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PEPDIA-INT-060565

Gold

Temporin-B, Temporin-1Tb

85

Quality

7

Source DBs

95

Activities

13

Source refs

13

Literature

1

Patents

Integrated record

Sequence and molecular profile

LLPIVGNLLKSLL
Indexed sequence13 aa
1LLPIVGNLLKSLL

Length

13

Molecular weight

1392.79 Da

Formula

C67H121N15O16

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

-

Gene

-

Residue composition

L
6
P
1
I
1
V
1
G
1
N
1
K
1
S
1

Physicochemical profile

Hydrophobic8

Membrane affinity proxy

Polar2

Solubility proxy

Charged1

Net charge proxy +1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1392.7682 Da

Molecular formula

C67H121N15O16

Theoretical pI

8.7501

Net charge at pH 7

0.7591

GRAVY

1.6385

Instability index

-2.0769

Aromaticity

0

Topological polar surface area

493.07 Ų

cLogP

-0.6711

Hydrogen-bond donors

16

Hydrogen-bond acceptors

17

Rotatable bonds

46

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

LLPIVGNLLKSLL

HELM 2.0

validated simple linear

PEPTIDE1{L.L.P.I.V.G.N.L.L.K.S.L.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(N)CC(C)C)C(=O)NC(C(=O)NCC(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-060565,
  title = {Temporin-B, Temporin-1Tb},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-060565},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Temporin-B, Temporin-1Tb. (2026). PepDiana record PEPDIA-INT-060565. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-060565

