Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 102
Aptamer sequence: AGCAGCACAGAGGTCAGATGTGTTAGGCTGGGACACGTATTACACTTACCGTAAATATTTCCTATGCGTGCTACCGTGAA
Target unique ID: P01298
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_101 4.13 Protein PAHO_HUMAN 12 μM 20 mM Hepes (pH 7.3) with 10 mM NaCl 15984861
Structure information of aptamer
Aptamer Sequence: AGCAGCACAGAGGTCAGATGTGTTAGGCTGGGACACGTATTACACTTACCGTAAATATTTCCTATGCGTGCTACCGTGAA
The optimal secondary structure in dot-bracket notation: (((((((((.........))))))..)))((..(((((((.......................)))))))...)).....
The centroid secondary structure in dot-bracket notation: ....(((((.........)))))..........((((((.........................))))))..........
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_101 Description 4.13
Aptamer chemistry DNA Length 80 nt
GC content 46.3% Molecular weight 24,956.79 Da
Molarity of 1 μg/μl solution 40.07 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence AGCAGCACAGAGGTCAGATGTGTTAGGCTGGGACACGTATTACACTTACCGTAAATATTTCCTATGCGTGCTACCGTGAA
Applications Binding to target proteins
Target information
Type Detail Type Detail
Uniprot ID P01298 Protein name Pancreatic prohormone (Pancreatic polypeptide) (PP) (Obinepitide) [Cleaved into: Pancreatic hormone (PH); Pancreatic icosapeptide (PI)]
Gene name(s) PPY PNP Organism Pancreatic prohormone (Pancreatic polypeptide) (PP) (Obinepitide) [Cleaved into: Pancreatic hormone (PH); Pancreatic icosapeptide (PI)]
Status reviewed in uniprot database Length 95
Mass 10,445 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
1TZ4;1TZ5;
Function Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
Activity data

No relevant experimental diagram

 Interaction ID 102
Target type Protein
Target unique ID P01298
Activity 12 μM
Binding Conditions/Buffer

20 mM Hepes (pH 7.3) with 10 mM NaCl
Assay

N/A
PubMed ID 15984861

No relevant experimental diagram

 Interaction ID 115
Target type Protein
Target unique ID P01303
Activity 1.0 μM
Binding Conditions/Buffer

20 mM Hepes (pH 7.3) with 10 mM NaCl
Assay

N/A
PubMed ID 15984861
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_101 DNA AGCAGCACAGAGGTCAGATGTGTTAGGCTGGGACACGTATTACACTTACCGTAAATATTTCCTATGCGTGCTACCGTGAA
100.00%
Apta_99 DNA AGCAGCACAGAGGTCAGATGTCGGGCGGTTCGGGACCTTGCTGCGACATATGCGTATTATCCTATGCGTGCTACCGTGAA 76.25%
Apta_108 DNA AGCAGCACAGAGGTCAGATGCTTTGCCACGGCAACGTCCCAAAACTAATGGTAACTATACCCTATGCGTGCTACCGTGAA 76.25%
Apta_99 DNA AGCAGCACAGAGGTCAGATGTCGGGCGGTTCGGGACCTTGCTGCGACATATGCGTATTATCCTATGCGTGCTACCGTGAA 76.25%
Apta_108 DNA AGCAGCACAGAGGTCAGATGCTTTGCCACGGCAACGTCCCAAAACTAATGGTAACTATACCCTATGCGTGCTACCGTGAA 76.25%
Apta_178 DNA AGCAGCACAGAGGTCAGATGCGGTATGCTGGGTCATCTAACTGGGGATATTCTGATATTGCCTATGCGTGCTACCGTGAA 76.25%
Apta_235 DNA AGCAGCACAGAGGTCAGATGTGGTTCGATGCTGCAAGGTGTTGTCATTTGGCATATGTTACCTATGCGTGCTACCGTGAA 76.25%
Apta_107 DNA AGCAGCACAGAGGTCAGATGTTCATTTCAGTTGACCGATAGCATTGAGCAATGATCTATTCCTATGCGTGCTACCGTGAA 73.75%
Apta_110 DNA AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA 73.75%
Apta_107 DNA AGCAGCACAGAGGTCAGATGTTCATTTCAGTTGACCGATAGCATTGAGCAATGATCTATTCCTATGCGTGCTACCGTGAA 73.75%
Apta_110 DNA AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA 73.75%
Apta_175 DNA AGCAGCACAGAGGTCAGATGAGGACTGTCGATAAGTATAATGGCAAGTAGCTCGATACATCCTATGCGTGCTACCGTGAA 73.75%
Apta_102 DNA AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA 72.50%
Apta_102 DNA AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA 72.50%
Apta_232 DNA AGCAGCACAGAGGTCAGATGCTATGAGCAGATCCGATAGAAAGTTAATGCCCTAGAACATCCTATGCGTGCTACCGTGAA 72.50%
Apta_173 DNA AGCAGCACAGAGGTCAGATGGCAGGTTTCGACGTACAATGCTATGGAGGCTTTATGATCGCCTATGCGTGCTACCGTGAA 71.25%
Apta_233 DNA AGCAGCACAGAGGTCAGATGTGAAACATAGCATATTTACTTATGTCGCCTTGCCGGTTCCTATGCGTGCTACCGTGAA 71.25%
Apta_236 DNA AGCAGCACAGAGGTCAGATGAGATGGTTGACCGGTTGATGTGATTAAGGAGACGTCGATTCCTATGCGTGCTACCGTGAA 71.25%
Apta_103 DNA AGCAGCACAGAGGTCAGATGCATCGCATTATTCGCGGCCGGCCAACGAGAGTATGTTTCTCCTATGCGTGCTACCGTGAA 70.00%
Apta_105 DNA AGCAGCACAGAGGTCAGATGATGCTCTAGGCGAAAGACTTGGCGTAGAACGACGGGAGGCCCTATGCGTGCTACCGTGAA 70.00%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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