PepDiana
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Primary experimental recordPositive observation

PMC12972984::ACT039564

MAVP

Evidence text

Paper-level observation

GelMAMAVP MPs system significantly attenuated VEGFR2 activation... downstream genes of VEGFR2 in GelMAMAVP MPs group, including VEGFR2, Map3k5, and Map2k4, were significantly inhibited... MAVP can also inhibit the expression of neuroinflammatory gene, such as TNF-α (Fig. 2H).
textConfidence: medium

Assay observation

Activity
Other
Subtype
Antibacterial
Measure
percent_inhibition
Comparator
=
Raw observation
significantly attenuated VEGFR2 activation; significantly inhibited VEGFR2, Map3k5, Map2k4, TNF-α gene expression
Normalized measurement
Not reported by source
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
HUVEC
Assay method
Not reported by source
Sequence
MAGGGATWLPPR
Standardization
ready simple

Source publication

Targeting VEGFR2 inhibition within a spatially-confined conduit promotes nerve self-resolution and alleviates mechanical allodynia

Bioactive Materials · 2026

DOI 10.1016/j.bioactmat.2026.03.009 PMC12972984
Parent mention

Related peptide identities

PEPDIA-PLP-001965

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.