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (95 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P060565_ACT_apd_0000AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceAP00095apd / linked
CTPDB_P060565_ACT_apd_0001Antiviral-Not available in the current structured importUnknownNot reported by sourceAP00095apd / linked
CTPDB_P060565_ACT_apd_0002AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourceAP00095apd / linked
CTPDB_P060565_ACT_apd_0004Antiparasitic-Not available in the current structured importUnknownNot reported by sourceAP00095apd / linked
CTPDB_P060565_ACT_apd_0005BioregulatoryChemotacticNot available in the current structured importUnknownNot reported by sourceAP00095apd / linked
CTPDB_P060565_ACT_apd_0006AntimicrobialAnti-BiofilmNot available in the current structured importUnknownNot reported by sourceAP00095apd / linked
CTPDB_P060565_ACT_camp_0007AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ267camp / linked
CTPDB_P060565_ACT_camp_0008AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ267camp / linked
CTPDB_P060565_ACT_camp_0009AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ267camp / linked
CTPDB_P060565_ACT_dbaasp_0076Antimicrobial-25 µg/mlStaphylococcus aureus A170Not reported by sourceDBAASPS_5732_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0077Antimicrobial-30 µg/mlStaphylococcus epidermidisNot reported by sourceDBAASPS_5732_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0078Antimicrobial->100 µg/mlSalmonella typhimuriumNot reported by sourceDBAASPS_5732_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0079Antimicrobial->100 µg/mlEscherichia coliNot reported by sourceDBAASPS_5732_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0010Antimicrobial-2.8 µMBacillus megaterium Bm11Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0011Antimicrobial-6.0 µMStaphylococcus aureus Cowan 1Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0012Antimicrobial-7.0 µMYersinia pseudotuberculosisNot reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0013Antimicrobial-7.0 µMStreptococcus pyogenes Beta-hemolytic group ANot reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0014Antimicrobial-11.2 µMEscherichia coli D21Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0015Antimicrobial-13.2 µMEscherichia coli D21e7Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0016Antimicrobial-10.0 µMEscherichia coli D21f1Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0017Antimicrobial-3.3 µMEscherichia coli D21f2Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0018Antimicrobial-11.2 µMEscherichia coli D22Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0019Antimicrobial->360 µMPseudomonas aeruginosa ATCC 15692Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0020Antimicrobial-4.0 µMCandida albicans ATCC 10261Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0021Antimicrobial->64 µMPseudomonas aeruginosaNot reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0022Antimicrobial-8.6 µMLeishmania donovani MHOM/S.D./00/1S-2D (promastigote)Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0023Antimicrobial-8.6 µMLeishmania donovani MHOM/S.D./00/1S-2D (amastigote)Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0024Antimicrobial-100 µMEscherichia coliNot reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0025Antimicrobial-100 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0026Antimicrobial-100 µMKlebsiella pneumoniae ATCC 13883Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0027Antimicrobial-200 µMSalmonella enterica subsp. enterica serovar Typhimurium ATCC 14028Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0028Antimicrobial-25 µMBacillus subtilisNot reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0029Antimicrobial-25 µMStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0030Antimicrobial-25 µMStreptococcus pyogenes ATCC 19615Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0031Antimicrobial-50 µMEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0032Antimicrobial-12 µMStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0033Antimicrobial-6 µMStaphylococcus epidermidis ATCC 35984Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0034Antimicrobial-48 µMKlebsiella pneumoniae ATCC BAA-1706Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0035Antimicrobial-48 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0036Antimicrobial-NAHuman lung carcinoma A549Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0037Antimicrobial-128 µg/mlKlebsiella pneumoniae NCTC 13368Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0038Antimicrobial->128 µg/mlKlebsiella pneumoniae NCTC 13368Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0039Antimicrobial-128 µg/mlKlebsiella pneumoniae M6Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0040Antimicrobial->128 µg/mlKlebsiella pneumoniae M6Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0041Antimicrobial-32 µg/mlAcinetobacter baumannii AYENot reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0042Antimicrobial-64 µg/mlAcinetobacter baumannii AYENot reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0043Antimicrobial-64 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0044Antimicrobial-128 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0045Antimicrobial->128 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0046Antimicrobial->128 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0047Antimicrobial-128 µg/mlPseudomonas aeruginosa NCTC 13437Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0048Antimicrobial->128 µg/mlPseudomonas aeruginosa NCTC 13437Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0049Antimicrobial-64 µg/mlEscherichia coli NCTC 12923Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0050Antimicrobial-128 µg/mlEscherichia coli NCTC 12923Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0051Antimicrobial-16 µg/mlStaphylococcus aureus NCTC 6571Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0052Antimicrobial-16 µg/mlStaphylococcus aureus NCTC 6571Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0053Antimicrobial-16 µg/mlStaphylococcus aureus NCTC 13616Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0054Antimicrobial-64 µg/mlStaphylococcus aureus NCTC 13616Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0055Antimicrobial-32 µg/mlStaphylococcus aureus NCTC 13277Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0056Antimicrobial-32 µg/mlStaphylococcus aureus NCTC 13277Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0057Antimicrobial-64 µg/mlEnterococcus faecalis NCTC 775Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0058Antimicrobial-128 µg/mlEnterococcus faecalis NCTC 775Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0059Antimicrobial-64 µg/mlEnterococcus faecalis NCTC 12201Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0060Antimicrobial->128 µg/mlEnterococcus faecalis NCTC 12201Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0061Antimicrobial-32 µg/mlCandida albicans NCPF 3179Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0062Antimicrobial-128 µg/mlCandida albicans NCPF 3179Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0063Antimicrobial-2.507 µg/mlHSV-1Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0064Antimicrobial-93 µg/mlHuman cervical carcinoma HeLa S3Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0065Antimicrobial-8 µMCorynebacterium jeikeium ATCC BAA-949Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0066Antimicrobial-50 µMEscherichia coli D21Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0067Antimicrobial-50 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0068Antimicrobial-200 µMPseudomonas aeruginosa ATCC 15692Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0069Antimicrobial-200 µMAeromonas hydrophila Rt-6Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0070Antimicrobial-3 µMStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0071Antimicrobial-12 µMStaphylococcus aureus Cowan 1Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0072Antimicrobial-6 µMBacillus megaterium Bm11Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0073Antimicrobial-6 µMStaphylococcus epidermidis ATCC 12228Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0074AnticancerCytotoxic58 µMHuman lung carcinoma A549Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dbaasp_0075Antimicrobial-38 µMHuman Influenza A Virus H1N1 A/PR/8/34Not reported by sourceDBAASPS_847_chain0dbaasp / linked
CTPDB_P060565_ACT_dramp_0080Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP01739dramp / linked
CTPDB_P060565_ACT_dramp_0081AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceDRAMP01739dramp / linked
CTPDB_P060565_ACT_dramp_0082AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceDRAMP01739dramp / linked
CTPDB_P060565_ACT_dramp_0083AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceDRAMP01739dramp / linked
CTPDB_P060565_ACT_dramp_0084Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP27798dramp / linked
CTPDB_P060565_ACT_dramp_0085AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceDRAMP27798dramp / linked
CTPDB_P060565_ACT_hemolytik_0087ToxicityHemolytic120.0 µMErythrocytesNot reported by source3374hemolytik / linked
CTPDB_P060565_ACT_hemolytik_0086ToxicityHemolytic120.0 µMErythrocytesNot reported by source4111hemolytik / linked
CTPDB_P060565_ACT_parapep_0088AntiparasiticAntiparasitic8.6 µMUnknownMTT assay1243parapep / linked
CTPDB_P060565_ACT_parapep_0089AntiparasiticAntiparasitic50.0 µMUnknownMTT assay1350parapep / linked
CTPDB_P060565_ACT_parapep_0090AntiparasiticAntiparasiticNot available in the current structured importUnknownAlamar Blue assay1606parapep / linked
CTPDB_P060565_ACT_satpdb_0091AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourcesatpdb21019satpdb / linked
CTPDB_P060565_ACT_satpdb_0092Antiparasitic-Not available in the current structured importUnknownNot reported by sourcesatpdb21019satpdb / linked
CTPDB_P060565_ACT_satpdb_0093ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb21019satpdb / linked
CTPDB_P060565_ACT_satpdb_0094Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb21019satpdb / linked
CTPDB_P060565_ACT_satpdb_0095Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb28183satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

