Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1094 | aptamer | Molecule | Perfluorooctanoic acid | 5.5 μM | 20 mM HEPES, 1 M NaCl, 10 mM MgCl2, and 5 mM KCl | 34991260 |
Structure information of aptamer
| Aptamer Sequence: | GGAATCGTGGGTGGTAGGGTAGGGGATGCA |
| The optimal secondary structure in dot-bracket notation: | ...(((.((.....)).))).......... |
| The centroid secondary structure in dot-bracket notation: | .....(.(.......).)............ |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1094 | Description | aptamer |
| Aptamer chemistry | DNA | Length | 30 nt |
| GC content | 60.0% | Molecular weight | 9,488.09 Da |
| Molarity of 1 μg/μl solution | 105.40 μM | Number of G-quadruplexes | 2 |
| G-Score | 20 | Function | Aptasensor |
| Sequence | GGAATCGTGGGTGGTAGGGTAGGGGATGCA | ||
| Applications | Fluorescence sensor for perfluorooctanoic acid、perfluoroheptanoic acid、perfluorohexanesulfonic acid detection in water | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 9554 | Molecular name | Perfluorooctanoic acid |
| Molecular formula | C8HF15O2 | Molecular weight | 414.07 |
| IUPAC name | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoic acid | InChIKey | SNGREZUHAYWORS-UHFFFAOYSA-N |
| LogP | 4.445 | Topological polar surface area | 37.3 |
| Hydrogen bond acceptor | 1 | Hydrogen bond donor | 1 |
Synonym(s): PERFLUOROOCTANOIC ACID; Pentadecafluorooctanoic acid; 335-67-1; PFOA; Perfluorocaprylic acid; 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoic acid; Octanoic acid, pentadecafluoro-; Perfluoroctanoic acid; Perfluoroheptanecarboxylic acid; Pentadecafluoro-1-octanoic acid; Pentadecafluoro-n-octanoic acid; Perfluoro-n-octanoic acid; IPC-PFFA-8 HG; NSC 95114; UNII-947VD76D3L; n-perfluorooctanoic acid; DTXSID8031865; CHEBI:35549; Hexanoyl fluoride, 3,3,4,4,5,5,6,6,6-nonafluoro-2-oxo-; 947VD76D3L; MFCD00004174; Octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-; CCRIS 4386; HSDB 7137; EINECS 206-397-9; IPC-PFFA-8; BRN 1809678; AI3-19341; C8HF15O2; 8PF; 960315-48-4; ammonium-perfluorocaprylate; C7F15COOH; perfluorooctylcarboxylic acid; DSSTox_CID_11865; DSSTox_RID_78895; DSSTox_GSID_31865; SCHEMBL22556; Perfluorooctanoic acid, 96%; SILVERPERFLUOROOCTANOATE; Fluorad FC-26 (Salt/Mix); CHEMBL172988; Perfluorooctanoic Acid High Grade; CS-B0915; NSC95114; ZINC6844606; Pentadecafluorooctanoic acid solution; Tox21_300688; NSC-95114; Pentadecafluorooctanoic Acid-[13C4]; AKOS005259894; FD10557; LS40741; MCULE-1103416295; Pentadecafluorooctanoic Acid High Grade; NCGC00164448-01; NCGC00164448-02; NCGC00164448-03; NCGC00254596-01; AS-15245; CAS-335-67-1; O617; SY049851; DB-048447; FT-0631976; FT-0673629; P0764; Pentadecafluorooctanoic acid, analytical grade; Pentadecafluorooctanoic acid, analytical standard; A821847; Q418348; W-106771; Perfluorooctanoic acid 100 microg/mL in Acetonitrile; Perfluorooctanoic acid 50 microg/mL in Methanol:Water; Z1270326259; Hexanoyl fluoride,3,4,4,5,5,6,6,6-nonafluoro-2-oxo-; 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-Octanoic Acid; 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoic acid #; Pentadecafluorooctanoic acid solution, 100 mug/mL in methanol, analytical standard
Activity data
|
No relevant experimental diagram |
Interaction ID | 1148 |
| Target type | Molecule | |
| Target unique ID | 9554 | |
| Activity | 5.5 μM | |
| Binding Conditions/Buffer | 20 mM HEPES, 1 M NaCl, 10 mM MgCl2, and 5 mM KCl |
|
| Assay | N/A |
|
| PubMed ID | 34991260 | |
|
No relevant experimental diagram |
Interaction ID | 1149 |
| Target type | Molecule | |
| Target unique ID | 67818 | |
| Activity | 6.5 μM | |
| Binding Conditions/Buffer | 20 mM HEPES, 1 M NaCl, 10 mM MgCl2, and 5 mM KCl |
|
| Assay | N/A |
|
| PubMed ID | 34991260 | |
|
No relevant experimental diagram |
Interaction ID | 1150 |
| Target type | Molecule | |
| Target unique ID | 67734 | |
| Activity | 3.3 μM | |
| Binding Conditions/Buffer | 20 mM HEPES, 1 M NaCl, 10 mM MgCl2, and 5 mM KCl |
|
| Assay | N/A |
|
| PubMed ID | 34991260 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_25 | DNA | TGTGGGGGTGGTTGGGCGGGGCTGC | |
| Apta_74 | DNA | GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC | |
| Apta_15 | DNA | TGAGGGGGGGGGAGGGCGGGGCTGC | |
| Apta_21 | DNA | TGTGGGGGAGGACGGGCGGGGATGC | |
| Apta_350 | DNA | GGTGGTGGTGGTTGTGGTGGTGGTGG | |
| Apta_669 | DNA | AACGTGGGAGGGCGGTGGTGTTGAA | |
| Apta_71 | DNA | GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC | |
| Apta_72 | DNA | AGTCAGTAGGTTGGTGTGGTTGGGGCTGACT | |
| Apta_1256 | DNA | GATCGGGTGTGGGTGGCGTAAAGGGAGCATCGGACA | |
| Apta_8 | DNA | TGTGGGGGTGGACGGGCCGGGTAGA | |
| Apta_10 | DNA | GGGGGGGGTGGCTGGGCGGGGTGGG | |
| Apta_12 | DNA | TGAGGGGGTGGGTGGGACGGGTTGG | |
| Apta_19 | DNA | TGAGGGGGGGGGAGGTCGGGCCTGC | |
| Apta_20 | DNA | AGAGGGGGGGGTGGGGGTGGCCTGC | |
| Apta_26 | DNA | AGGGGGGGGGGTAAGGGTGGGTAGA | |
| Apta_30 | DNA | AGAGGGGGGGGTGGAGGGGGCTAGA | |
| Apta_63 | DNA | GACCCGTGGTAGGGTAGGATGGGGTGGTC | |
| Apta_66 | DNA | TACCGTGGTAGGGAAGGTTGGAGTGTA | |
| Apta_389 | DNA | GCCTGTGGTGTTGGGGCGGGTGCG | |
| Apta_757 | DNA | GGTGGTGGTGGTTGTGGTGGTGG |
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