Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1198
Aptamer sequence: AATAGGGTAAAAAAAAAAAGTTGGTCCTATG
Target unique ID: 54680783
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1139 A04T.2 Molecule Citrinin 3918 nM 20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl 30085205
Structure information of aptamer
Aptamer Sequence: AATAGGGTAAAAAAAAAAAGTTGGTCCTATG
The optimal secondary structure in dot-bracket notation: .((((((.................)))))).
The centroid secondary structure in dot-bracket notation: .((((((.................)))))).
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1139 Description A04T.2
Aptamer chemistry DNA Length 31 nt
GC content 29.0% Molecular weight 9,648.29 Da
Molarity of 1 μg/μl solution 103.65 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence AATAGGGTAAAAAAAAAAAGTTGGTCCTATG
Applications Binding to targets
Target information
Type Detail Type Detail
PubChem ID 54680783 Molecular name Citrinin
Molecular formula C13H14O5 Molecular weight 250.25
IUPAC name (3R,4S)-6-hydroxy-3,4,5-trimethyl-8-oxo-3,4-dihydroisochromene-7-carboxylic acid InChIKey CBGDIJWINPWWJW-IYSWYEEDSA-N
LogP 1.721 Topological polar surface area 83.8
Hydrogen bond acceptor 5 Hydrogen bond donor 2

Synonym(s):
citrinin; 518-75-2; (-)-citrinin; Citriain; (3R,4S)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid; UNII-3S697X6SNZ; NSC186; 4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid; 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-; 3S697X6SNZ; CHEBI:48707; MFCD00006912; (3R,4S)-6-hydroxy-3,4,5-trimethyl-8-oxo-3,4-dihydroisochromene-7-carboxylic acid; (3R,4S)-8-hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid; (3R-trans)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid; (3R,4S)-8-hydroxy-3,4,5-trimethyl-6-oxo-3,4-dihydroisochromene-7-carboxylic acid; CCRIS 175; HSDB 3473; EINECS 208-257-2; BRN 0088597; NSC-186; 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-; 3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxobenzo(c)pyran-7-carboxylic acid; Citrinin, 98%; Spectrum_000451; Spectrum2_000734; Spectrum3_000240; Spectrum4_001804; Spectrum5_000507; BSPBio_001919; KBioGR_002411; KBioSS_000931; SPECTRUM210186; 5-18-09-00061 (Beilstein Handbook Reference); DivK1c_000646; SCHEMBL157775; SPBio_000688; DTXSID8020333; HMS502A08; KBio1_000646; KBio2_000931; KBio2_003499; KBio2_006067; KBio3_001419; NINDS_000646; HMS1923C05; CCG-39048; ZINC19795941; AKOS030254668; SDCCGMLS-0066537.P001; Citrinin 100 microg/mL in Acetonitrile; IDI1_000646; NCGC00160164-01; NCGC00160164-02; NCGC00160164-03; NCI60_001544; E80637; Q420354; SR-05000002496; WLN: T66 CO HV AUT&J D1 E1 G1 IVQ JQ; SR-05000002496-1; Citrinin, from Penicillium citrinum, >=98% (HPLC); Q63392265; Citrinin solution, 100 mug/mL in acetonitrile, analytical standard; (3R,4S)-3,4,5-Trimethyl-6-hydroxy-8-oxo-4,8-dihydro-3H-2-benzopyran-7-carboxylic acid; 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-; 8-Hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid #; 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-,(3R,4S)-; 3H-2-Benzopyran-7-carboxylic acid,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-; 4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo, (3R-trans)-3H-2-benzopyran-7-carboxylic acid

Activity data
Interaction ID 1195
Target type Molecule
Target unique ID 442530
Activity 71 nM
Binding Conditions/Buffer

20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl
Assay

Binding isotherms for aptamer
PubMed ID 30085205
Interaction ID 1196
Target type Molecule
Target unique ID 20966
Activity 71 μM
Binding Conditions/Buffer

20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl
Assay

Binding isotherms for aptamer
PubMed ID 30085205
Interaction ID 1197
Target type Molecule
Target unique ID 54678486
Activity 1492 nM
Binding Conditions/Buffer

20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl
Assay

Binding isotherms for aptamer
PubMed ID 30085205
Interaction ID 1198
Target type Molecule
Target unique ID 54680783
Activity 3918 nM
Binding Conditions/Buffer

20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl
Assay

Binding isotherms for aptamer
PubMed ID 30085205
Interaction ID 1199
Target type Molecule
Target unique ID 186907
Activity 33 μM
Binding Conditions/Buffer

20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl
Assay

Binding isotherms for aptamer
PubMed ID 30085205
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_419 DNA ATCAGGGCTAAAGAGTGCAGAGTTACTTAG 54.84%
Apta_1152 DNA GACAAGGATAAATCCTTCAATGAAGTGGGTCACTCATCTGTGA 53.49%
Apta_929 DNA GAGTGGGATGGATAGAGAATAAGTGTGGAGTGGAAGGTGA 52.50%
Apta_343 DNA AACAGAGGGACAAACGGGGGAAGATTTGACGTCGACGAC 51.28%
Apta_847 DNA CACTAGGATCTAGGGAAAAATCTCGTAAATACTATACTCCTGAGC 51.11%
Apta_261 DNA TAAACCCCAAAACAGTGCAACTAGGTGTAGGTCCCGTGGT 50.00%
Apta_512 DNA ATAGGACGATTATCGAAAATCACCAGATTGGACCCTGGTTAACGAT 50.00%
Apta_580 DNA ATGCGGGTATATGGTGCGAGAAAACAAGGGGCATACTGGA 50.00%
Apta_783 DNA AAGGGGTTGGGTGGGTTTATACAAATTAATTAATATTGTATGGTATATTT 50.00%
Apta_876 DNA GTTGCGAAAGACAACGAATGCTTTGCCTGCCATAATTTGC 50.00%
Apta_946 DNA TACCGGGTAATATGCACACATGCTGATAGCAAGCAATGCA 50.00%
Apta_977 DNA CAATCTGCTAAAACTTAAAGCCTATTAATGAAATTGTTAAGGTGGTATCC 50.00%
Apta_1286 DNA CTATACGTATTCTAACTTGTTACGTATTGGTCTCTTATTG 50.00%
Apta_639 DNA CTAAGCACAGGGAAACCAGCTAATGAGTTAGGCCTGTCCCCCACG 48.89%
Apta_640 DNA CAATGGACCTATTCGAGTACTGAATAGAACAGTCGGCGCTCTGGG 48.89%
Apta_158 DNA CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTG 48.72%
Apta_347 DNA AAAAAAAAAAAAGTACGTTCAGGAGCAGTGCGA 48.48%
Apta_213 DNA AGGAAGGCAAAAGGAAAAAAAAAAAGGAAA 48.39%
Apta_330 DNA GCTGGGTAAATAGATGATTCCCGGC 48.39%
Apta_514 DNA ACTCAGCACGCGTGTAGGGAAAACCAACCGCCCACAAGCTGCATGCAACG 48.00%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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