Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1282
Aptamer sequence: TGGCGACAAGAAGACGTACAAACACGCACCAGGCCGGAGTGGAGTATTCTGAGGTCGG
Target unique ID: 431734
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1220 ATX8 Molecule Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1R)- 81.3 nM 50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM MgCl2 25594161
Structure information of aptamer
Aptamer Sequence: TGGCGACAAGAAGACGTACAAACACGCACCAGGCCGGAGTGGAGTATTCTGAGGTCGG
The optimal secondary structure in dot-bracket notation: ...((((....(((.((((...(((...((.....)).)))..)))))))...)))).
The centroid secondary structure in dot-bracket notation: ...((((....(((.((((...(((...((.....)).)))..)))))))...)))).
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1220 Description ATX8
Aptamer chemistry DNA Length 58 nt
GC content 56.9% Molecular weight 18,039.58 Da
Molarity of 1 μg/μl solution 55.43 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence TGGCGACAAGAAGACGTACAAACACGCACCAGGCCGGAGTGGAGTATTCTGAGGTCGG
Applications Aptasensor for neurotoxin anatoxin-a
Target information
Type Detail Type Detail
PubChem ID 431734 Molecular name Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1R)-
Molecular formula C10H15NO Molecular weight 165.23
IUPAC name 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)ethanone InChIKey SGNXVBOIDPPRJJ-UHFFFAOYSA-N
LogP 1.416 Topological polar surface area 29.1
Hydrogen bond acceptor 2 Hydrogen bond donor 1

Synonym(s):
Anatoxin A; Anatoxin-a; (+)-Anatoxin; CHEMBL25619; CHEBI:2706; Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1R)-; 2-acetyl-9-azabicyclo[4.2.1]non-2-ene; 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)ethanone; AC1L8S0X; Anatoxin-A,(+); SureCN160708; 1-(9-azabicyclo[4.2.1]non-4-en-5-yl)ethanone; SCHEMBL160708; BDBM50023330; NCGC00162392-01; NCGC00162392-02; 2-Acetyl-9-azabicyclo[4.2.1]nona-2-ene; 2-acetyl-9-azabicyclo [4.2.1]non-2-ene; 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-ethanone; Q3303006; 1-(9-Aza-bicyclo[4.2.1]non-2-en-2-yl)-ethanone; (+/-)-2-ACETYL-9-AZABICYCLO[4.2.1]NON-2-ENEFUMARATE

Activity data

No relevant experimental diagram

 Interaction ID 1282
Target type Molecule
Target unique ID 431734
Activity 81.3 nM
Binding Conditions/Buffer

50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM MgCl2
Assay

N/A
PubMed ID 25594161
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_1068 DNA CGGGACAAGACAACGAACGAACAGGAAGAGAACCGGAATGCAGACGTCAGGG 62.07%
Apta_688 DNA GCCATGACAACCAGAGGTACCCCCGCCCACCAGCCCCGAAGTCTGTCAGCCTAGTTGTTG 56.67%
Apta_1213 DNA GGACTTGAAGAAAAGGGCGACACGCGAAGTCGATGTCGCGTCTGCCTGAAGTCA 55.17%
Apta_1267 DNA GGCACGGCAAAGGGGTACAGCCTACCGAACCGTGGCTGTAAGGGTGGTTGTGGTGTG 55.17%
Apta_742 DNA ATCGTCTGCTCCGTCCAATAGGACCGATAGGAACCACGGACTGCATGTTTCTGCATTTGACGTGGTTTGGTGTGAGGTCGTGC 54.22%
Apta_418 DNA TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT 54.17%
Apta_257 DNA GGCAGAAGAAATATCGAAACCCAGAATGGTCGGCCAGGCG 53.45%
Apta_744 DNA GTGGCCAGTCACTCAATTGGGTGTAGGGGTGGGGATTGTGGGTTG 53.45%
Apta_755 DNA GGGGAGGGAGACACAGTCATGGAGCAGTTATTAGGGTGTACCGGGTGTAGT 53.45%
Apta_663 DNA CACGCACAGAAGACACCTACAGGGCCAGATCACAATCGGTTAGTGAACTCGTACGGCGCG 53.33%
Apta_888 DNA GGCGACCCCCGGGCTACCAGACAATGTACGCAGCAAGAGTGACGGTCGTACCTCGGAGTC 53.33%
Apta_109 DNA AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA 53.16%
Apta_109 DNA AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA 53.16%
Apta_417 DNA GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT 52.78%
Apta_501 DNA GGGAGACAAGAATAAACGCTCAATTTAACGTATTTATTCAAGCTCGTATTCGACAGGAGGCTCACAACAGGC 52.78%
Apta_898 DNA ATACGGGAGCCAACACCAACAAAACTAGCAAATTAGAGCCGTATCGGAGCCTATAGAGCAGGTGTGACGGAT 52.78%
Apta_685 DNA GGGGCAACAAACACGGAAGAAAATGAATCTACATACGTGGACATATATCCTGCCGCGTG 52.54%
Apta_687 DNA GGGACAGCGGAGGTCTCCCACCCACCGGCCCCTGCGGCACACCAACCTGTATGGATGCG 52.54%
Apta_838 DNA TGAGCCCAAGCCCTGGTATGTAGTAATGGTGCGTACAGGCGACGGGGTCCAGGCTGGAGGGGCAGGTCTACTTTGGGATC 52.50%
Apta_800 DNA AAGGAGCAGCGTGGAGGATATACACCGTCATCAGAGGGAGCATCTCTAGTCAGGACTGTGATGAATTAGGGTGTGTCGTCGTGGT 51.76%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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