Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 107
Aptamer sequence: AGCAGCACAGAGGTCAGATGGAGCCAGGAGTCGGCCTACAGAAGATTCTGATGTACCTCACCTATGCGTGCTACCGTGAA
Target unique ID: P01298
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_106 | 6.11 | Protein | PAHO_HUMAN | 7 μM | 20 mM Hepes (pH 7.3) with 10 mM NaCl | 15984861 |
Structure information of aptamer
| Aptamer Sequence: | AGCAGCACAGAGGTCAGATGGAGCCAGGAGTCGGCCTACAGAAGATTCTGATGTACCTCACCTATGCGTGCTACCGTGAA |
| The optimal secondary structure in dot-bracket notation: | (((((((...((((..((.((.((..((((((...........))))))...)).)))))))).))).))))........ |
| The centroid secondary structure in dot-bracket notation: | (((((((...((((................((...........))..............)))).))).))))........ |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_106 | Description | 6.11 |
| Aptamer chemistry | DNA | Length | 80 nt |
| GC content | 53.8% | Molecular weight | 24,986.80 Da |
| Molarity of 1 μg/μl solution | 40.02 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted binding |
| Sequence | AGCAGCACAGAGGTCAGATGGAGCCAGGAGTCGGCCTACAGAAGATTCTGATGTACCTCACCTATGCGTGCTACCGTGAA | ||
| Applications | Binding to target proteins | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P01298 | Protein name | Pancreatic prohormone (Pancreatic polypeptide) (PP) (Obinepitide) [Cleaved into: Pancreatic hormone (PH); Pancreatic icosapeptide (PI)] |
| Gene name(s) | PPY PNP | Organism | Pancreatic prohormone (Pancreatic polypeptide) (PP) (Obinepitide) [Cleaved into: Pancreatic hormone (PH); Pancreatic icosapeptide (PI)] |
| Status | reviewed in uniprot database | Length | 95 |
| Mass | 10,445 | Activity regulation | N/A |
| Involvement in disease | N/A | Catalytic activity | N/A |
| PDB ID(s) | 1TZ4;1TZ5; |
 |
Function | Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. |
Activity data
|
No relevant experimental diagram |
Interaction ID | 107 |
| Target type | Protein | |
| Target unique ID | P01298 | |
| Activity | 7 μM | |
| Binding Conditions/Buffer | 20 mM Hepes (pH 7.3) with 10 mM NaCl |
|
| Assay | N/A |
|
| PubMed ID | 15984861 | |
|
No relevant experimental diagram |
Interaction ID | 119 |
| Target type | Protein | |
| Target unique ID | P01303 | |
| Activity | 9 μM | |
| Binding Conditions/Buffer | 20 mM Hepes (pH 7.3) with 10 mM NaCl |
|
| Assay | N/A |
|
| PubMed ID | 15984861 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_106 | DNA | AGCAGCACAGAGGTCAGATGGAGCCAGGAGTCGGCCTACAGAAGATTCTGATGTACCTCACCTATGCGTGCTACCGTGAA | |
| Apta_61 | DNA | AGCAGCACAGAGGTCAGATGGCAGGTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGCCCTATGCGTGCTACCGTGAA | |
| Apta_228 | DNA | AGCAGCACAGAGGTCAGATGCGGCGCGGGGTCTTTTACAAATAGTTGTCCTAGCCACGCCTATGCGTGCTACCGTGAA | |
| Apta_278 | DNA | AGCAGCACAGAGGTCAGATGAGGCCTGGTGATCGTGCCCAGGCCATATGAGCAAGGAACCCCTATGCGTGCTACCGTGAA | |
| Apta_103 | DNA | AGCAGCACAGAGGTCAGATGCATCGCATTATTCGCGGCCGGCCAACGAGAGTATGTTTCTCCTATGCGTGCTACCGTGAA | |
| Apta_108 | DNA | AGCAGCACAGAGGTCAGATGCTTTGCCACGGCAACGTCCCAAAACTAATGGTAACTATACCCTATGCGTGCTACCGTGAA | |
| Apta_110 | DNA | AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA | |
| Apta_103 | DNA | AGCAGCACAGAGGTCAGATGCATCGCATTATTCGCGGCCGGCCAACGAGAGTATGTTTCTCCTATGCGTGCTACCGTGAA | |
| Apta_108 | DNA | AGCAGCACAGAGGTCAGATGCTTTGCCACGGCAACGTCCCAAAACTAATGGTAACTATACCCTATGCGTGCTACCGTGAA | |
| Apta_110 | DNA | AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA | |
| Apta_173 | DNA | AGCAGCACAGAGGTCAGATGGCAGGTTTCGACGTACAATGCTATGGAGGCTTTATGATCGCCTATGCGTGCTACCGTGAA | |
| Apta_176 | DNA | AGCAGCACAGAGGTCAGATGTATGGTACATTCGAGCGAGCTAAACTAGGATTAAACTCACCCTATGCGTGCTACCGTGAA | |
| Apta_100 | DNA | AGCAGCACAGAGGTCAGATGATTCAAGGGTAACACATCCAGGGGAACGGAATTGCAGCCCCCTATGCGTGCTACCGTGAA | |
| Apta_102 | DNA | AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA | |
| Apta_100 | DNA | AGCAGCACAGAGGTCAGATGATTCAAGGGTAACACATCCAGGGGAACGGAATTGCAGCCCCCTATGCGTGCTACCGTGAA | |
| Apta_102 | DNA | AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA | |
| Apta_177 | DNA | AGCAGCACAGAGGTCAGATGCCATAGGTGCCTGAATTGTCCCAAACATTCGCATGATCGACCTATGCGTGCTACCGTGAA | |
| Apta_178 | DNA | AGCAGCACAGAGGTCAGATGCGGTATGCTGGGTCATCTAACTGGGGATATTCTGATATTGCCTATGCGTGCTACCGTGAA | |
| Apta_232 | DNA | AGCAGCACAGAGGTCAGATGCTATGAGCAGATCCGATAGAAAGTTAATGCCCTAGAACATCCTATGCGTGCTACCGTGAA | |
| Apta_99 | DNA | AGCAGCACAGAGGTCAGATGTCGGGCGGTTCGGGACCTTGCTGCGACATATGCGTATTATCCTATGCGTGCTACCGTGAA |
DEV TOOL
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