ProForma 2.0
validated simple linear
TNGLSQTSQLAGR
Back to Primary literature
Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-002822
Pis v 2.0101
Aliases: Pis v 2.0101
Normalized sequence
TNGLSQTSQLAGR
13 amino acids
Release PepDiana-V1-20260620
34
Activity records
1
Source papers
34
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1332.4201 Da
Molecular formula
C53H93N19O21
Theoretical pI
9.4101
Net charge at pH 7
0.3982
GRAVY
-0.7231
Instability index
15.7385
Aromaticity
0
Topological polar surface area
684.61 Ų
cLogP
-11.9933
Hydrogen-bond donors
24
Hydrogen-bond acceptors
22
Rotatable bonds
45
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{T.N.G.L.S.Q.T.S.Q.L.A.G.R}$$$$V2.0
Canonical SMILES
validated
CC(C)CC(NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(N)C(C)O)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)O)C(C)O
Isomeric SMILES
validated
CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 20 records
PMC7149036
20 observationsAntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MIC against S. aureus (PTCC 1431) = 12 µg/mL.
- Measure
- MIC
- Value
- 12 µg/mL
- Target
- Staphylococcus aureus
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MBC against S. aureus (PTCC 1431) = 25 µg/mL.
- Measure
- MBC
- Value
- 25 µg/mL
- Target
- Staphylococcus aureus
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MIC against S. epidermis (PTCC 1435) = 12 µg/mL.
- Measure
- MIC
- Value
- 12 µg/mL
- Target
- Staphylococcus epidermidis
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MBC against S. epidermis (PTCC 1435) = 12 µg/mL.
- Measure
- MBC
- Value
- 12 µg/mL
- Target
- Staphylococcus epidermidis
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MIC against B. cereus (PTCC 1247) = 6.25 µg/mL.
- Measure
- MIC
- Value
- 6.25 µg/mL
- Target
- Bacillus cereus
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MBC against B. cereus (PTCC 1247) = 13.5 µg/mL.
- Measure
- MBC
- Value
- 13.5 µg/mL
- Target
- Bacillus cereus
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MIC against M. luteus (ATCC 9341) = 10 µg/mL.
- Measure
- MIC
- Value
- 10 µg/mL
- Target
- Micrococcus luteus
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram+Positive observation
Record detail Table 3: Pis v 2.0101 MBC against M. luteus (ATCC 9341) = 22 µg/mL.
- Measure
- MBC
- Value
- 22 µg/mL
- Target
- Micrococcus luteus
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MIC against E. coli (ATCC 1533) = 50 µg/mL.
- Measure
- MIC
- Value
- 50 µg/mL
- Target
- Escherichia coli
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MBC against E. coli (ATCC 1533) = 112 µg/mL.
- Measure
- MBC
- Value
- 112 µg/mL
- Target
- Escherichia coli
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MIC against P. aeruginosa (PTCC 1074) = 80 µg/mL.
- Measure
- MIC
- Value
- 80 µg/mL
- Target
- Pseudomonas aeruginosa
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MBC against P. aeruginosa (PTCC 1074) = 145 µg/mL.
- Measure
- MBC
- Value
- 145 µg/mL
- Target
- Pseudomonas aeruginosa
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MIC against S. typhi (PTCC 1609) = 60 µg/mL.
- Measure
- MIC
- Value
- 60 µg/mL
- Target
- Salmonella typhi
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MBC against S. typhi (PTCC 1609) = 90 µg/mL.
- Measure
- MBC
- Value
- 90 µg/mL
- Target
- Salmonella typhi
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MIC against S. marcescens (PTCC 1267) = 60 µg/mL.
- Measure
- MIC
- Value
- 60 µg/mL
- Target
- Serratia marcescens
- Assay
- Micro-dilution method
AntimicrobialAnti-Gram-Positive observation
Record detail Table 3: Pis v 2.0101 MBC against S. marcescens (PTCC 1267) = 73.2 µg/mL.
- Measure
- MBC
- Value
- 73.2 µg/mL
- Target
- Serratia marcescens
- Assay
- Micro-dilution method
AntimicrobialAntifungalPositive observation
Record detail Table 3: Pis v 2.0101 MIC against C. albicans (ATCC 10231) = 10 µg/mL.
- Measure
- MIC
- Value
- 10 µg/mL
- Target
- Candida albicans
- Assay
- Micro-dilution method
AntimicrobialAntifungalPositive observation
Record detail Table 3: Pis v 2.0101 MFC against C. albicans (ATCC 10231) = 10 µg/mL.
