Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 793
Aptamer sequence: GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC
Target unique ID: 2153
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_717 sequence 6 (S6) Molecule Theophylline 0.264 μM 100 mM HEPES, 50 mM NaCl, and 10 mM MgCl2 26642994
Structure information of aptamer
Aptamer Sequence: GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC
The optimal secondary structure in dot-bracket notation: ((((...((.(((....)))....))...))))
The centroid secondary structure in dot-bracket notation: ((((...((((((....)))..).))...))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_717 Description sequence 6 (S6)
Aptamer chemistry RNA Length 33 nt
GC content 72.7% Molecular weight 10,659.45 Da
Molarity of 1 μg/μl solution 93.81 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC
Applications Binding to theophylline
Target information
Type Detail Type Detail
PubChem ID 2153 Molecular name Theophylline
Molecular formula C7H8N4O2 Molecular weight 180.16
IUPAC name 1,3-dimethyl-7H-purine-2,6-dione InChIKey ZFXYFBGIUFBOJW-UHFFFAOYSA-N
LogP -1.04 Topological polar surface area 72.68
Hydrogen bond acceptor 5 Hydrogen bond donor 1

Synonym(s):
theophylline; 58-55-9; 1,3-Dimethylxanthine; Elixophyllin; Theophyllin; Theolair; Nuelin; Theophylline anhydrous; Respbid; Theocin; Theo-dur; Elixophylline; Pseudotheophylline; Lanophyllin; Theovent; Uniphyl; Slo-phyllin; Accurbron; Armophylline; Bronkodyl; Doraphyllin; Liquophylline; Maphylline; Medaphyllin; Optiphyllin; Parkophyllin; Synophylate; Teofyllamin; Theacitin; Theocontin; Uniphyllin; Xantivent; Aerolate; Elixicon; Solosin; Teolair; Theobid; Theofol; Theograd; Theolix; Elixex; Acet-theocin; Slo-bid; Theophyl-225; Aerolate III; Duraphyl; Euphylong; Sustaire; Xanthium; Austyn; Somophyllin-t; Constant-T; Teofilina; Theochron; Asmax; Quibron T/SR; Theal tablets; 1,3-dimethyl-7H-purine-2,6-dione; Somophyllin-DF; Bronkodyl SR; Theoclair-SR; Theoclear LA; Spophyllin retard; Choledyl SA; Quibron-T; Theoclear 80; Theophyline; Theo-11; Theo-24; Theostat 80; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione; Synophylate-L.A. Cenules; Theophylline, anhydrous; Theo-Dur-Sprinkle; Aquaphyllin; Tefamin; Theodel; Unifyl; Theona P; 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione; LaBID; Euphylline; Elixomin; Theolixir; Theophyl; Bronkotabs; Elixophyllin SR; Theophylline-SR; Somophyllin-CRT; Aerolate SR; Theo-Organidin; Theolair-SR; Theophyl-SR; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-; GS 2591A; Uni-Dur; Theoclear-80; Quibron-T/SR; T-Phyl; Theoclear-200; Xanthine, 1,3-dimethyl-; Dimethylxanthine; NSC 2066; X 115; Quadrinal; Theobid Jr.; Theoclear L.A.-130; Theal tabl.; 1,3-dimethyl-1H-purine-2,6(3H,7H)-dione; 1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; UNII-0I55128JYK; 2,6-Dihydroxy-1,3-dimethylpurine; Purine-2,6(1H,3H)-dione, 1,3-dimethyl-; Aerobin; Theodur; Theopek; Theospan; CHEMBL190; Theophylline [USP]; 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-; MLS000069390; 1,3-Dimethylxanthine;Theo-24; Diffumal; 1,3-dimethyl-1H-purine-2,6(3H,9H)-dione; CHEBI:28177; LASMA; 0I55128JYK; Pro-vent; Theophylline melting point standard; NSC-2066; 58-55-9 (ANHYDROUS); MFCD00079619; Teofilina [Polish]; NCGC00018117-07; NCGC00018117-17; Mudrane; Pulmidur; SMR000058537; Teonova; Theokin; Hylate; DSSTox_CID_1336; Nuelin SA; Bronchodid Duracap; DSSTox_RID_76090; Uniphyllin continus; DSSTox_GSID_21336; Teocen 200; Elixophyllin(e); CAS-58-55-9; Theolair (TN); Elixophyllin (TN); Uniphyl (TN); Quibron-t (TN); Theodur G (TN); CCRIS 4729; HSDB 3399; 1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione; SR-01000075195; EINECS 200-385-7; Theo-24 (TN); Telbans; Physpa; AI3-50216; Unicontin CR; 4eoh; Aescin-IIA; 1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine; Theophylline form II; theophylline solu-tion; component of Primatene; Xanthine,3-dimethyl-; Opera_ID_76; Spectrum_001038; Theophylline (JP17); 2a3a; Prestwick0_000820; Prestwick0_000873; Prestwick1_000820; Prestwick1_000873; Prestwick2_000820; Prestwick2_000873; Prestwick3_000820; Prestwick3_000873; Spectrum2_000842; Spectrum3_000672; Spectrum4_000353; Spectrum5_001232; 