Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 789
Aptamer sequence: GGCGGUGCUGGCCGAAAGGCGCUUGGAAACGUC
Target unique ID: 2153
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_713 sequence 2 (S2) Molecule Theophylline 0.391 μM 100 mM HEPES, 50 mM NaCl, and 10 mM MgCl2 26642994
Structure information of aptamer
Aptamer Sequence: GGCGGUGCUGGCCGAAAGGCGCUUGGAAACGUC
The optimal secondary structure in dot-bracket notation: ((((...((((((....)))...)))...))))
The centroid secondary structure in dot-bracket notation: ((((......(((....))).........))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_713 Description sequence 2 (S2)
Aptamer chemistry RNA Length 33 nt
GC content 66.7% Molecular weight 10,718.43 Da
Molarity of 1 μg/μl solution 93.30 μM Number of G-quadruplexes 2
G-Score 19 Function Targeted binding
Sequence GGCGGUGCUGGCCGAAAGGCGCUUGGAAACGUC
Applications Binding to theophylline
Target information
Type Detail Type Detail
PubChem ID 2153 Molecular name Theophylline
Molecular formula C7H8N4O2 Molecular weight 180.16
IUPAC name 1,3-dimethyl-7H-purine-2,6-dione InChIKey ZFXYFBGIUFBOJW-UHFFFAOYSA-N
LogP -1.04 Topological polar surface area 72.68
Hydrogen bond acceptor 5 Hydrogen bond donor 1

