AntimicrobialAntibacterialPositive observation
Record detail Table 1: Ctn[15-34] re MIC (μM) A. baumannii = 0.39
- Measure
- MIC
- Value
- 0.39 μM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
Source publication
From In Vitro Promise to In Vivo Reality: An Instructive Account of Infection Model Evaluation of Antimicrobial Peptides.
International Journal of Molecular Sciences · 2024
- Sequence status
- reported
- Standardization
- Sequence ready
- Source location
- table
- Activity records
- 5
Sequence evidence
Reported molecular identity
FPITVGIVMPKKFIKKLRKK
fpitvGivmpkkfikklrkk
Resolved peptide links
Experimental observations
Records linked to this mention
ToxicityCytotoxicPositive observation
Record detail Table 1: Ctn[15-34] re IC50 (μM) = 43. Methods Section 3.4 describes cytotoxicity assay on 1BR3G human fibroblast cells.
- Measure
- other
- Value
- 43 μM
- Target
- 1BR3G
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 1: Ctn[15-34] re t1/2 (min) = 921 (serum stability).
- Measure
- other
- Value
- 921 other
- Target
- Not reported by source
- Assay
- Not reported by source
ImmunomodulatoryPositive observation
Record detail Section 2.4: 'For Ctn[15-34] re ... at LPS/peptide ratios of 0.1:0.1, TNF-α levels evidencing high inflammation ... were found.'
- Measure
- other
- Value
- high inflammation at LPS/peptide 0.1:0.1
- Target
- human MNC
- Assay
- Not reported by source
ToxicityGeneral ToxicNegative / threshold
Record detail Section 2.2: 'Ctn[15-34] re ... an animal died within 3 min at 30 mg/kg, within 6 min at 15 mg/kg, and after 33 min at 5 mg/kg.' Sighting study.
- Measure
- MTD
- Value
- toxic: death within 3 min at 30 mg/kg, 6 min at 15 mg/kg, 33 min at 5 mg/kg
- Target
- Mus musculus
- Assay
- Not reported by source
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.