AptaDB: Result

Interaction ID: 431

Aptamer sequence: UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG

Target unique ID: Q01279

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_425	E04	Protein	EGFR_MOUSE	48 nM	1X DPBS, 5 mM MgCl2, pH 7.1-7.5	21687663

Aptamer Sequence:	UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
The optimal secondary structure in dot-bracket notation:	....((....((..((((.........)))).))...))............
The centroid secondary structure in dot-bracket notation:	..............((((.........))))....................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_425	Description	E04
Aptamer chemistry	RNA	Length	51 nt
GC content	49.0%	Molecular weight	16,336.79 Da
Molarity of 1 μg/μl solution	61.21 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
Applications	Be used to escort other anti-tumor or contrast agents

Type	Detail	Type	Detail
Uniprot ID	Q01279	Protein name	Epidermal growth factor receptor (EC 2.7.10.1)
Gene name(s)	Egfr	Organism	Epidermal growth factor receptor (EC 2.7.10.1)
Status	reviewed in uniprot database	Length	1210
Mass	134,853	Activity regulation	Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms
Involvement in disease	N/A	Catalytic activity	Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
PDB ID(s)	N/A
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.

	Interaction ID	431
	Target type	Protein
	Target unique ID	Q01279
	Activity	48 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663
	Interaction ID	507
	Target type	Protein
	Target unique ID	Q9H6S3
	Activity	2.6 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_426	RNA	UGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	92.16%
Apta_424	RNA	UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	90.20%
Apta_1228	DNA	GGCCACCAAACCACACCGTCGCAACCGCGAGAACCGAAGTAGTGATCATGTCCCTGCGTG	53.33%
Apta_92	RNA	ACAACUUAAUGCGACGUUGGUAAAGCAUAUCAAAC	52.94%
Apta_303	RNA	CCUCCGGCUCAUACCUUUUCGAAGACAAGCUUCGACAGGAGG	52.94%
Apta_53	RNA	UCCCUGGCCCAAGAUCCUAAUAAAGUUUUUUCGGACCGGAGCGAAACCACUAUCCUCUUAAGCAAUCUGU	52.86%
Apta_383	RNA	GGCGUGACCUGAUGAGUCACGCUAAGGAGGAUUUCCGAAAGCGGCUACGGUCCGCCAGUGUUACGAAACGUUCCC	52.00%
Apta_707	RNA	GGCCUAAAACAUACCAGAUUUCGAUCUGGAGAGGUGAAGAAUUCGACCACCUAGGCCGGU	51.67%
Apta_93	RNA	CUCCGCUAUCUAACGUAUGAUAGAAUGGAUGACUA	50.98%
Apta_304	RNA	CGGCCGAUAGAAAGACUACUUGAGCCCUUAAAUGAGGUUAUGUGCGGCCG	50.98%
Apta_313	RNA	UGCCCUGCCCUCACCCGUUAGCCUGAGCGCCCCGCA	50.98%
Apta_658	RNA	CUGCGAUCAGGGGUAAAUUUCCGCGCAGGCUCCACGCCGC	50.98%
Apta_848	RNA	CACCACGAUCACGGUUUCCCUCGCAGGUAAGGUGUAGA	50.98%
Apta_1248	RNA	GGGUGACUUUUCCCUCAGGCUCCUGUGAAGCAACCGAAUGGACUGAAAUGAAACCGCCC	50.85%
Apta_696	RNA	GAGUGCGCCCAUUGAUAAGAGCGUAGGUUCAACGGAGUCGUAGUCGUUCUCAAGUUGACGGUGCAUUAGAGUCCU	49.33%
Apta_447	RNA	ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC	49.12%
Apta_51	RNA	GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC	49.02%
Apta_85	RNA	UGCGACUGUUAUAACCUAACAGCGACGUAAAGAUA	49.02%
Apta_88	RNA	AAUAACCUUAAUGCGACGUUGGUUUGUCAACAACG	49.02%
Apta_257	DNA	GGCAGAAGAAATATCGAAACCCAGAATGGTCGGCCAGGCG	49.02%

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