Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 770
Aptamer sequence: AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG
Target unique ID: 38779
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_622 | SS4-54 | Molecule | Profenofos | 1.25 μM | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 | 22261866 |
Structure information of aptamer
| Aptamer Sequence: | AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG |
| The optimal secondary structure in dot-bracket notation: | ...(((((((....(((((..((((((...))))))..)))))..))))))).. |
| The centroid secondary structure in dot-bracket notation: | ...(((((((....(((((..((((((...))))))..)))))..))))))).. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_622 | Description | SS4-54 |
| Aptamer chemistry | DNA | Length | 54 nt |
| GC content | 46.3% | Molecular weight | 16,675.71 Da |
| Molarity of 1 μg/μl solution | 59.97 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG | ||
| Applications | Analysis and neutralization of the residues of the four organophosphorus pesticides | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 38779 | Molecular name | Profenofos |
| Molecular formula | C11H15BrClO3PS | Molecular weight | 373.63 |
| IUPAC name | 4-bromo-2-chloro-1-[ethoxy(propylsulfanyl)phosphoryl]oxybenzene | InChIKey | QYMMJNLHFKGANY-UHFFFAOYSA-N |
| LogP | 5.769 | Topological polar surface area | 35.53 |
| Hydrogen bond acceptor | 4 | Hydrogen bond donor | 0 |
Synonym(s): PROFENOFOS; 41198-08-7; Curacron; Selecron; Polycron; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester; O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate; 4-bromo-2-chloro-1-[ethoxy(propylsulfanyl)phosphoryl]oxybenzene; BRN 2150258; Profenophos; CHEBI:38845; O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propyl phosphorothioate; o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate; (+)-Profenofos; (-)-Profenofos; o-4-bromo-2-chlorophenyl o-ethyl s-propyl phosphorothioate; Caswell No. 266AA; CGA 15324; Profenofos [ANSI:BSI:ISO]; HSDB 6992; C11H15BrClO3PS; EINECS 255-255-2; EPA Pesticide Chemical Code 111401; AI3-29236; CCRIS 9291; 81123-19-5; (R)-O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate; (S)-O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl)-O-ethyl S-propyl ester; EC 255-255-2; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester, (R)-; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester, (S)-; DSSTox_CID_12464; DSSTox_RID_78950; DSSTox_GSID_32464; SCHEMBL25281; Profenofos, analytical standard; CHEMBL2138242; DTXSID3032464; O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propylphosphorothioate; Tox21_300752; AKOS015899345; Profenofos 100 microg/mL in Methanol; Profenofos 1000 microg/mL in Acetone; Profenofos 1000 microg/mL in Toluene; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester (9CI); Profenofos 10 microg/mL in Cyclohexane; NCGC00164297-01; NCGC00164297-02; NCGC00164297-03; NCGC00254657-01; Profenofos 100 microg/mL in Cyclohexane; 81116-98-5; I562; CAS-41198-08-7; DB-049725; FT-0630618; Profenofos, PESTANAL(R), analytical standard; C18404; 198P087; Q2111894; UNII-7J04O7BS4W component QYMMJNLHFKGANY-QGZVFWFLSA-N; o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate #
Activity data
 |
Interaction ID | 660 |
| Target type | Molecule | |
| Target unique ID | 90479 | |
| Activity | 0.9 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 752 |
| Target type | Molecule | |
| Target unique ID | 14210 | |
| Activity | 2 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 766 |
| Target type | Molecule | |
| Target unique ID | 4790 | |
| Activity | 1.43 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 770 |
| Target type | Molecule | |
| Target unique ID | 38779 | |
| Activity | 1.25 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_621 | DNA | AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC | |
| Apta_510 | DNA | TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA | |
| Apta_1061 | DNA | TATTTATTGAATGCTGTAATTTCGCCACGCGAAAGTAGG | |
| Apta_340 | DNA | TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA | |
| Apta_348 | DNA | ACTTGCTCTGATGCGACAACCTTTTGCCCAGATAGTAAGT | |
| Apta_489 | DNA | GGGGTTAAATATTCCCACATTGCCTGCGCCAGTACAAATAG | |
| Apta_912 | DNA | TAGTATGGACTTGTCTTCTTGTCAGAGTCTGGCAGCACGT | |
| Apta_694 | DNA | ACTCACTATGGAAGAGATGGCGACATCTCTTCTCCGAGCCGGTCGAAATAGTGAGT | |
| Apta_451 | DNA | ATACCAGCTTATTCAATTGAGTAAGAGTGCACTATGTTTTACGAGCCGTTTCCTCGGCAGATAGTAAGTGCAATCT | |
| Apta_796 | DNA | GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG | |
| Apta_57 | DNA | GCGGGTCGGTTGCTCGCTTCGCCCGATCGGTCTAAGGGTG | |
| Apta_163 | DNA | GCGCATGACCATTGATGTCTGCACCATCAGAGGCAGAG | |
| Apta_259 | DNA | GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT | |
| Apta_260 | DNA | GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT | |
| Apta_273 | DNA | ATAAGCTGAGCATCTTAGATCCCCGTCAAGGGCAGCGTAA | |
| Apta_274 | DNA | GATACTGAGCATCGTACATGATCCCGCAACGGGCAGTATT | |
| Apta_449 | DNA | CGCACTATGTTTTACGAGCCGTTTCCTCGGCAGATAGTAAGTGCG | |
| Apta_476 | DNA | CCTATCTTATTCGTTGCGGACTCCCCGGTCGGTATGTATG | |
| Apta_776 | DNA | AGTGGTCGAACTACACATCCTTGAACTGCGGAATTATCTAC | |
| Apta_778 | DNA | GAAGACGAGCGGCGAGTGTTATTACGCTTGGAAACAACCCC |
DEV TOOL
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