PepDiana
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Primary experimental recordPositive observation

PMC13117951::ACT043835

DVGRG

Evidence text

Paper-level observation

pretreatment with 200 μM tuna peptides S1, S5, S6, and S7 significantly increased Nrf2 mRNA expression and decreased Keap1 mRNA expression in MLE-12 cells compared to the model group. (Figure 8)
textConfidence: medium

Assay observation

Activity
Antioxidant
Subtype
Not reported by source
Measure
other
Comparator
=
Raw observation
significantly increased Nrf2 mRNA, decreased Keap1 mRNA
Normalized measurement
=200
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Mus musculus
Assay method
Not reported by source
Sequence
DVGRG
Standardization
ready simple

Source publication

Antioxidant Peptides from Skipjack tuna: Ameliorate Function on Cigarette Smoke Extract-Induced COPD in Cell Model by Targeting Oxidative Stress, Inflammation and Apoptosis

Marine Drugs · 2026

DOI 10.3390/md24040140 PMC13117951
Parent mention

Related peptide identities

PEPDIA-PLP-000492

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.