AptaDB: Result

Interaction ID: 505

Aptamer sequence: UGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG

Target unique ID: Q9H6S3

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_426	E07	Protein	ES8L2_HUMAN	2.4 nM	1X DPBS, 5 mM MgCl2, pH 7.1-7.5	21687663

Aptamer Sequence:	UGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
The optimal secondary structure in dot-bracket notation:	....(((...((((((((.........))))......)))).....)))..
The centroid secondary structure in dot-bracket notation:	....(((...((((((((.........))))......)))).....)))..

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_426	Description	E07
Aptamer chemistry	RNA	Length	51 nt
GC content	47.1%	Molecular weight	16,377.80 Da
Molarity of 1 μg/μl solution	61.06 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	UGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
Applications	Be used to escort other anti-tumor or contrast agents

Type	Detail	Type	Detail
Uniprot ID	Q9H6S3	Protein name	Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Gene name(s)	EPS8L2 EPS8R2 PP13181	Organism	Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Status	reviewed in uniprot database	Length	715
Mass	80,621	Activity regulation	N/A
Involvement in disease	Deafness, autosomal recessive, 106 (DFNB106)	Catalytic activity	N/A
PDB ID(s)	1WWU;1WXB;
Function	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.

	Interaction ID	432
	Target type	Protein
	Target unique ID	Q01279
	Activity	36 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663
	Interaction ID	505
	Target type	Protein
	Target unique ID	Q9H6S3
	Activity	2.4 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_425	RNA	UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	92.16%
Apta_424	RNA	UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	90.20%
Apta_92	RNA	ACAACUUAAUGCGACGUUGGUAAAGCAUAUCAAAC	56.86%
Apta_304	RNA	CGGCCGAUAGAAAGACUACUUGAGCCCUUAAAUGAGGUUAUGUGCGGCCG	54.90%
Apta_707	RNA	GGCCUAAAACAUACCAGAUUUCGAUCUGGAGAGGUGAAGAAUUCGACCACCUAGGCCGGU	51.67%
Apta_53	RNA	UCCCUGGCCCAAGAUCCUAAUAAAGUUUUUUCGGACCGGAGCGAAACCACUAUCCUCUUAAGCAAUCUGU	51.43%
Apta_296	RNA	AUACCAGCUUAUUCAAUUGCCUGAAAACCUGGUCUCUCUGUCAGCAAAGACUAUGTUGAGAUAGUAAGUGCAAUCU	51.32%
Apta_51	RNA	GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC	50.98%
Apta_93	RNA	CUCCGCUAUCUAACGUAUGAUAGAAUGGAUGACUA	50.98%
Apta_658	RNA	CUGCGAUCAGGGGUAAAUUUCCGCGCAGGCUCCACGCCGC	50.98%
Apta_703	RNA	GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG	50.98%
Apta_716	RNA	GGCGCUUCAUGCCGAAAGGCCCGUUGUAACGUC	50.98%
Apta_758	RNA	GGCUUUCGGGCUUUCGGCAACAUCAGCCCCUCAGCC	50.98%
Apta_848	RNA	CACCACGAUCACGGUUUCCCUCGCAGGUAAGGUGUAGA	50.98%
Apta_849	RNA	UCCCGAUUACUGUACAUACCUUAGCCCAUAGCUGGCUGC	50.98%
Apta_301	RNA	AUACCAGCUUAUUCAAUUGCCUGAAAAGUUGAACUCCAAAUACGCGCUGAGAUAGUAAGUGCAAUCU	50.75%
Apta_383	RNA	GGCGUGACCUGAUGAGUCACGCUAAGGAGGAUUUCCGAAAGCGGCUACGGUCCGCCAGUGUUACGAAACGUUCCC	50.67%
Apta_696	RNA	GAGUGCGCCCAUUGAUAAGAGCGUAGGUUCAACGGAGUCGUAGUCGUUCUCAAGUUGACGGUGCAUUAGAGUCCU	50.67%
Apta_299	RNA	AUACCAGCUUAUUCAAUUGCCUGAAGACUGGAUAUACUCUUAAGCAUUUCUAUAAUCGAGAUAGUAAGUGCAAUCU	50.00%
Apta_300	RNA	AUACCAGCUUAUUCAAUUGCCUGAAACUGCUGCAUCGUCUCCCACGUAUUACACAUGAAGAUAGUAAGUGCAAUCU	50.00%

ABOUT