- Measure
- other
- Value
- 10 (MFC)
- Target
- Candida albicans
- Assay
- Micro-dilution method
AntimicrobialAntifungalPositive observation
Record detail Table 3: Pis v 2.0101 MIC against A. niger (ATCC 16404) = 50 µg/mL.
- Measure
- MIC
- Value
- 50 µg/mL
- Target
- Aspergillus niger
- Assay
- Micro-dilution method
AntimicrobialAntifungalPositive observation
Record detail Table 3: Pis v 2.0101 MFC against A. niger (ATCC 16404) = 50 µg/mL.
- Measure
- other
- Value
- 50 (MFC)
- Target
- Aspergillus niger
- Assay
- Micro-dilution method
Anticancer 6 records
PMC7149036
6 observationsAnticancerCytotoxicPositive observation
Record detail Table 5: Pis v 2.0101 IC50 against MCF-7 = 28.11 ± 0.88 µg/mL.
- Measure
- other
- Value
- 28.11 ± 0.88 µg/mL
- Target
- MCF-7
- Assay
- MTT assay
AnticancerCytotoxicPositive observation
Record detail Table 5: Pis v 2.0101 IC50 against A2780 = 33.95 ± 0.42 µg/mL.
- Measure
- other
- Value
- 33.95 ± 0.42 µg/mL
- Target
- A2780
- Assay
- MTT assay
AnticancerCytotoxicPositive observation
Record detail Table 5: Pis v 2.0101 IC50 against PC3 = 34.05 ± 0.42 µg/mL.
- Measure
- other
- Value
- 34.05 ± 0.42 µg/mL
- Target
- PC3
- Assay
- MTT assay
AnticancerCytotoxicPositive observation
Record detail Table 5: Pis v 2.0101 IC50 against DU-145 = 38.63 ± 0.80 µg/mL.
- Measure
- other
- Value
- 38.63 ± 0.80 µg/mL
- Target
- DU-145
- Assay
- MTT assay
AnticancerCytotoxicPositive observation
Record detail Table 5: Pis v 2.0101 IC50 against U-87-MG = 26.34 ± 0.88 µg/mL.
- Measure
- other
- Value
- 26.34 ± 0.88 µg/mL
- Target
- U-87-MG
- Assay
- MTT assay
AnticancerCytotoxicPositive observation
Record detail Table 5: Pis v 2.0101 IC50 against HTC = 28.11 ± 0.88 µg/mL.
- Measure
- other
- Value
- 28.11 ± 0.88 µg/mL
- Target
- HTC
- Assay
- MTT assay
Antiviral 4 records
PMC7149036
4 observationsAntiviralGeneral AntiviralPositive observation
Record detail Table 4: Pis v 2.0101 IC50 against CV-B2 = 37.50 ± 1.01 µg/mL, SI = 17.30.
- Measure
- other
- Value
- 37.50 ± 1.01 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
AntiviralGeneral AntiviralPositive observation
Record detail Table 4: Pis v 2.0101 IC50 against CV-B3 = 35.61 ± 1.03 µg/mL, SI = 18.25.
- Measure
- other
- Value
- 35.61 ± 1.03 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
AntiviralGeneral AntiviralPositive observation
Record detail Table 4: Pis v 2.0101 IC50 against CV-B4 = 30.20 ± 1.01 µg/mL, SI = 23.52.
- Measure
- other
- Value
- 30.20 ± 1.01 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
AntiviralGeneral AntiviralPositive observation
Record detail Table 4: Pis v 2.0101 IC50 against CV-B5 = 31.77 ± 1.02 µg/mL, SI = 20.41.
- Measure
- other
- Value
- 31.77 ± 1.02 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
Toxicity 4 records
PMC7149036
4 observationsToxicityCytotoxicPositive observation
Record detail Table 4: Pis v 2.0101 CC50 against CV-B2 = 648.75 ± 1.02 µg/mL.
- Measure
- CC50
- Value
- 648.75 ± 1.02 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
ToxicityCytotoxicPositive observation
Record detail Table 4: Pis v 2.0101 CC50 against CV-B3 = 649.88 ± 1.01 µg/mL.
- Measure
- CC50
- Value
- 649.88 ± 1.01 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
ToxicityCytotoxicPositive observation
Record detail Table 4: Pis v 2.0101 CC50 against CV-B4 = 710.30 ± 1.03 µg/mL.
- Measure
- CC50
- Value
- 710.30 ± 1.03 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
ToxicityCytotoxicPositive observation
Record detail Table 4: Pis v 2.0101 CC50 against CV-B5 = 648.42 ± 1.03 µg/mL.
- Measure
- CC50
- Value
- 648.42 ± 1.03 µg/mL
- Target
- HEp-2
- Assay
- MTT assay
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-002822, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00