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Paper-scoped peptide mentionSequence not reported or unresolved

MPI-SP

PMC10043419::PEP000004

Source publication

Bioengineered bacterial outer membrane vesicles encapsulated Polybia–mastoparan I fusion peptide as a promising nanoplatform for bladder cancer immune-modulatory chemotherapy

Frontiers in Immunology · 2023

DOI 10.3389/fimmu.2023.1129771PMC10043419PMID 36999028
Sequence status
not reported or unresolved
Standardization
Sequence unresolved
Source location
unknown
Activity records
5

Sequence evidence

Reported molecular identity

The publication reports a peptide label or compound identity, but no sequence could be safely standardized from the available text, table, figure, or structure context.

In order to add the signal peptide (SP) of OmpA ... at the N terminal of MPI-N, PCR was adopted two times to fuse the DNA sequence of SP and MPI with pET43.1a-MPI-N as the template.

Experimental observations

Records linked to this mention

AnticancerCytotoxicPositive observation
Record detail

Both of them had a pronounced reduction of their viabilities when treated with bioengineered OMVs (OMV^MPI-N, OMV^MPI-SP, and OMV^MPI-C) for 24 h when compared with OMV^WT treatment.

Mention PMC10043419::PEP000004PMC10043419figure
Measure
cell_viability
Value
reduced viability
Target
MB49
Assay
Not reported by source
Source publication
AnticancerCytotoxicPositive observation
Record detail

Both of them had a pronounced reduction of their viabilities when treated with bioengineered OMVs (OMV^MPI-N, OMV^MPI-SP, and OMV^MPI-C) for 24 h when compared with OMV^WT treatment.

Mention PMC10043419::PEP000004PMC10043419figure
Measure
cell_viability
Value
reduced viability
Target
UMUC3
Assay
Not reported by source
Source publication
AnticancerCytotoxicNegative / threshold
Record detail

However, a non-carcinomatous cell named bEnd.3 ... exhibited no viability suppression when being treated with different OMVs at the concentration of <100 μg/ml (Figure S5).

Mention PMC10043419::PEP000004PMC10043419supplement
Measure
cell_viability
Value
no viability suppression at <100 μg/ml
Target
bEnd.3
Assay
Not reported by source
Source publication
AnticancerCytotoxicPositive observation
Record detail

OMV^MPI-SP and OMV^MPI-C treatments resulted in better therapeutic outcomes with statistical significance when compared with the PBS group.

Mention PMC10043419::PEP000004PMC10043419figure
Measure
survival_rate
Value
better therapeutic outcomes
Target
Mus musculus
Assay
Not reported by source
Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.