PEPDIA-PLP-003672

Table 1: Indolicidin MSSA 18.8 μM. Section 2.1: 'The MICs for MSSA were ... 18.8 µM ... for indolicidin'

Table 1: Indolicidin MRSA 43.8 μM. Section 2.1: 'The MICs for MRSA were ... 2.5-fold higher for indolicidin'

Section 2.2: 'Only one combination yielded a synergistic effect, which was at 12.5 μM P10 and 3.125 μM indolicidin' against MRSA. Section 2.4: 'the combination of 3.125 μM indolicidin and 12.5 μM P10 yielded a synergistic effect against MRSA'

Section 2.3: 'Quantification of these findings showed a 55% ... drop in viability for indolicidin hydrogels formed with 1× ... soluble MICs'

Section 2.3: 'Quantification of these findings showed a ... 88% drop in viability for indolicidin hydrogels formed with ... 2× soluble MICs'

Section 2.4: 'At P10 and indolicidin AMP concentrations above 0.5× synergistic concentrations, hydrogels completely killed the bacteria' and 'This observed effect at 0.5× MIC is reflective of a concentration of only 1.56 μM and 6.25 μM for indolicidin and P10, respectively.'

Discussion: 'The other peptide-producing strains from the panel exhibited no prominent antimicrobial effect against the target bacterium.'

Section 2.6: 'For every 100 cells counted across each AMP group there was, at most, one cell which displayed a nuclear red stain, resulting in viability at or above 99%' and 'MSCs were seeded onto RGD-functionalized ... AMP hydrogels at the highest concentration, 2× MIC for each AMP'

Section 2.6: 'For every 100 cells counted across each AMP group there was, at most, one cell which displayed a nuclear red stain, resulting in viability at or above 99%' and 'MSCs were seeded onto RGD-functionalized ... AMP hydrogels at ... the synergistic concentrations for P10 and indolicidin' at double their synergistic concentrations