8-(2-Furyl)theophylline; UPCMLD-DP123; component of Theo-Organidin; EC 200-385-7; SCHEMBL4915; Theophylline Anhydrous,(S); 1,3-dimethyl-1,3,7-trihydropurine-2,6-dione; Theophylline Anhydrous, USP; Lopac0_000014; BSPBio_000719; BSPBio_000945; BSPBio_002363; component of Dicurin Procaine; GTPL413; KBioGR_000785; KBioSS_001518; MLS002152943; MLS002153487; MLS004491910; MLS006011970; BIDD:ER0557; BIDD:GT0151; DivK1c_000203; SPECTRUM1500568; SPBio_000823; SPBio_002640; SPBio_002866; BPBio1_000791; BPBio1_001041; SCHEMBL8312163; component of Tedral (Salt/Mix); DTXSID5021336; UPCMLD-DP123:001; BCBcMAP01_000071; BDBM10847; BDBM82053; component of Quibron (Salt/Mix); HMS500K05; KBio1_000203; KBio2_001518; KBio2_004086; KBio2_006654; KBio3_001583; NSC2066; component of Hecadrol (Salt/Mix); NINDS_000203; HMS1921E03; HMS2089A06; HMS2092M05; HMS2233E16; HMS3259O06; HMS3369N14; Pharmakon1600-01500568; component of Primatene (Salt/Mix); BCP30664; component of Bronkotabs (Salt/Mix); HY-B0809; STR01537; Theophylline 1.0 mg/ml in Methanol; Theophylline, >=99.0% (HPLC); Theophylline-[1,3-15N2,13C]; Tox21_110827; Tox21_202375; Tox21_300028; BBL023514; CCG-20301; NSC757346; PDSP1_001018; PDSP1_001234; PDSP2_001002; PDSP2_001218; STK397040; Theophylline (1,3-dimethylxanthine); ZINC18043251; AKOS000120961; AKOS005434016; component of Quibron Plus (Salt/Mix); Tox21_110827_1; component of Quibron-T/SR (Salt/Mix); component of Theo-organdin (Salt/Mix); component of Theolair plus (Salt/Mix); CS-4158; DB00277; MCULE-8236489917; NC00542; NSC-757346; Purine-2,3H)-dione, 1,3-dimethyl-; SDCCGMLS-0066620.P001; SDCCGSBI-0050003.P005; component of Theo-Organidin (Salt/Mix); IDI1_000203; SMP1_000291; component of Slo-phyllin GG (Salt/Mix); NCGC00018117-01; NCGC00018117-02; NCGC00018117-03; NCGC00018117-04; NCGC00018117-05; NCGC00018117-06; NCGC00018117-08; NCGC00018117-09; NCGC00018117-10; NCGC00018117-11; NCGC00018117-12; NCGC00018117-13; NCGC00018117-14; NCGC00018117-15; NCGC00018117-16; NCGC00018117-18; NCGC00018117-19; NCGC00018117-20; NCGC00018117-23; NCGC00018117-37; NCGC00022112-03; NCGC00022112-04; NCGC00022112-05; NCGC00022112-07; NCGC00022112-08; NCGC00022112-09; NCGC00022112-10; NCGC00022112-11; NCGC00022112-12; NCGC00254040-01; NCGC00259924-01; WLN: T56 BM DN FNVNVJ F1 H1; AC-20328; component of Dicurin Procaine (Salt/Mix); NCI60_001736; SMR003435989; Theophylline, anhydrous, >=99%, powder; component of Primatene tablets (Salt/Mix); Purine,6(1H,3H)-dione, 1,3-dimethyl-; SBI-0050003.P004; component of Mudrane GG elixir (Salt/Mix); DB-053224; Theophylline 100 microg/mL in Acetonitrile; 1H-Purine-2, 3,7-dihydro-1,3-dimethyl-; AB00052106; FT-0631259; FT-0675140; N1442; T0179; 6461-EP1441224A2; 6461-EP2272835A1; 6461-EP2272841A1; 6461-EP2272844A1; 6461-EP2280006A1; 6461-EP2281813A1; 6461-EP2281815A1; 6461-EP2286811A1; 6461-EP2295434A2; 6461-EP2298305A1; 6461-EP2301933A1; 6461-EP2301936A1; 6461-EP2301937A1; 6461-EP2305219A1; 6461-EP2305640A2; 6461-EP2308562A2; 6461-EP2311827A1; 6461-EP2314590A1; C07130; D00371; D85002; 83377-EP2371823A1; AB00052106-20; AB00052106-22; AB00052106-23; AB00052106_24; AB00052106_25; AB00052106_26; A900445; L000595; Q407308; 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione #; Q-201819; SR-01000075195-1; SR-01000075195-3; SR-01000075195-5; 1,3-Dimethyl-6-hydroxy-1,3-dihydro-2H-purin-2-one; BRD-K97799481-001-02-0; BRD-K97799481-001-12-9; BRD-K97799481-002-03-6; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, mo; F2173-0145; Z271004650; A3133D49-AAB6-49A1-B60B-B5198F327D3F; Theophylline, British Pharmacopoeia (BP) Reference Standard; Theophylline, European Pharmacopoeia (EP) Reference Standard; (8alpha, 9S)-10,11-Dihydro-6'-methoxycinchonan-9-amine trihydrochloride, min. 90%; Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard; Theophylline solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material; 1246816-25-0; 50857-74-4; 75448-53-2; Theo-24;1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione ;1,3-Dimethylxanthine;1,3-dimethyl-xanthin; Theophylline melting point standard, Pharmaceutical Secondary Standard; Certified Reference Material; Theophylline, certified reference material, United States Pharmacopeia (USP) Reference Standard

