Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1047
Aptamer sequence: CACGAGAGGGGTGAGGTGTCGTATTAGAGGGAAGCTCCAA
Target unique ID: P01266
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_964 | T-7 | Protein | THYG_HUMAN | 5.88 μM | TGK, Tris-HCl, BBS, and PBS | 33303143 |
Structure information of aptamer
| Aptamer Sequence: | CACGAGAGGGGTGAGGTGTCGTATTAGAGGGAAGCTCCAA |
| The optimal secondary structure in dot-bracket notation: | .......(((((......((......)).....))))).. |
| The centroid secondary structure in dot-bracket notation: | .......(((((......((......)).....))))).. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_964 | Description | T-7 |
| Aptamer chemistry | DNA | Length | 40 nt |
| GC content | 55.0% | Molecular weight | 12,515.05 Da |
| Molarity of 1 μg/μl solution | 79.90 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | CACGAGAGGGGTGAGGTGTCGTATTAGAGGGAAGCTCCAA | ||
| Applications | CE-based detection validated the application feasibility of aptamer for Tg detection | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P01266 | Protein name | Thyroglobulin (Tg) |
| Gene name(s) | TG | Organism | Thyroglobulin (Tg) |
| Status | reviewed in uniprot database | Length | 2768 |
| Mass | 304,790 | Activity regulation | N/A |
| Involvement in disease | Thyroid dyshormonogenesis 3 (TDH3) | Catalytic activity | N/A |
| PDB ID(s) | 6SCJ;7B75; |
 |
Function | Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). |
Activity data
|
No relevant experimental diagram |
Interaction ID | 1047 |
| Target type | Protein | |
| Target unique ID | P01266 | |
| Activity | 5.88 μM | |
| Binding Conditions/Buffer | TGK, Tris-HCl, BBS, and PBS |
|
| Assay | N/A |
|
| PubMed ID | 33303143 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_1256 | DNA | GATCGGGTGTGGGTGGCGTAAAGGGAGCATCGGACA | |
| Apta_1081 | DNA | CTTACGACTGTGGTCGGGTGGTGGGCCTCTAGAGGGGTGTCGTAAG | |
| Apta_778 | DNA | GAAGACGAGCGGCGAGTGTTATTACGCTTGGAAACAACCCC | |
| Apta_778 | DNA | GAAGACGAGCGGCGAGTGTTATTACGCTTGGAAACAACCCC | |
| Apta_30 | DNA | AGAGGGGGGGGTGGAGGGGGCTAGA | |
| Apta_1188 | DNA | CGGGCGGGGCGTGGGGTGTTGGAGTGGAGGGCGGGGCGGC | |
| Apta_69 | DNA | AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT | |
| Apta_71 | DNA | GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC | |
| Apta_73 | DNA | GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC | |
| Apta_74 | DNA | GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC | |
| Apta_181 | DNA | CCGTGTAAGGTTTCAGTGGCTTATCCGAAGTAACCCGAGA | |
| Apta_438 | DNA | AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_438 | DNA | AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_445 | DNA | AGCCATGACGATGTCGTTACGTAGATGTAGAGACTCCTAA | |
| Apta_446 | DNA | AGCCATGACGATGTCGTTACGTAGATGCATAGACTCCTAA | |
| Apta_831 | DNA | CCGCCCAGCGGGGGTAGGGCCGGACGTAGGAGGAGCTGCG | |
| Apta_850 | DNA | CACCAGTGTGTTGAGGTTTGAGCACACTGATAGAGTGTCA | |
| Apta_1093 | DNA | AGGAGGGTAGGTAGTGCTTGGTAGGGAAACTCCGCCGATT | |
| Apta_1095 | DNA | CCCTGAGGGGTGATGTGAATCCTAACAGTAAGGAGGAAGG | |
| Apta_344 | DNA | CACTACAGAGGTTGCGTCTGTCCCACGTTGTCATGGGGGGTTGGCCTG |
DEV TOOL
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