta_1030 | DNA | CTTCTGCCCGCCTCCTTCCCGGGTTACAGGATCGTAAATCTTATTCGTTGCTCGATCGGGAGACGAGATAGGCGGACACT | |
| Apta_1073 | DNA | CTTCTGCCCGCCTCCTTCCTATTAGGGTGCTTCGCGAAGTTCATTTTACATCCCCATAGGAGACGAGATAGGCGGACACT |
DEV TOOL
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