ProForma 2.0
Not calculated for this record
Back to Primary literature
Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003496
pep2
Aliases: pep2
Normalized sequence
FIGAIARLLSKIF
13 amino acids
Release PepDiana-V1-20260620
5
Activity records
1
Source papers
5
Positive
0
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 3 records
PMC12713444
3 observationsAntimicrobialAntibacterialPositive observation
Record detail Results text: 'complete bacterial inhibition was observed at ... 6.25 μg/mL for BmKn2' (free peptide). Figure 3b caption confirms planktonic growth inhibition.
- Measure
- MIC
- Value
- 6.25 μg/mL
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Results text: 'complete bacterial inhibition was observed at ... 6.25 μg/mL for BmKn2' (peptide-loaded MSNs). Figure 3b caption confirms planktonic growth inhibition.
- Measure
- MIC
- Value
- 6.25 μg/mL
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Results text: 'The MBEC for both peptides was determined to be 50 μg/mL, at which no viable colonies were detected after 24 h.' Figure 3d caption confirms biofilm eradication.
- Measure
- other
- Value
- 50 μg/mL (MBEC)
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
Toxicity 2 records
PMC12713444
2 observationsToxicityCytotoxicPositive observation
Record detail Results text: 'BmKn2-MSNs exhibited reduced cytotoxicity compared to the free peptide, particularly at higher concentrations (IC50 = 201 μg/mL).' Figure 5b.
- Measure
- other
- Value
- 201 μg/mL
- Target
- MRC-5
- Assay
- Not reported by source
ToxicityCytotoxicPositive observation
Record detail Results text: 'BmKn2-MSNs exhibited reduced cytotoxicity compared to the free peptide, particularly at higher concentrations.' Figure 5b shows free BmKn2 cytotoxicity curve.
- Measure
- cell_viability
- Value
- reduced cytotoxicity compared to free peptide
- Target
- MRC-5
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003496, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00