Primary experimental recordNegative / threshold

PMC10126514::ACT000309

P21

Evidence text

Paper-level observation

Figure 3D: the cell viability of P21 was significantly reduced at 25 uM (p < 0.05), and the cytotoxic peptide concentration produced at this time was higher than that of other peptides, and the cytotoxicity of P21 itself was lower.

textConfidence: medium

Assay observation

Activity

Toxicity

Subtype

Cytotoxic

Measure

cell_viability

Comparator

Raw observation

cell viability significantly reduced at 25 uM (p<0.05)

Normalized measurement

<0.05

Value minimum

Not reported by source

Value maximum

Not reported by source

Target

Rattus norvegicus

Assay method

Not reported by source

Sequence

YVRHLKYVRHLK

Standardization

ready simple

Source publication

The interaction of peptide inhibitors and Aβ protein: Binding mode analysis, inhibition of the formation of Aβ aggregates, and then exert neuroprotective effects.

Frontiers in Aging Neuroscience · 2023

DOI 10.3389/fnagi.2023.1139418 PMC10126514

Parent mention

Related peptide identities

PEPDIA-PLP-003361

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.