F-NZ2114

Table 1: FNZ MIC against S. aureus ATCC 43300 = 8 μg/mL (1.75 μM)

Table 1: FNZ MIC against S. aureus ATCC 43300 = 1.75 μM

Table 1: FNZ MIC against S. aureus ATCC 25923 = 8 μg/mL (1.75 μM)

Table 1: FNZ MIC against S. aureus ATCC 25923 = 1.75 μM

Table 1: FNZ MIC against S. aureus CVCC 546 = 8 μg/mL (1.75 μM)

Table 1: FNZ MIC against S. aureus CVCC 546 = 1.75 μM

Table 1: FNZ MIC against S. aureus E48 = 4 μg/mL (0.88 μM)

Table 1: FNZ MIC against S. aureus E48 = 0.88 μM

Table 1: FNZ MIC against S. hyicus ACCC 61734 = 8 μg/mL (1.75 μM)

Table 1: FNZ MIC against S. hyicus ACCC 61734 = 1.75 μM

Table 1: FNZ MIC against S. epidermidis ATCC 12228 = 8 μg/mL (1.75 μM)

Table 1: FNZ MIC against S. epidermidis ATCC 12228 = 1.75 μM

Table 1: FNZ MIC against S. agalactiae CAU-FRI 4 = 4 μg/mL (0.88 μM)

Table 1: FNZ MIC against S. agalactiae CAU-FRI 4 = 0.88 μM

Table 1: FNZ MIC against E. coli ATCC 25922 >128 μg/mL (>28.05 μM)

Table 1: FNZ MIC against E. coli ATCC 25922 >28.05 μM

Table 1: FNZ MIC against S. enterica ATCC 13076 >128 μg/mL (>28.05 μM)

Table 1: FNZ MIC against S. enterica ATCC 13076 >28.05 μM

Table 1: FNZ MIC against P. aeruginosa CICC 20625 >128 μg/mL (>28.05 μM)

Table 1: FNZ MIC against P. aeruginosa CICC 20625 >28.05 μM

Section 2.8.1: None of the concentrations of FNZ produced hemolytic activity on erythrocytes; no damage to mouse red blood cells (MRBCs) with FNZ in all scope-effective concentrations.

Section 2.8.1: FNZ showed low cytotoxicity (88.56% survival) toward mouse macrophages RAW264.7 cells at 128 μg/mL

Table 3: FNZ MIC against S. aureus ATCC 43300 after 20°C treatment = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 after 40°C treatment = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 after 60°C treatment = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 after 80°C treatment = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 after 100°C treatment = 16 μg/mL (3.5 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 at pH 2 = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 at pH 4 = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 at pH 6 = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 at pH 8 = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 at pH 10 = 16 μg/mL (3.5 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 50 mM Na+ = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 100 mM Na+ = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 150 mM Na+ = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 300 mM Na+ = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 500 mM Na+ = 16 μg/mL (3.5 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 50 mM Mg2+ = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 100 mM Mg2+ = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 150 mM Mg2+ = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 300 mM Mg2+ = 16 μg/mL (3.5 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in 500 mM Mg2+ >32 μg/mL (>7 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in Simulated Gastric Fluid (1 h) = 8 μg/mL (1.75 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in Artificial Intestinal Fluid (10 min) >16 μg/mL (>3.5 μM)

Table 3: FNZ MIC against S. aureus ATCC 43300 in Serum (25%) (1–4 h) = 8 μg/mL (1.75 μM)