Nutrients · 2023
Sequence evidence
AHKFR
AHKFR
Experimental observations
Compared with the original pentapeptide LR5, the IC50 values of the replacement pentapeptides AR5 and LAR5 with reduced hydrophobicity increased from 2.6561 ± 0.0031 mmol/L to 6.985 ± 0.0002 mmol/L (p < 0.01) and 3.633 ± 0.0071 mmol/L (p < 0.01), respectively.
Compared with the original pentapeptide LR5, the IC50 values of the replacement pentapeptides AR5 and LAR5 increased from 0.6476 ± 0.0032 mmol/L to 0.6702 ± 0.0019 mmol/L (p < 0.05) and 0.6561 ± 0.0025 mmol/L (p < 0.05), respectively.
Table 1: AR5 at 12.5 μg/mL, NO Inhibition Rate = 12.36 ± 0.12%.
Table 1: AR5 at 25 μg/mL, NO Inhibition Rate = 6.76 ± 0.11%.
Table 1: AR5 at 50 μg/mL, NO Inhibition Rate = 9.31 ± 0.15%.
Table 1: AR5 at 100 μg/mL, NO Inhibition Rate = 8.80 ± 0.11%.
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.