4

Records

1

Papers

3

Positive

1

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003841View all experimental records

Provenance

Source database records (13)

apd

AP00095

Raw sequence

LLPIVGNLLKSLL

camp

CAMPSQ267

Raw sequence

LLPIVGNLLKSLL

dbaasp

DBAASPS_847_chain0

Raw sequence

LLPIVGNLLKSLL

dbaasp

DBAASPS_5732_chain0

Raw sequence

LLPIVGNLLKSLL

dramp

DRAMP01739

Raw sequence

LLPIVGNLLKSLL

dramp

DRAMP27798

Raw sequence

LLPIVGNLLKSLL

hemolytik

4111

Raw sequence

LLPIVGNLLKSLL

hemolytik

3374

Raw sequence

LLPIVGNLLKSLL

parapep

1243

Raw sequence

LLPIVGNLLKSLL

parapep

1350

Raw sequence

LLPIVGNLLKSLL

parapep

1606

Raw sequence

LLPIVGNLLKSLL

satpdb

satpdb21019

Raw sequence

LLPIVGNLLKSLL

satpdb

satpdb28183

Raw sequence

LLPIVGNLLKSLL

Citation trail

Literature (13 records)

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996

Eur J Biochem1996PMID 9022710

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 20606068

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 15513914

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 24419338

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 28443279

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 30718667

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 29483113

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 32722535

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 16867990

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D

Eur J Biochem1996PMID 33538061

Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria.

Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A

Biochim Biophys Acta2013PMID 23403136

IP evidence

Patents (1)

US 10723764

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.941613+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µM",
      "value": "32",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human PBMC"
    },
    {
      "source_db": "dbaasp",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "90.4",
      "source_db": "dbaasp",
      "assay_method": "50% Cytotoxicity",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Vero cells"
    },
    {
      "unit": "µg/ml",
      "value": "84",
      "source_db": "dbaasp",
      "assay_method": "50% Cytotoxicity",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293 cells"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.9022710] LC>120 µM against Human red blood cells. (LC: Lethal concentration)##[Ref.28443279] 1% hemolysis at 96μM against human red blood cells.",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "pdb_id": "6GIL resolved by NMR.",
  "source_db": "dramp"
}