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PEPDIA-INT-055123

Gold

RW

80

Quality

7

Source DBs

55

Activities

23

Source refs

15

Literature

0

Patents

Integrated record

Sequence and molecular profile

RW
Indexed sequence2 aa
1RW

Length

2

Molecular weight

360.42 Da

Formula

C17H24N6O3

Structure type

Linear

Synthesis

Synthetic

Chirality

L

Family

-

Gene

-

Residue composition

R
1
W
1

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

360.4109 Da

Molecular formula

C17H24N6O3

Theoretical pI

9.75

Net charge at pH 7

0.7601

GRAVY

-2.7

Instability index

291.4

Aromaticity

0.5

Topological polar surface area

170.11 Ų

cLogP

-0.1296

Hydrogen-bond donors

7

Hydrogen-bond acceptors

4

Rotatable bonds

9

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RW

HELM 2.0

validated simple linear

PEPTIDE1{R.W}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-055123,
  title = {RW},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-055123},
  note = {Accessed from local PepDiana development build}
}

APA-style note

RW. (2026). PepDiana record PEPDIA-INT-055123. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-055123

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (55 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P055123_ACT_ahtpdb_0003Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownUdenigwe et al.1221ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0004Metabolic/CardiovascularACE Inhibitor20.0 mMUnknownNot reported by source1497ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0005Metabolic/CardiovascularACE Inhibitor20.0 mMUnknownNot reported by source1513ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0006Metabolic/CardiovascularACE Inhibitor10.0 µMUnknownNot reported by source2058ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0007Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownNot reported by source2848ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0008Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3535ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0009Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3783ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0000Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4448ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0001Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4489ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0002Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4658ahtpdb / linked
CTPDB_P055123_ACT_ahtpdb_0010Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownNot reported by source6566ahtpdb / linked
CTPDB_P055123_ACT_avpdb_0011AntiviralGeneral AntiviralNilVacciniaPlaque assayAVPdb_AVP1529avpdb / unavailable
CTPDB_P055123_ACT_camp_0012AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ13077camp / linked
CTPDB_P055123_ACT_camp_0013AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ13077camp / linked
CTPDB_P055123_ACT_camp_0014AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ13077camp / linked
CTPDB_P055123_ACT_dbaasp_0032Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_12471_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0033Antimicrobial-15 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_12471_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0034Antimicrobial-15 µg/mlStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_12471_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0035Antimicrobial-10 µg/mlStaphylococcus epidermidis ATCC 27626Not reported by sourceDBAASPS_12471_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0036Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_12472_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0037Antimicrobial-50 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_12472_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0038Antimicrobial-50 µg/mlStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_12472_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0039Antimicrobial-25 µg/mlStaphylococcus epidermidis ATCC 27626Not reported by sourceDBAASPS_12472_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0040Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_12473_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0041Antimicrobial-25 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_12473_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0042Antimicrobial-25 µg/mlStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_12473_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0043Antimicrobial-25 µg/mlStaphylococcus epidermidis ATCC 27626Not reported by sourceDBAASPS_12473_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0044Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_12474_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0045Antimicrobial-50 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_12474_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0046Antimicrobial-50 µg/mlStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_12474_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0047Antimicrobial-20 µg/mlStaphylococcus epidermidis ATCC 27626Not reported by sourceDBAASPS_12474_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0015Antimicrobial-4300 µMEscherichia coli D31Not reported by sourceDBAASPS_258_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0016Antimicrobial-2100 µMStaphylococcus aureus ATCC BAA-44Not reported by sourceDBAASPS_258_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0017Antimicrobial-4700 µMEscherichia coli D31Not reported by sourceDBAASPS_258_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0018Antimicrobial-2300 µMStaphylococcus aureus ATCC BAA-44Not reported by sourceDBAASPS_258_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0019Antimicrobial-3.1 µMStaphylococcus aureus USA 300Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0020Antimicrobial->50 µMPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0021Antimicrobial->50 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0022Antimicrobial->50 µMKlebsiella pneumoniaeNot reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0023Antimicrobial-25 µMStaphylococcus aureus USA 200Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0024Antimicrobial-3.12 µMStaphylococcus aureus USA 400Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0025Antimicrobial->12.5 µMStaphylococcus aureus UAMS-1Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0026Antimicrobial->12.5 µMStaphylococcus aureus MU50Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0027Antimicrobial-6.2 µMStaphylococcus aureus NewmanNot reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0028Antimicrobial-6.25 µMStaphylococcus epidermidisNot reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0029Antimicrobial->25 µMCandida albicans ATCC 10231Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0030Antimicrobial->25 µMCandida glabrata ATCC 2001Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_dbaasp_0031Antimicrobial->25 µMCandida tropicalis ATCC 13803Not reported by sourceDBAASPS_9826_chain0dbaasp / linked
CTPDB_P055123_ACT_hemolytik_0048ToxicityHemolytic103.0 µMErythrocytesNot reported by source1077hemolytik / linked
CTPDB_P055123_ACT_plantpepdb_0049Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcePPepDB_183plantpepdb / linked
CTPDB_P055123_ACT_satpdb_0050ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb25509satpdb / linked
CTPDB_P055123_ACT_satpdb_0051Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb25509satpdb / linked
CTPDB_P055123_ACT_satpdb_0052Antiviral-Not available in the current structured importUnknownNot reported by sourcesatpdb26916satpdb / linked
CTPDB_P055123_ACT_satpdb_0053Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcesatpdb26916satpdb / linked
CTPDB_P055123_ACT_satpdb_0054Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb26916satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

