Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_245 | ILPR2 | Protein | IGF1R_HUMAN | 10 μM | 20 mM Tris, 5mM KCl, pH 7.3 | 16608332 |
Structure information of aptamer
| Aptamer Sequence: | ACAGGGGTGTGGGGACAGGGGTGTGGGG |
| The optimal secondary structure in dot-bracket notation: | (((....(((....)))....))).... |
| The centroid secondary structure in dot-bracket notation: | (((....(((....)))....))).... |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_245 | Description | ILPR2 |
| Aptamer chemistry | DNA | Length | 28 nt |
| GC content | 71.4% | Molecular weight | 9,151.65 Da |
| Molarity of 1 μg/μl solution | 109.27 μM | Number of G-quadruplexes | 4 |
| G-Score | 84 | Function | Target detection |
| Sequence | ACAGGGGTGTGGGGACAGGGGTGTGGGG | ||
| Applications | In vivo detection and sensing of insulin as well as its isolation and purification from biological samples | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P08069 | Protein name | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] |
| Gene name(s) | IGF1R | Organism | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] |
| Status | reviewed in uniprot database | Length | 1367 |
| Mass | 154,793 | Activity regulation | Activated by autophosphorylation at Tyr-1165, Tyr-1161 and Tyr-1166 on the kinase activation loop |
| Involvement in disease | Insulin-like growth factor 1 resistance (IGF1RES) | Catalytic activity | Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] |
| PDB ID(s) | 1IGR;1JQH;1K3A;1M7N;1P4O;2OJ9;2ZM3;3D94;3F5P;3I81;3LVP;3LW0;3NW5;3NW6;3NW7;3O23;3QQU;4D2R;4XSS;5FXQ;5FXR;5FXS;5HZN;5U8Q;5U8R;6JK8;6VWG;6VWH;6VWI;6VWJ; |
 |
Function | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). |
Activity data
|
No relevant experimental diagram |
Interaction ID | 250 |
| Target type | Protein | |
| Target unique ID | P08069 | |
| Activity | 10 μM | |
| Binding Conditions/Buffer | 20 mM Tris, 5mM KCl, pH 7.3 |
|
| Assay | N/A |
|
| PubMed ID | 16608332 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_13 | DNA | AGGGGGGGGGGAGGGGTCGGGGTGG | |
| Apta_11 | DNA | AGAGGGGGGGGTCGGGGTGGGTCGC | |
| Apta_12 | DNA | TGAGGGGGTGGGTGGGACGGGTTGG | |
| Apta_14 | DNA | AGCGGGGGGGGCTGGGCTGGGTGGG | |
| Apta_1262 | DNA | ACAAGGGGTGCAGGGGTCCGCGATTGTGACTGTGTGTGCG | |
| Apta_10 | DNA | GGGGGGGGTGGCTGGGCGGGGTGGG | |
| Apta_26 | DNA | AGGGGGGGGGGTAAGGGTGGGTAGA | |
| Apta_30 | DNA | AGAGGGGGGGGTGGAGGGGGCTAGA | |
| Apta_1195 | DNA | GGGGTTGGGGGGAGGCGGGGAATGGGGG | |
| Apta_746 | DNA | AGAGTGGGGGGGTGGGTGGATTTGACAGGTGGCATGCTGGAGAGT | |
| Apta_46 | DNA | CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT | |
| Apta_869 | DNA | ACTAGGACGCTTGGGAGGGGGGGTGGGGTGTCCGGTCGCG | |
| Apta_15 | DNA | TGAGGGGGGGGGAGGGCGGGGCTGC | |
| Apta_16 | DNA | AGGGGGGGGGGACGGGACGGGTATA | |
| Apta_17 | DNA | AGGGGGGGGGGTGGGGGTGGGTCCC | |
| Apta_20 | DNA | AGAGGGGGGGGTGGGGGTGGCCTGC | |
| Apta_29 | DNA | AGAGGGGGGGGACGGCCCGGGTAGA | |
| Apta_350 | DNA | GGTGGTGGTGGTTGTGGTGGTGGTGG | |
| Apta_389 | DNA | GCCTGTGGTGTTGGGGCGGGTGCG | |
| Apta_390 | DNA | GGTGCGGCGGGACTAGTGGGTGTG |
DEV TOOL
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