ProForma 2.0
validated simple linear
YGLYPR
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003248
YR6
Aliases: YR6
Normalized sequence
YGLYPR
6 amino acids
Release PepDiana-V1-20260620
6
Activity records
1
Source papers
2
Positive
4
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
767.8715 Da
Molecular formula
C37H53N9O9
Theoretical pI
8.5897
Net charge at pH 7
0.7581
GRAVY
-0.8833
Instability index
2.1833
Aromaticity
0.3333
Topological polar surface area
302.39 Ų
cLogP
-0.8341
Hydrogen-bond donors
11
Hydrogen-bond acceptors
10
Rotatable bonds
20
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{Y.G.L.Y.P.R}$$$$V2.0
Canonical SMILES
validated
CC(C)CC(NC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)O
Isomeric SMILES
validated
CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Immunomodulatory 4 records
PMC10221837
4 observationsImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: YR6 at 12.5 μg/mL, NO Inhibition Rate = 14.51 ± 0.15%.
- Measure
- percent_inhibition
- Value
- 14.51 ± 0.15%
- Target
- RAW264.7
- Assay
- Not reported by source
ImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: YR6 at 25 μg/mL, NO Inhibition Rate = 17.81 ± 0.34%.
- Measure
- percent_inhibition
- Value
- 17.81 ± 0.34%
- Target
- RAW264.7
- Assay
- Not reported by source
ImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: YR6 at 50 μg/mL, NO Inhibition Rate = 10.46 ± 0.09%.
- Measure
- percent_inhibition
- Value
- 10.46 ± 0.09%
- Target
- RAW264.7
- Assay
- Not reported by source
ImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: YR6 at 100 μg/mL, NO Inhibition Rate = 5.65 ± 0.37%.
- Measure
- percent_inhibition
- Value
- 5.65 ± 0.37%
- Target
- RAW264.7
- Assay
- Not reported by source
Antioxidant 2 records
PMC10221837
2 observationsAntioxidantPositive observation
Record detail Compared with the original hexapeptide YR6, the IC50 values of the hexapeptides AGR6 and YGR6 decreased from 2.442 ± 0.0066 mmol/L to 2.339 ± 0.0047 mmol/L (p < 0.01) and 1.695 ± 0.0108 mmol/L (p < 0.01), respectively.
- Measure
- other
- Value
- 2.442 ± 0.0066 mmol/L
- Target
- Not reported by source
- Assay
- Not reported by source
AntioxidantPositive observation
Record detail Furthermore, compared with the original hexapeptide YR6, the IC50 values of the hexapeptides AGR6 and YGR6 decreased from 0.844 ± 0.0020 mmol/L to 0.6065 ± 0.0147 mmol/L (p < 0.01) and 0.5929 ± 0.0050 mmol/L (p < 0.01), respectively.
- Measure
- other
- Value
- 0.844 ± 0.0020 mmol/L
- Target
- Not reported by source
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003248, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00