Synonym(s):
theophylline; 58-55-9; 1,3-Dimethylxanthine; Elixophyllin; Theophyllin; Theolair; Nuelin; Theophylline anhydrous; Respbid; Theocin; Theo-dur; Elixophylline; Pseudotheophylline; Lanophyllin; Theovent; Uniphyl; Slo-phyllin; Accurbron; Armophylline; Bronkodyl; Doraphyllin; Liquophylline; Maphylline; Medaphyllin; Optiphyllin; Parkophyllin; Synophylate; Teofyllamin; Theacitin; Theocontin; Uniphyllin; Xantivent; Aerolate; Elixicon; Solosin; Teolair; Theobid; Theofol; Theograd; Theolix; Elixex; Acet-theocin; Slo-bid; Theophyl-225; Aerolate III; Duraphyl; Euphylong; Sustaire; Xanthium; Austyn; Somophyllin-t; Constant-T; Teofilina; Theochron; Asmax; Quibron T/SR; Theal tablets; 1,3-dimethyl-7H-purine-2,6-dione; Somophyllin-DF; Bronkodyl SR; Theoclair-SR; Theoclear LA; Spophyllin retard; Choledyl SA; Quibron-T; Theoclear 80; Theophyline; Theo-11; Theo-24; Theostat 80; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione; Synophylate-L.A. Cenules; Theophylline, anhydrous; Theo-Dur-Sprinkle; Aquaphyllin; Tefamin; Theodel; Unifyl; Theona P; 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione; LaBID; Euphylline; Elixomin; Theolixir; Theophyl; Bronkotabs; Elixophyllin SR; Theophylline-SR; Somophyllin-CRT; Aerolate SR; Theo-Organidin; Theolair-SR; Theophyl-SR; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-; GS 2591A; Uni-Dur; Theoclear-80; Quibron-T/SR; T-Phyl; Theoclear-200; Xanthine, 1,3-dimethyl-; Dimethylxanthine; NSC 2066; X 115; Quadrinal; Theobid Jr.; Theoclear L.A.-130; Theal tabl.; 1,3-dimethyl-1H-purine-2,6(3H,7H)-dione; 1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; UNII-0I55128JYK; 2,6-Dihydroxy-1,3-dimethylpurine; Purine-2,6(1H,3H)-dione, 1,3-dimethyl-; Aerobin; Theodur; Theopek; Theospan; CHEMBL190; Theophylline [USP]; 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-; MLS000069390; 1,3-Dimethylxanthine;Theo-24; Diffumal; 1,3-dimethyl-1H-purine-2,6(3H,9H)-dione; CHEBI:28177; LASMA; 0I55128JYK; Pro-vent; Theophylline melting point standard; NSC-2066; 58-55-9 (ANHYDROUS); MFCD00079619; Teofilina [Polish]; NCGC00018117-07; NCGC00018117-17; Mudrane; Pulmidur; SMR000058537; Teonova; Theokin; Hylate; DSSTox_CID_1336; Nuelin SA; Bronchodid Duracap; DSSTox_RID_76090; Uniphyllin continus; DSSTox_GSID_21336; Teocen 200; Elixophyllin(e); CAS-58-55-9; Theolair (TN); Elixophyllin (TN); Uniphyl (TN); Quibron-t (TN); Theodur G (TN); CCRIS 4729; HSDB 3399; 1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione; SR-01000075195; EINECS 200-385-7; Theo-24 (TN); Telbans; Physpa; AI3-50216; Unicontin CR; 4eoh; Aescin-IIA; 1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine; Theophylline form II; theophylline solu-tion; component of Primatene; Xanthine,3-dimethyl-; Opera_ID_76; Spectrum_001038; Theophylline (JP17); 2a3a; Prestwick0_000820; Prestwick0_000873; Prestwick1_000820; Prestwick1_000873; Prestwick2_000820; Prestwick2_000873; Prestwick3_000820; Prestwick3_000873; Spectrum2_000842; Spectrum3_000672; Spectrum4_000353; Spectrum5_001232; 8-(2-Furyl)theophylline; UPCMLD-DP123; component of Theo-Organidin; EC 200-385-7; SCHEMBL4915; Theophylline Anhydrous,(S); 1,3-dimethyl-1,3,7-trihydropurine-2,6-dione; Theophylline Anhydrous, USP; Lopac0_000014; BSPBio_000719; BSPBio_000945; BSPBio_002363; component of Dicurin Procaine; GTPL413; KBioGR_000785; KBioSS_001518; MLS002152943; MLS002153487; MLS004491910; MLS006011970; BIDD:ER0557; BIDD:GT0151; DivK1c_000203; SPECTRUM1500568; SPBio_000823; SPBio_002640; SPBio_002866; BPBio1_000791; BPBio1_001041; SCHEMBL8312163; component of Tedral (Salt/Mix); DTXSID5021336; UPCMLD-DP123:001; BCBcMAP01_000071; BDBM10847; BDBM82053; component of Quibron (Salt/Mix); HMS500K05; KBio1_000203; KBio2_001518; KBio2_004086; KBio2_006654; KBio3_001583; NSC2066; component of Hecadrol (Salt/Mix); NINDS_000203; HMS1921E03; HMS2089A06; HMS2092M05; HMS2233E16; HMS3259O06; HMS3369N14; Pharmakon1600-01500568; component of Primatene (Salt/Mix); BCP30664; component of Bronkotabs (Salt/Mix); HY-B0809; STR01537; Theophylline 1.0 mg/ml in Methanol; Theophylline, >=99.0% (HPLC); Theophylline-[1,3-15N2,13C]; Tox21_110827; Tox21_202375; Tox21_300028; BBL023514; CCG-20301; NSC757346; PDSP1_001018; PDSP1_001234; PDSP2_001002; PDSP2_001218; STK397040; Theophylline (1,3-dimethylxanthine); ZINC18043251; AKOS000120961; AKOS005434016; component of Quibron Plus (Salt/Mix); Tox21_110827_1; component of Quibron-T/SR (Salt/Mix); component of Theo-organdin (Salt/Mix); component of Theolair plus (Salt/Mix); CS-4158; DB00277; MCULE-8236489917; NC00542; NSC-757346; Purine-2,3H)-dione, 1,3-dimethyl-; SDCCGMLS-0066620.P001; SDCCGSBI-0050003.P005; component of Theo-Organidin (Salt/Mix); IDI1_000203; SMP1_000291; component of Slo-phyllin GG (Salt/Mix); NCGC00018117-01; NCGC00018117-02; NCGC00018117-03; NCGC00018117-04; NCGC00018117-05; NCGC00018117-06; NCGC00018117-08; NCGC00018117-09; NCGC00018117-10; NCGC00018117-11; NCGC00018117-12; NCGC00018117-13; NCGC00018117-14; NCGC00018117-15; NCGC00018117-16; NCGC00018117-18; NCGC00018117-19; NCGC00018117-20; NCGC00018117-23; NCGC00018117-37; NCGC00022112-03; NCGC00022112-04; NCGC00022112-05; NCGC00022112-07; NCGC00022112-08; NCGC00022112-09; NCGC00022112-10; NCGC00022112-11; NCGC00022112-12; NCGC00254040-01; NCGC00259924-01; WLN: T56 BM DN FNVNVJ F1 H1; AC-20328; component of Dicurin Procaine (Salt/Mix); NCI60_001736; SMR003435989; Theophylline, anhydrous, >=99%, powder; component of Primatene tablets (Salt/Mix); Purine,6(1H,3H)-dione, 1,3-dimethyl-; SBI-0050003.P004; component of Mudrane GG elixir (Salt/Mix); DB-053224; Theophylline 100 microg/mL in Acetonitrile; 1H-Purine-2, 3,7-dihydro-1,3-dimethyl-; AB00052106; FT-0631259; FT-0675140; N1442; T0179; 6461-EP1441224A2; 6461-EP2272835A1; 6461-EP2272841A1; 6461-EP2272844A1; 6461-EP2280006A1; 6461-EP2281813A1; 6461-EP2281815A1; 6461-EP2286811A1; 6461-EP2295434A2; 6461-EP2298305A1; 6461-EP2301933A1; 6461-EP2301936A1; 6461-EP2301937A1; 6461-EP2305219A1; 6461-EP2305640A2; 6461-EP2308562A2; 6461-EP2311827A1; 6461-EP2314590A1; C07130; D00371; D85002; 83377-EP2371823A1; AB00052106-20; AB00052106-22; AB00052106-23; AB00052106_24; AB00052106_25; AB00052106_26; A900445; L000595; Q407308; 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione #; Q-201819; SR-01000075195-1; SR-01000075195-3; SR-01000075195-5; 1,3-Dimethyl-6-hydroxy-1,3-dihydro-2H-purin-2-one; BRD-K97799481-001-02-0; BRD-K97799481-001-12-9; BRD-K97799481-002-03-6; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, mo; F2173-0145; Z271004650; A3133D49-AAB6-49A1-B60B-B5198F327D3F; Theophylline, British Pharmacopoeia (BP) Reference Standard; Theophylline, European Pharmacopoeia (EP) Reference Standard; (8alpha, 9S)-10,11-Dihydro-6'-methoxycinchonan-9-amine trihydrochloride, min. 90%; Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard; Theophylline solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material; 1246816-25-0; 50857-74-4; 75448-53-2; Theo-24;1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione ;1,3-Dimethylxanthine;1,3-dimethyl-xanthin; Theophylline melting point standard, Pharmaceutical Secondary Standard; Certified Reference Material; Theophylline, certified reference material, United States Pharmacopeia (USP) Reference Standard

