Octopromycin

Octopromycin has shown minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 50 and 200 µg/mL, respectively, for a lab strain of A. baumannii [24].

Octopromycin has shown minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 50 and 200 µg/mL, respectively, for a lab strain of A. baumannii [24].

Octopromycin displayed inhibitory and eradication effects on A. baumannii biofilm, with an MBIC ranging from 350–500 μg/mL and an MBEC ranging from 600–700 μg/mL (data not shown).

Octopromycin displayed inhibitory and eradication effects on A. baumannii biofilm, with an MBIC ranging from 350–500 μg/mL and an MBEC ranging from 600–700 μg/mL (data not shown).

At the MBC of 200 μg/mL, the eradication level of mature biofilms exceeded 60%, which was consistent with our previous results [24].

A. baumannii persisters were killed in a dose-dependent manner by octopromycin; more than half of the persisters were significantly (p ≤ 0.05) eliminated by concentrations of octopromycin ≥2 × MIC (100 µg/mL).

Octopromycin resulted in a significant (p ≤ 0.05) reduction (23–74%) in alginate production at concentrations ranging from 25–300 μg/mL.

At the lowest concentration, the violacein inhibition level was 32.54% compared to the negative control.

The inhibitory activity was gradually enhanced with octopromycin treatment, reaching a maximum of 54.75% at a concentration of 300 μg/mL.

At 50 μg/mL, octopromycin decreased the swarming and swimming diameters up to 10.5 and 28.5 mm, respectively, compared to the control (51 and 43 mm, respectively).

At 200 μg/mL of octopromycin, swarming and swimming diameters decreased to 4.4 and 15.4 mm, respectively.

At 50 μg/mL, octopromycin decreased the swarming and swimming diameters up to 10.5 and 28.5 mm, respectively, compared to the control (51 and 43 mm, respectively).

At 200 μg/mL of octopromycin, swarming and swimming diameters decreased to 4.4 and 15.4 mm, respectively.

At 50 μg/mL, octopromycin decreased this diameter compared to the control (11.0 vs. 35.0 mm).

At 200 μg/mL, the twitching diameter was 0 mm (colony was absent).

octopromycin did not show considerable cytotoxic effects on human (HEK293T) or mouse (Raw264.7) cells at concentrations up to 400 μg/mL [24].

octopromycin did not show considerable cytotoxic effects on human (HEK293T) or mouse (Raw264.7) cells at concentrations up to 400 μg/mL [24].

also did not cause hemolysis in mouse red blood cells at high concentrations (<300 µg/mL) [24].