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PEPDIA-INT-065575

Silver

Amp1L (1-2)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1LK

Length

Molecular weight

259.35 Da

Formula

C12H25N3O3

Structure type

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

259.3452 Da

Molecular formula

C12H25N3O3

Theoretical pI

8.7501

Net charge at pH 7

0.7591

GRAVY

-0.05

Instability index

-37.45

Aromaticity

Topological polar surface area

118.44 Å²

cLogP

0.0582

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HELM 2.0

validated simple linear

PEPTIDE1{L.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(N)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-065575,
  title = {Amp1L (1-2)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-065575},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Amp1L (1-2). (2026). PepDiana record PEPDIA-INT-065575. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-065575

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (22 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P065575_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ22857camp / linked
CTPDB_P065575_ACT_camp_0001	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ22857camp / linked
CTPDB_P065575_ACT_camp_0002	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ22857camp / linked
CTPDB_P065575_ACT_dbaasp_0016	Antimicrobial	-	1.56 µM	Pseudomonas aeruginosa PAO1	Not reported by source	DBAASPS_21231_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0017	Antimicrobial	-	1.56 µM	Escherichia coli K-12	Not reported by source	DBAASPS_21231_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0018	Antimicrobial	-	1.56 µM	Staphylococcus aureus ATCC 6538P	Not reported by source	DBAASPS_21231_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0019	Antimicrobial	-	1.56 µM	Bacillus subtilis ATCC 6051	Not reported by source	DBAASPS_21231_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0020	Antimicrobial	-	45 µM	Murine macrophage cells RAW 264.7	Not reported by source	DBAASPS_21231_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0003	Antimicrobial	-	1.56 µM	Staphylococcus aureus USA 300	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0004	Antimicrobial	-	>50 µM	Pseudomonas aeruginosa PAO1	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0005	Antimicrobial	-	3.1 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0006	Antimicrobial	-	6.2-12.5 µM	Klebsiella pneumoniae	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0007	Antimicrobial	-	1.56 µM	Staphylococcus aureus USA 200	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0008	Antimicrobial	-	1.56 µM	Staphylococcus aureus USA 400	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0009	Antimicrobial	-	3.1 µM	Staphylococcus aureus UAMS-1	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0010	Antimicrobial	-	1.56 µM	Staphylococcus aureus MU50	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0011	Antimicrobial	-	1.56 µM	Staphylococcus aureus Newman	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0012	Antimicrobial	-	1.56 µM	Staphylococcus epidermidis	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0013	Antimicrobial	-	6.25 µM	Candida albicans ATCC 10231	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0014	Antimicrobial	-	1.5 µM	Candida glabrata ATCC 2001	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_dbaasp_0015	Antimicrobial	-	1.56 µM	Candida tropicalis ATCC 13803	Not reported by source	DBAASPS_9825_chain0dbaasp / linked
CTPDB_P065575_ACT_plantpepdb_0021	Unknown	Taste	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2613plantpepdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003818 View all experimental records

Provenance

Source database records (5)

camp

CAMPSQ22857

Raw sequence

dbaasp

DBAASPS_9825_chain0

Raw sequence

dbaasp

DBAASPS_21229_chain0

Raw sequence

dbaasp

DBAASPS_21231_chain0

Raw sequence

plantpepdb

PPepDB_2613

Raw sequence

Citation trail

Literature (2 records)

-

--PMID 26257894

Site-Specific Isopeptide Bond Formation: A Powerful Tool for the Generation of Potent and Nontoxic Antimicrobial Peptides.

Wani NA, Stolovicki E, Hur DB, Shai Y

J Med Chem2022PMID 35290038

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:16.597675+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "<<12.5",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "15",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "55",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293 cells"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  }
]