Activity data

No relevant experimental diagram

 Interaction ID 789
Target type Molecule
Target unique ID 2153
Activity 0.391 μM
Binding Conditions/Buffer

100 mM HEPES, 50 mM NaCl, and 10 mM MgCl2
Assay

N/A
PubMed ID 26642994
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_712 RNA GGCGGUGCUCGCCGAAAGGCUCCUGGAUACGUC
87.88%
Apta_714 RNA GGCGGUUCCUGCCGAAAGGCUCGUGGCAACGUC
81.82%
Apta_715 RNA GGCGCUGCACGCCGAAAGGCCCGUUGAAACGUC
81.82%
Apta_711 RNA GGCGAUACCAGCCGAAAGGCCCUUGGCAGCGUC 78.79%
Apta_717 RNA GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC 78.79%
Apta_716 RNA GGCGCUUCAUGCCGAAAGGCCCGUUGUAACGUC 75.76%
Apta_138 RNA GGAGGUGCUCCGAAAGGAACUCC 60.61%
Apta_370 RNA GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG 55.26%
Apta_560 RNA GGAAGAGAUGGCGACUAAAACGACUUGUCGC 54.55%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 52.63%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 52.63%
Apta_703 RNA GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG 52.38%
Apta_1140 RNA UAGUGUGAGAGCCGUGAGUGAAAGGCCGCGACAAAGAUCGGA 52.38%
Apta_632 RNA GACGAGAAGGAGUGCUGGUUAUACUAGCGGUUAGGUCACUCGUC 52.27%
Apta_21 DNA TGTGGGGGAGGACGGGCGGGGATGC 51.52%
Apta_243 RNA GCUUGAAGCUAGCAGUAAGACUAGCGCUACGGAUGGGUGUGCG 51.16%
Apta_98 RNA CGAUGCGGUCUCAUGCGUCGAGUGUGAGUUUACCUUCG 50.00%
Apta_394 RNA GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC 50.00%
Apta_402 RNA GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC 50.00%
Apta_521 RNA GGGUUGGGAAGAAACUGUGGCACUUCGGUGCCAGCAACCC 50.00%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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