3

Records

2

Papers

3

Positive

0

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-004027View all experimental records

Provenance

Source database records (23)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

ahtpdb

4448

Raw sequence

RW

ahtpdb

4489

Raw sequence

RW

ahtpdb

4658

Raw sequence

RW

ahtpdb

2058

Raw sequence

RW

ahtpdb

2848

Raw sequence

RW

ahtpdb

1221

Raw sequence

RW

ahtpdb

1497

Raw sequence

RW

ahtpdb

1513

Raw sequence

RW

ahtpdb

6566

Raw sequence

RW

ahtpdb

3535

Raw sequence

RW

ahtpdb

3783

Raw sequence

RW

avpdb

AVPdb_AVP1529

Raw sequence

RW

camp

CAMPSQ13077

Raw sequence

RW

dbaasp

DBAASPS_258_chain0

Raw sequence

RW

dbaasp

DBAASPS_9826_chain0

Raw sequence

RW

dbaasp

DBAASPS_12471_chain0

Raw sequence

RW

dbaasp

DBAASPS_12472_chain0

Raw sequence

Rw

dbaasp

DBAASPS_12473_chain0

Raw sequence

rW

dbaasp

DBAASPS_12474_chain0

Raw sequence

rw

hemolytik

1077

Raw sequence

RW

plantpepdb

PPepDB_183

Raw sequence

RW

satpdb

satpdb25509

Raw sequence

RW

satpdb

satpdb26916

Raw sequence

RW

Citation trail

Literature (15 records)

Modelling relationship between angiotensin-(I)-converting enzyme inhibition and the bitter taste of peptides

Are Hugo Pripp, Ylva Ardö

Food Chemistry - FOOD CHEM 01/2007; 102(3):880-888.2007

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

What are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach.

Zhou P et al.

Food Chem. 2013 Dec 1;141(3):2967-73.2013PMID 23871047

QSAR-aided in silico approach in evaluation of food proteins as precursors of ACE inhibitory peptides

Yuchen Gu, Kaustav Majumdar, Jianping Wu

Food Research International 44(8) October 2011, 2465–2474.2011

Inhibition strength of short peptides derived from an ACE inhibitory peptide.

Terashima M1, Oe M, Ogura K, Matsumura S.

J Agric Food Chem. 2011 Oct 26;59(20):11234-7.2011PMID 21923188

Antihypertensive Properties of Plant Protein Derived Peptides

Anne Pihlanto and Sari Ma?kinen

Bioactive Food Peptides in Health and Disease Edited by Blanca Hernandez-Ledesma and Chia-Chien Hsieh, ISBN 978-953-51-0964-8, 276 pages2013

Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides.

Wu J1, Aluko RE, Nakai S.

J Agric Food Chem. 2006 Feb 8;54(3):732-8.2006PMID 16448176

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

Cheung HS et al.,

J Biol Chem. 1980 Jan 25;255(2):401-7.1980PMID 6243277

MOTIFS WITH POTENTIAL PHYSIOLOGICAL ACTIVITY IN FOOD PROTEINS - BIOPEP DATABASE

Iwaniak, Anna; Dziuba, Bartlomiej

Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p592009

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Antiviral activity of selected antimicrobial peptides against vaccinia virus.

Mohan KV, Rao SS, Atreya CD.

Antiviral Res2010PMID 20347875

Length effects in antimicrobial peptides of the (RW)n series

Liu Z, Brady A, Young A, Rasimick B, Chen K, Zhou C, Kallenbach NR

Antimicrob Agents Chemother2007PMID 17145799

Small lipopeptides possess anti-biofilm capability comparable to daptomycin and vancomycin.

Mishra B, Lushnikova T, Wang G

RSC Adv2015PMID 26257894

The pharmacophore of short cationic antibacterial peptides.

Strøm MB, Haug BE, Skar ML, Stensen W, Stiberg T, Svendsen JS

J Med Chem2003PMID 12699374

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µM",
      "value": "8900",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Sheep erythrocytes"
    },
    {
      "unit": "µM",
      "value": "<<12.5",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "avpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CC"
}