PepDiana
Back to Evidence
Paper-scoped peptide mentionSequence not reported or unresolved

MPI-N

PMC10043419::PEP000003

Source publication

Bioengineered bacterial outer membrane vesicles encapsulated Polybia–mastoparan I fusion peptide as a promising nanoplatform for bladder cancer immune-modulatory chemotherapy

Frontiers in Immunology · 2023

DOI 10.3389/fimmu.2023.1129771PMC10043419PMID 36999028
Sequence status
not reported or unresolved
Standardization
Sequence unresolved
Source location
unknown
Activity records
5

Sequence evidence

Reported molecular identity

The publication reports a peptide label or compound identity, but no sequence could be safely standardized from the available text, table, figure, or structure context.

Fusion protein with MPI at the N terminal (MPI-N). The codon-optimized DNA sequence encoding MPI ... was synthesized ... and then cloned into a commercial plasmid vector pET43.1a.

Experimental observations

Records linked to this mention

AnticancerCytotoxicPositive observation
Record detail

Both of them had a pronounced reduction of their viabilities when treated with bioengineered OMVs (OMV^MPI-N, OMV^MPI-SP, and OMV^MPI-C) for 24 h when compared with OMV^WT treatment.

Mention PMC10043419::PEP000003PMC10043419figure
Measure
cell_viability
Value
reduced viability
Target
MB49
Assay
Not reported by source
Source publication
AnticancerCytotoxicPositive observation
Record detail

Both of them had a pronounced reduction of their viabilities when treated with bioengineered OMVs (OMV^MPI-N, OMV^MPI-SP, and OMV^MPI-C) for 24 h when compared with OMV^WT treatment.

Mention PMC10043419::PEP000003PMC10043419figure
Measure
cell_viability
Value
reduced viability
Target
UMUC3
Assay
Not reported by source
Source publication
AnticancerCytotoxicNegative / threshold
Record detail

However, a non-carcinomatous cell named bEnd.3 ... exhibited no viability suppression when being treated with different OMVs at the concentration of <100 μg/ml (Figure S5).

Mention PMC10043419::PEP000003PMC10043419supplement
Measure
cell_viability
Value
no viability suppression at <100 μg/ml
Target
bEnd.3
Assay
Not reported by source
Source publication
AnticancerCytotoxicPositive observation
Record detail

Although OMV^WT and OMV^MPI-N presented slight inhibition potency, OMV^MPI-SP and OMV^MPI-C treatments resulted in better therapeutic outcomes with statistical significance when compared with the PBS group.

Mention PMC10043419::PEP000003PMC10043419figure
Measure
survival_rate
Value
slight inhibition potency
Target
Mus musculus
Assay
Not reported by source
Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.