PepDiana
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Primary experimental recordPositive observation

PMC10126514::ACT000314

P21

Evidence text

Paper-level observation

Figure 5: P21 polypeptide has a good inhibitory effect on the PC12 cytotoxicity caused by the aggregation of Aβ1-42 at a low concentration ratio (1:0.25 and 1:0.5). After the concentration ratio of P21 reached 1:1, with the increase of P21 concentration (1:2, 1:4), cell viability continued to increase, reaching the maximum at 1:4, which was close to the normal level.
textConfidence: medium

Assay observation

Activity
Toxicity
Subtype
Cytotoxic
Measure
cell_viability
Comparator
=
Raw observation
cell viability increased with P21 concentration, reaching maximum at 1:4 ratio, close to normal level
Normalized measurement
=1
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Rattus norvegicus
Assay method
Not reported by source
Sequence
YVRHLKYVRHLK
Standardization
ready simple

Source publication

The interaction of peptide inhibitors and Aβ protein: Binding mode analysis, inhibition of the formation of Aβ aggregates, and then exert neuroprotective effects.

Frontiers in Aging Neuroscience · 2023

DOI 10.3389/fnagi.2023.1139418 PMC10126514
Parent mention

Related peptide identities

PEPDIA-PLP-003361

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.