Activity data

No relevant experimental diagram

Interaction ID 793
Target type Molecule
Target unique ID 2153
Activity 0.264 μM
Binding Conditions/Buffer

100 mM HEPES, 50 mM NaCl, and 10 mM MgCl2

Assay

N/A

PubMed ID 26642994
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_715 RNA GGCGCUGCACGCCGAAAGGCCCGUUGAAACGUC
84.85%
Apta_712 RNA GGCGGUGCUCGCCGAAAGGCUCCUGGAUACGUC 78.79%
Apta_713 RNA GGCGGUGCUGGCCGAAAGGCGCUUGGAAACGUC 78.79%
Apta_714 RNA GGCGGUUCCUGCCGAAAGGCUCGUGGCAACGUC 78.79%
Apta_711 RNA GGCGAUACCAGCCGAAAGGCCCUUGGCAGCGUC 75.76%
Apta_716 RNA GGCGCUUCAUGCCGAAAGGCCCGUUGUAACGUC 75.76%
Apta_370 RNA GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG 55.26%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 55.26%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 55.26%
Apta_1215 DNA GTCGAATCAGCACCTCTGCATAGGTTACGTTTATACTGCG 55.00%
Apta_138 RNA GGAGGUGCUCCGAAAGGAACUCC 54.55%
Apta_361 DNA GGGAACGCCCGTATTGCTCGGTTCCC 54.55%
Apta_362 DNA GGGAACGCACCGATCGCAGGTTTCCC 54.55%
Apta_630 DNA GACCAGGGCAAACGGTAGGGAGTGGTC 54.55%
Apta_3 DNA CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC 53.49%
Apta_1288 RNA GGCGCACUGGCGCUGCGCCUUCGGGCGCCAAUCGUAGCGUGUCGGCGCC 53.06%
Apta_56 DNA GCAGCTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGC 52.50%
Apta_967 DNA GGGTAGCAGCCCCGCGGAGGGTCGGCTATAAGAACCAAGA 52.50%
Apta_329 DNA GGCGTACGGTAGGCGGGGTCAACTG 51.52%
Apta_358 DNA GGGAATCGCCACCCGACGCAGGGTTTCCC 51.52%