Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1289
Aptamer sequence: CACACCAAACACACAAGTGGACCCTGACGCATGGATAGGGTGACGGTATACGCGGGCATG
Target unique ID: 5353447
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1227 BT 1 Molecule Brevetoxin 2 385 nM 50 mM Tris, pH 7.5, and 10 mM MgCl2 25725463
Structure information of aptamer
Aptamer Sequence: CACACCAAACACACAAGTGGACCCTGACGCATGGATAGGGTGACGGTATACGCGGGCATG
The optimal secondary structure in dot-bracket notation: ....((...(((....))).((((((.........))))))..((.....)).)).....
The centroid secondary structure in dot-bracket notation: .........(((....))).((((((.........))))))...(.....).........
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1227 Description BT 1
Aptamer chemistry DNA Length 60 nt
GC content 56.7% Molecular weight 18,561.92 Da
Molarity of 1 μg/μl solution 53.87 μM Number of G-quadruplexes 2
G-Score 19 Function Aptasensor
Sequence CACACCAAACACACAAGTGGACCCTGACGCATGGATAGGGTGACGGTATACGCGGGCATG
Applications Detection of BTX-2 in food samples
Target information
Type Detail Type Detail
PubChem ID 5353447 Molecular name Brevetoxin 2
Molecular formula C50H70O14 Molecular weight 895.1
IUPAC name 2-[[(21Z)-12-hydroxy-1,3,11,24,31,41,44-heptamethyl-39-oxo-2,6,10,15,19,25,29,34,38,43,47-undecaoxaundecacyclo[26.22.0.03,26.05,24.07,20.09,18.011,16.030,48.033,46.035,44.037,42]pentaconta-21,40-dien-14-yl]methyl]prop-2-enal InChIKey LYTCVQQGCSNFJU-KTKRTIGZSA-N
LogP 5.472 Topological polar surface area 155.9
Hydrogen bond acceptor 14 Hydrogen bond donor 1

Synonym(s):
Brevetoxin 2; brevetoxin pbtx-2; 79580-28-2; Brevetoxin T 34; 2-[[(21Z)-12-hydroxy-1,3,11,24,31,41,44-heptamethyl-39-oxo-2,6,10,15,19,25,29,34,38,43,47-undecaoxaundecacyclo[26.22.0.03,26.05,24.07,20.09,18.011,16.030,48.033,46.035,44.037,42]pentaconta-21,40-dien-14-yl]methyl]prop-2-enal; Brevetoxin PbTx 2; GB 2 toxin; T-34 toxin; GB 2 (Gymnodinium); Toxin T-34; T 4-7 toxin; Ptychodiscus brevis toxin 2; GB 2; T 4-7

Activity data

No relevant experimental diagram

 Interaction ID 1289
Target type Molecule
Target unique ID 5353447
Activity 385 nM
Binding Conditions/Buffer

50 mM Tris, pH 7.5, and 10 mM MgCl2
Assay

N/A
PubMed ID 25725463
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_686 DNA GGTCACCAACAACAGGGAGCGCTACGCGAAGGGTCAATGTGACGTCATGCGGATGTGTGG 58.33%
Apta_1218 DNA CGACACCACACAGCAGTAAGCACTACAACATAGTGGTCTAGACTATCTCGGGCCGGTG 58.33%
Apta_618 DNA GCGGCAAATCAGCATACGAGTGTACAGGGACGGGACGGGTGGGTAAAAGGTGTCGCCTCAG 55.74%
Apta_109 DNA AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA 55.70%
Apta_109 DNA AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA 55.70%
Apta_578 DNA CACCAAGCGCAGGGAATTACATTGAAGTGTGGGATTGGCT 55.00%
Apta_663 DNA CACGCACAGAAGACACCTACAGGGCCAGATCACAATCGGTTAGTGAACTCGTACGGCGCG 55.00%
Apta_1047 DNA TAGTCCCAAGGCACATAAGGGCCGGAGGTCTAGCGTCAGGGATACAGAGA 55.00%
Apta_1228 DNA GGCCACCAAACCACACCGTCGCAACCGCGAGAACCGAAGTAGTGATCATGTCCCTGCGTG 55.00%
Apta_31 DNA ATACCAGTCTATTCAATTGGGCCCGTCCGTATGGTGGGTGTGCTGGCCAGATAGTATGTGCAATCA 54.55%
Apta_417 DNA GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT 54.17%
Apta_664 DNA CACGCAACAACACAACATGCCCAGCGCCTGGAACATATCCTATGAGTTAGTCCGCCCACA 53.33%
Apta_730 DNA ACCAAACACAGATGCAACCTGACTTCTAACGTCATTTGGTG 53.33%
Apta_834 DNA CGCAATACCAAAGTGGCGAGAGCGCTGTCTTGAGTGAGTGGTTGG 53.33%
Apta_868 DNA CCCAGAAACAGCACCCTTACATCGACTGGACCTTCCGCG 53.33%
Apta_888 DNA GGCGACCCCCGGGCTACCAGACAATGTACGCAGCAAGAGTGACGGTCGTACCTCGGAGTC 53.33%
Apta_1069 DNA CCGGAGAAAAAAAACTTGATGAGCCAGGAAAACGAGGGTTGGAACGCGACTG 53.33%
Apta_1265 DNA CACGCACACAACAGCCAATAATGTATAACGCTGTCCACTGTGTGGTGTCCCCCGCGTCG 53.33%
Apta_1117 DNA CGTACGGAATTCGCTAGCGGACTGGAGTCTAGACCGGGTAGCTGTGGTGGATCCGAGCTCCACGTG 53.03%
Apta_418 DNA TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT 52.78%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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