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Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-004032
RuRW6
Aliases: Ac-RW6, RuRW6
Normalized sequence
RWRWRW
6 amino acids
Release PepDiana-V1-20260620
48
Activity records
1
Source papers
19
Positive
29
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 32 records
PMC12311667
32 observationsAntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 ON against SA(R) ATCC 43300: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 OFF against SA(R) ATCC 43300: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 ON against SA(S) ATCC 35923: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 OFF against SA(S) ATCC 35923: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 ON against PA(R) ATCC BAA-2108: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 OFF against PA(R) ATCC BAA-2108: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 ON against PA(S) ATCC 27853: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 OFF against PA(S) ATCC 27853: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Ac-RW6 ON against EC(R) ATCC BAA-196: 64
- Measure
- MIC
- Value
- 64 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Ac-RW6 OFF against EC(R) ATCC BAA-196: 64
- Measure
- MIC
- Value
- 64 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 ON against EC(S) ATCC 25922: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 OFF against EC(S) ATCC 25922: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 ON against AB(R) ATCC BAA-1797: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 OFF against AB(R) ATCC BAA-1797: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 ON against AB(S) ATCC 19606: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Ac-RW6 OFF against AB(S) ATCC 19606: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail RuRW6 ON against SA(R) ATCC 43300: 128
- Measure
- MIC
- Value
- 128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail RuRW6 OFF against SA(R) ATCC 43300: 128
- Measure
- MIC
- Value
- 128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 ON against SA(S) ATCC 35923: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 OFF against SA(S) ATCC 35923: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 ON against PA(R) ATCC BAA-2108: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 OFF against PA(R) ATCC BAA-2108: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 ON against PA(S) ATCC 27853: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 OFF against PA(S) ATCC 27853: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail RuRW6 ON against EC(R) ATCC BAA-196: 16 [4.3]
- Measure
- MIC
- Value
- 16 [4.3]
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail RuRW6 OFF against EC(R) ATCC BAA-196: 16 [>6.3]
- Measure
- MIC
- Value
- 16 [>6.3]
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail RuRW6 ON against EC(S) ATCC 25922: 16 [4.3]
- Measure
- MIC
- Value
- 16 [4.3]
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail RuRW6 OFF against EC(S) ATCC 25922: 16 [>6.3]
- Measure
- MIC
- Value
- 16 [>6.3]
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail RuRW6 ON against AB(R) ATCC BAA-1797: 128
- Measure
- MIC
- Value
- 128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 OFF against AB(R) ATCC BAA-1797: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 ON against AB(S) ATCC 19606: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail RuRW6 OFF against AB(S) ATCC 19606: – (denotes MIC >128 μM)
- Measure
- MIC
- Value
- >128 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
Anticancer 16 records
PMC12311667
16 observationsAnticancerCytotoxicNegative / threshold
Record detail Ac-RW6 ON against MCF-10A: – (denotes IC50 >100 μM)
- Measure
- other
- Value
- >100 µM
- Target
- MCF-10A
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Ac-RW6 OFF against MCF-10A: – (denotes IC50 >100 μM)
- Measure
- other
- Value
- >100 µM
- Target
- MCF-10A
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Ac-RW6 ON against MCF-7: – (denotes IC50 >100 μM)
- Measure
- other
- Value
- >100 µM
- Target
- MCF-7
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Ac-RW6 OFF against MCF-7: – (denotes IC50 >100 μM)
- Measure
- other
- Value
- >100 µM
- Target
- MCF-7
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Ac-RW6 ON against MDA-MB-231: – (denotes IC50 >100 μM)
- Measure
- other
- Value
- >100 µM
- Target
- MDA-MB-231
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Ac-RW6 OFF against MDA-MB-231: – (denotes IC50 >100 μM)
- Measure
- other
- Value
- >100 µM
- Target
- MDA-MB-231
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail Ac-RW6 ON against MDA-MB-468: 62.80 ± 5.33
- Measure
- other
- Value
- 62.80 ± 5.33 µM
- Target
- MDA-MB-468
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail Ac-RW6 OFF against MDA-MB-468: 55.34 ± 0.78
- Measure
- other
- Value
- 55.34 ± 0.78 µM
- Target
- MDA-MB-468
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 ON against MCF-10A: 77.67 ± 1.99
- Measure
- other
- Value
- 77.67 ± 1.99 µM
- Target
- MCF-10A
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 OFF against MCF-10A: 82.33 ± 3.91
- Measure
- other
- Value
- 82.33 ± 3.91 µM
- Target
- MCF-10A
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 ON against MCF-7: 75.73 ± 13.96
- Measure
- other
- Value
- 75.73 ± 13.96 µM
- Target
- MCF-7
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 OFF against MCF-7: 93.08 ± 3.74
- Measure
- other
- Value
- 93.08 ± 3.74 µM
- Target
- MCF-7
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 ON against MDA-MB-231: 60.66* ± 1.84
- Measure
- other
- Value
- 60.66* ± 1.84
- Target
- MDA-MB-231
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 OFF against MDA-MB-231: 71.48* ± 6.61
- Measure
- other
- Value
- 71.48* ± 6.61
- Target
- MDA-MB-231
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 ON against MDA-MB-468: 11.57* ± 1.37
- Measure
- other
- Value
- 11.57* ± 1.37
- Target
- MDA-MB-468
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail RuRW6 OFF against MDA-MB-468: 31.61* ± 0.24
- Measure
- other
- Value
- 31.61* ± 0.24
- Target
- MDA-MB-468
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-004032, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00